Recent contributions for a better understanding of the Trypanosoma cruzi - muscle cell interaction

Meirelles, Maria de Nazareth Leal de; Barbosa, Helene Santos; Souza, Wanderley de; Jorge, Tania C. de Araujo

doi:10.1590/s0074-02761984000500004

Mem. Inst. Oswaldo Cruz

1984

DOI: 10.1590/s0074-02761984000500004

|View full text |Cite

Recent contributions for a better understanding of the Trypanosoma cruzi - muscle cell interaction

Maria de Nazareth Leal de Meirelles¹,

Helene Santos Barbosa²,

Wanderley de Souza

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1986

2013

Publication Types

Select...

Article6

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 8 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Host cell and parasites -Hearts of 18 days old mouse embryos of Swiss mice were submitted to mechanical and to enzymatic dissociation using trypsin 0.05% and 0.01% collagenase in phosphate buffer saline (PBS) at 37°C, following the method previously described (Meirelles et al 1984(Meirelles et al , 1986.…”

mentioning

confidence: 99%

Characterization of [Ca2+]i responses in primary cultures of mouse cardiomyocytes induced by Trypanosoma cruzi trypomastigotes

Garzoni

Masuda

Capella³

et al. 2003

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

mentioning

confidence: 99%

Characterization of [Ca2+]i responses in primary cultures of mouse cardiomyocytes induced by Trypanosoma cruzi trypomastigotes

Garzoni

Masuda

Capella³

et al. 2003

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

The interaction of myotropic and macrophagotropic strains ofTrypanosoma cruzi with myoblasts and fibers of skeletal muscle

et al. 1986

View full text Add to dashboard Cite

The process of interaction of bloodstream trypomastigotes from the myotropic CL and Colombiana strains and the macrophagotropic Y strain of Trypanosoma cruzi with mouse myoblasts and myotubes was analysed. After 24 h of parasite-host cell interaction, parasites from the CL and Colombiana strains appeared to be more infective to myoblasts than those from the Y strain. Parasites from the Colombiana strain were more infective for myotubes than those from the Y strain, while those from the CL strain showed very a low ability to infect the cells. For all strains the infectivity was low for short periods of interaction, increasing with time. Myoblasts infected with parasites from the Y strain fused with other infected and uninfected cells to form myotubes. However, the process of fusion was blocked when the myoblasts were infected with parasites from the CL and Colombiana strains. These data indicate a different behavior of muscle cells when in contact with myotropic or non-myotropic strains of T. cruzi.

show abstract

Trypanosoma cruzi: Inhibition of host cell uptake of infective bloodstream forms by alpha-2-macroglobulin

1986

Z. Parasitenkd.

View full text Add to dashboard Cite

The infection of murine macrophages and fibroblasts by recently isolated infective bloodstream trypomastigotes of Trypanosoma cruzi is inhibited by the addition of human plasma protease inhibitor alpha-2-macroglobulin (alpha 2M) or of soybean trypsin inhibitor. The ingestion of the non-infective epimastigotes by macrophages is not affected by the physiological protease inhibitor. Incubation of bloodstream trypomastigotes for 20 h in a serum-free axenic medium enhances their ability to infect macrophages in a process influenced by the temperature and sensitive to alpha 2M. After this period the infectivity of the parasites to cells was not sensitive to alpha 2M. These observations suggest that proteases located on the surface and/or secreted by the bloodstream trypomastigote form of T. cruzi may modulate its ability to infect host cells.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Recent contributions for a better understanding of the Trypanosoma cruzi - muscle cell interaction

Cited by 8 publications

References 0 publications

Characterization of [Ca2+]i responses in primary cultures of mouse cardiomyocytes induced by Trypanosoma cruzi trypomastigotes

Characterization of [Ca2+]i responses in primary cultures of mouse cardiomyocytes induced by Trypanosoma cruzi trypomastigotes

The interaction of myotropic and macrophagotropic strains ofTrypanosoma cruzi with myoblasts and fibers of skeletal muscle

Trypanosoma cruzi: Inhibition of host cell uptake of infective bloodstream forms by alpha-2-macroglobulin

Contact Info

Product

Resources

About