Semelhança entre os mecanismos de formação da anemia por soro anti-plaqueta e por benzoato de estradiol

Cruz, W. O.; Silva, E. M. da; Mello, R. Pimenta de

doi:10.1590/s0074-02761945000200005

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“…O financiamento de Guinle foi crucial para o deslanche da seção de hematologia (62), onde a partir da década de 1940, Walter O. Cruz se dedicou às pesquisas sobre regeneração do sangue, tendo como base de investigação os estudos da anemia na ancilostomose (21,(64)(65)(66). Uma ramificação destes estudos foram as "hemoglobinometrias", iniciadas com a viagem de 1938 e desenvolvidas nos anos 1940 apenas em populações urbanas (30,67,68).…”

Section: Relembrando O Episódio Em Que Oswaldo Cruzunclassified

Las investigaciones fisiológicas sobre la sangre y las interpretaciones de Brasil en la primera mitad del siglo xx

Cavalcanti¹

2015

Rev. Cienc. Salud

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Rev. Cienc. Salud. 13 (Especial): 47-64 / 47 Artículos de investigación en Estudios Sociales de la Salud As pesquisas fisiológicas sobre o sangue e as interpretações do Brasil na primeira metade do século xx Las investigaciones fisiológicas sobre la sangre y las interpretaciones de Brasil en la primera mitad del siglo xx Para citar este artigo: Manzoni Cavalcanti J. As pesquisas fisiológicas sobre o sangue e as interpretações do Brasil na primeira metade do século xx. Rev Cienc Salud 2015; 13 (esp): 47-64. Doi: dx.doi.org/10.12804/revsalud13.especial.2015.04 Resumo Objetivo: esclarece como as investigações sobre a fisiologia do sangue no Brasil contribuíram intensamente nas discussões sobre a formação histórica e cultural da sociedade brasileira. Desenvolvimento: Partindo da historiografia brasileira e do exame de trabalhos científicos desenvolvidos por Walter Oswaldo Cruz e na Seção de Hematologia do Instituto Oswaldo Cruz, analisam-se os conteúdos sociais dos enunciados científicos sobre o sangue em artigos sobre as causas das ditas anemias tropicais, a distribuição racial dos grupos sanguíneos e a quantificação da hemoglobina. Conclusões: Ao contrário da historiografia que limita a história da fisiologia a certos personagens, instituições e fatos, as histórias alternativas da fisiologia oferecem um cenário rico, no qual observamos a produção de conhecimentos sobre as funções orgânicas para além das ciências naturais. Palavras chave: história, saúde, sangue, fisiologia, Brasil. ResumenObjetivo: aclarar cómo las investigaciones sobre la fisiología de la sangre en Brasil contribuyeron intensamente en las discusiones sobre la formación histórica y cultural de la sociedad brasilera. Desarrollo: partiendo de la historiografía brasilera y del examen de trabajos científicos desarrollados por Walter Oswaldo Cruz y en la Sección de Hematología del Instituto Oswaldo Cruz, se analizan las caras sociales contenidas en los enunciados científicos sobre la sangre en artículos sobre las causas de dichas anemias tropicales, la distribución racial de los grupos sanguíneos y la cuantificación de la hemoglobina. Conclusiones: al contrario de la historiografía, que limita la historia de la fisiología a ciertos personajes, instituciones y hechos, las historias alternativas 1 História das Ciências e da Saúde da Casa de Oswaldo Cruz, Brasil. Correo electrónico: jujumanzoni@yahoo.com.br 48 / Rev. Cienc. Salud. 13 (Especial): 47-64Manzoni Cavalcanti J de la fisiología ofrecen un escenario rico, en el cual observamos la producción de conocimientos sobre las funciones orgánicas más allá de las ciencias naturales.Palabras clave: historia, salud, sangre, fisiología, Brasil. AbstractObjective: To analyze how research on blood physiology in Brazil informed the debates about historical and social development of the Brazilian society. Development: Throughout Brazilian historiography and the research of scientific works from Walter Oswaldo Cruz and the Hematology Department at the Instituto Oswaldo Cruz, this paper interprets the social content ...

