Calomys callosus Rengger, 1830 (Rodentia-Cricetidae): sua caracterização, distribuição, biologia, criação e manejo de uma cepa em laboratório

Mello, Darli A. A.

doi:10.1590/s0074-02761984000100003

Cited by 7 publications

(3 citation statements)

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“…This animal is widely distributed throughout South America, and it is found from northern Argentina to eastern Andes, and in Bolivian and Paraguayan Chaco. In Brazil, it may be found in the middle west, north‐east and in the southern regions up to the Paraná State (Mello, 1984). The savannah environment in the middle eastern part of Brazil is one of its main natural habitats.…”

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confidence: 99%

Histological and serological evidence of experimental paracoccidioidomycosis in Calomys callosus (Rodentia: Cricetidae)

Berbert

Faria

Gennari-Cardoso

et al. 2006

Int J Experimental Path

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The responses of animal experimental models related to the infectivity, virulence and pathogenicity of Paracoccidioides brasiliensis is constantly used to develop new perspectives of investigation. The rodent Calomys callosus, Rengger 1830 (Rodentia: Cricetidae) is an indigenous inhabitant of the savannah environment found in the central regions of Brazil. The aim of the present work was to evaluate the histopathological and serological features of C. callosus after inoculation with the Pb18 strain of P. brasiliensis. Furthermore, A/Sn and B10.A mice strains were also tested to compare the results obtained in C. callosus to these well-established experimental models of resistance and susceptibility respectively. In every instance, survival analysis was performed, and histopathological study of the lungs, liver and spleen was employed to investigate tissue involvement, degree of inflammation and fungal presence. Levels of antibodies to P. brasiliensis were measured by using an enzyme-linked immunosorbent assay after 4 weeks and at the advanced stage of infection. The mortality rate was proportional to inoculation dose in all groups, but overall it was much superior in C. callosus than in the B10.A-susceptible mice. Macroscopical and microscopical pathological alterations were also more extensive and remarkable for C. callosus, once again proportional to inoculation dose, but more noticeable differences among the studied groups were found with 0.6x10(5) inoculum. In addition, the serological profile of C. callosus was similar to that found for B10.A-susceptible mice. Infection of C. callosus with 0.6x10(8) Pb18 inoculum resulted in more serious illness, and it decreased in severity in proportion to the inoculum dose. This difference was more pronounced in C. callosus, and the clinical, serological and pathological findings in this animal were more intense and precocious compared with the B10.A-susceptible mice. The present results suggest that C. callosus is a potentially alternative experimental animal model for paracoccidioidomycosis infection.

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confidence: 99%

Histological and serological evidence of experimental paracoccidioidomycosis in Calomys callosus (Rodentia: Cricetidae)

Berbert

Faria

Gennari-Cardoso

et al. 2006

Int J Experimental Path

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“…The colony of C. callosus was raised and handled as described elsewhere (Mello 1984). C. callosus and X. cheopis were from colonies maintained at the Plague Laboratory of the CPqAM.…”

Section: Animalsmentioning

confidence: 99%

Transmission of Yersinia pestis cultures with different plasmid content from Xenopsylla cheopis to Calomys callosus

et al. 2003

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Most Brazilian Yersinia pestis isolates display a typical plasmid profile composed of the three classical plasmids: pYV, pPst and pFra. However, some cultures lack at least one of these plasmids, while a few of them harbour atypical DNA bands of molecular weight ranging from 147 to 11.5 kb. To investigate whether Y. pestis displaying atypical plasmid content could be propagated among rodents in nature through flea bites, we carried out studies with fleas (Xenopsylla cheopis) and rodents (Calomys callosus) reared in the laboratory and five Y. pestis cultures differing in plasmid content. The results suggest that: (1) the single presence of pYV is not sufficient for the transmission of Y. pestis by fleas, (2) pPst is not essential for transmission, (3) two atypical DNA bands of molecular weight of 30 kb and >90 kb have no biological role, and (4) pFra is required for the transmission of Y. pestis by flea bites. Other studies are needed to determine whether this plasmid alone is sufficient for transmission.

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“…The introduction of C. callosus as a laboratory animal occurred in 1967 by Petter et al [ 5 ]. Since they were bred for this purpose, these rodents have characteristics such as easy handling, satisfactory longevity, and reproducibility [ 6 , 7 , 8 ]. Currently the biology, behavior, and anatomy of C. callosus are well known, as the species has been established in experimental laboratories and is considered an effective model to be used in infectious disease studies [ 5 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Calomys callosus: An Experimental Animal Model Applied to Parasitic Diseases Investigations of Public Health Concern

et al. 2022

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The appearance and spread of parasitic diseases around the world aroused the interest of the scientific community to discover new animal models for improving the quality and specificity of surveys. Calomys callosus is a rodent native to South America, an easy handling model, with satisfactory longevity and reproducibility. C. callosus is susceptible to toxoplasmosis and can be used as experimental model for the study the pathogenesis, treatment, vertical transmission, and ocular toxoplasmosis. C. callosus can also be used to study cutaneous and visceral leishmaniasis, as the animals present cutaneous lesions, as well as parasites in the organs. C. callosus has epidemiological importance in Chagas disease, and since it is a Trypanosoma cruzi natural host in which rodents show high parasitemia and lethality, they are also effective as a model of congenital transmission. In the study of schistosomiasis, Schistosoma mansoni was proven to be a C. callosus natural host; thus, this rodent is a great model for fibrosis, hepatic granulomatous reaction, and celloma associated with lymphomyeloid tissue (CALT) during S. mansoni infection. In this review, we summarize the leading studies of parasitic diseases that used C. callosus as a rodent experimental model, describing the main uses and characteristics that led them to be considered an effective model.

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Calomys callosus Rengger, 1830 (Rodentia-Cricetidae): sua caracterização, distribuição, biologia, criação e manejo de uma cepa em laboratório

Cited by 7 publications

References 0 publications

Histological and serological evidence of experimental paracoccidioidomycosis in Calomys callosus (Rodentia: Cricetidae)

Histological and serological evidence of experimental paracoccidioidomycosis in Calomys callosus (Rodentia: Cricetidae)

Transmission of Yersinia pestis cultures with different plasmid content from Xenopsylla cheopis to Calomys callosus

Calomys callosus: An Experimental Animal Model Applied to Parasitic Diseases Investigations of Public Health Concern

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