Ensaios de vacinação preventiva e curativa nas infecções pelo Schizotrypanum cruzi

Muniz, Julio; Nobrega, G; Cunha, Marques da

doi:10.1590/s0074-02761946000300007

Cited by 13 publications

(2 citation statements)

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“…Based on this concept and considering the possible risks involved in immunization with live flagellates (1), several attempts have been made to prepare an effective immunogen with killed organisms. The use of parasites killed by either chemical (10,13,14) or some physical (11) means has usually yielded unsuccessful results, due perhaps to the aggresiveness of the reagents or procedures on the antigens. However, partial protection has been reported achieved with culture forms of T. cruzi killed by some physical methods (F. C. Goble, J. L. Boyd, M. G. Wehner, and M. Konrath, J. Parasitol.…”

Section: Resistance To Infection With Virulentmentioning

confidence: 99%

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Immunization Against Experimental Chagas' Disease by Using Culture Forms of Trypanosoma cruzi Killed with a Solution of Sodium Perchlorate

Kierszenbaum

Budzko

1975

Infect Immun

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Protection against infection with virulent blood (trypomastigote) forms of Trypanosoma cruzi was accomplished in mice by immunization with culture (mainly epimastigote) forms killed by treatment with sodium perchlorate. Sodium chloride, used instead of sodium perchlorate, with all other conditions kept the same, failed to kill all the organisms, indicating that the effects of the perchlorate anion were not simply ionic or osmotic, suggesting that they might be chaotropic. A single dose of the immunogen, without adjuvants, was sufficient to significantly protect against the infection. Protection was achieved by either intraperitoneal, intramuscular, or subcutaneous immunization, though the first two routes appeared to be more effective. After challenge, parasitemias were negative in 25, 29, and 17% of the animals immunized intraperitoneally, intramuscularly, and subcutaneously, respectively.

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Section: Resistance To Infection With Virulentmentioning

confidence: 99%

“…Mortality of mice infected with T. cruzi after immunization with TCSP by different routes. Symbols: (0) Control group (12) given PBS both intramuscularly and subcutaneously; (A) mice (14) immunized intramuscularly; (0) mice (12) immunized subcutaneously. The immunizing dose contained 25 mg (wet weight) of killed organisms.…”

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confidence: 99%