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Section: Relembrando O Episódio Em Que Oswaldo Cruzunclassified

Las investigaciones fisiológicas sobre la sangre y las interpretaciones de Brasil en la primera mitad del siglo xx

Cavalcanti¹

2015

Rev. Cienc. Salud

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Contribution on the Thrombocytopenic Action of Urethane in Dogs*

Cruz

Silva

1949

British Journal of Pharmacology and Chemotherapy

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Thrombocytopenic purpura in dogs has been obtained by subcutaneous urethane administration (Cruz and Moussatch6, 1948). Suppurative reactions commonly occur in the skin ofthe experimental animals after a few injections. These reactions, possibly due to sensitization to the drug, are undesirable in experiments on the action ofurethane. The present paper deals with the results of urethane administration by vein, a route much more suitable for controlling the toxic doses. METHODSOur routine haematological technique has been described in a previous paper (Cruz, Silva, and Mello, 1945). We have estimated bleeding time according Duke's method (1910), coagulation time by Lee and White's method (1913), and clot-retraction by Macfarlane's method (1939). Urethane was used as a 60 per cent solution in distilled water. RESULTSWhen urethane is administered in high doses (0.4 g. or higher per kg. body weight) the animals usually eliminate faeces and urine immediately after the injections and show somnolentia followed by sound sleep for 10-15 minutes. This slight anaesthetic effect is of short duration, and animals become normal again after a drowsy period of about half an hour.No striking differences were observed between the action of urethane administered subcutaneously and intravenously so far as the time of the establishment of the purpuric picture or pathological findings are concerned.* Aided by a grant from Dr. Guilherme Guinle.The results of effective doses (0.4-0.5 g. per kg. body weight) administered to 5 dogs are shown in Table I. In 4 dogs platelets disappeared from the circulation between 6-9 days when bleeding time was already very much prolonged and the other signs of purpura were also present. The animals were sacrificed a few days later, and the haematological findings revealed a picture of severe anaemia. In one of these dogs platelets obtained by fractioned centrifugation of 50 c.c. of normal dog's blood were injected daily soon after the urethane administration in order to observe any eventual interference in the pathological picture. This preliminary experiment was completely negative. In another_dog (494-16) urethane was stopped after seven daily injections and blood changes were followed. Confirmation of other authors (Duke, 1911; Firket, 1922; and Tocantins, 1938) and our previous experiments concerning platelet regeneration have been verified. Normal platelet volume was attained 3-5 days after the beginning of the platelet regeneration, which only started 20 days after the absence of platelets in the peripheral blood. In one splenectomized dog (466-19) the evolution and the pathological picture were very similar to those of normal dogs treated with urethane (Table I).In order to ascertain the optimal doses to obtain the picture ofpurpura, higher and smaller doses than those described have been tried. As higher doses, we tried eight intravenous injections, each 0.4 g. per kg. body weight, within a period of 36 hours (dog 437-3) as well as two daily injections of a slightly higher dose (0.5 g. per kg...

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Acute Thrombocytopenia Induced in Dogs by Administration of Urethane (Ethylcarbamate)

Cruz

Moussatché

1948

Blood

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1. Dogs treated for one to two weeks with daily injections of urethane (ethyl carbamate) subcutaneously, in doses of 0.4 Gm. per Kg. of body weight, presented a typical picture of thrombocytopenic purpura. 2. The pathologic changes consisted in numerous purpuric lesions in the small intestine and a smaller number on the skin, heart, lung, cortical zone of the kidney, epiploon, and, rarely, on the stomach and large intestine. 3. The hematologic changes occurred in the following sequence: leukocytosis, leukopenia and thrombocytopenia, and finally acute anemia coinciding with severe intestinal hemorrhage. In the final phase, the coagulation time was normal and the bleeding time very much increased.

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Semelhança entre os mecanismos de formação da anemia por soro anti-plaqueta e por benzoato de estradiol

Cited by 3 publications

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Las investigaciones fisiológicas sobre la sangre y las interpretaciones de Brasil en la primera mitad del siglo xx

Las investigaciones fisiológicas sobre la sangre y las interpretaciones de Brasil en la primera mitad del siglo xx

Contribution on the Thrombocytopenic Action of Urethane in Dogs*

Acute Thrombocytopenia Induced in Dogs by Administration of Urethane (Ethylcarbamate)

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