A regulação do lobo anterior da hypophyse por um hormonio testicular, especialmente sob o ponto de vista morphologico

Martins, Thales; Rocha, Arnoldo

doi:10.1590/s0074-02761931000100005

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observations of Hohlweg and Dohrn (1931) show that progynon injections are curative in castrates of both sexes, but that it requires about 12 times the amount for male castrates as for females. Martins and Rocha (1931) in their studies on parabiotic twins showed that the injection of testis pulp or aqueous extracts of testis tissue into the castrated male in parabiotic union with a normal female prevented the development of precocious puberty in the normal female but that no such inhibition of the anterior lobe gonad-stimulating action was observed when the same extracts were injected into a castrated female parabiotically united with a normal female. They consider the substance to be sex specific and probably different in character from the accessory gland-stimulating substance.…”

Section: Action On the Anterior Hypophysismentioning

confidence: 99%

Biochemistry and assay of testis hormones.

Koch¹

1934

Sex and Internal Secretions: A Survey of Recent Research.

View full text Add to dashboard Cite

Section: Action On the Anterior Hypophysismentioning

confidence: 99%

Biochemistry and assay of testis hormones.

Koch¹

1934

Sex and Internal Secretions: A Survey of Recent Research.

View full text Add to dashboard Cite

Studies on the anterior hypophysis. III. The anterior hypophysis in vitamine E‐deficient rats

Nelson

1933

Anat. Rec.

View full text Add to dashboard Cite

The effects of castration upon the cytological picture of the rat hypophysis has been described by Addison ( '17). This author has shown that the basophiles enlarge markedly following gonadectomy, this enlargement finally attaining the so-called 'signet-ring' condition. Engle ( '29) and Evans and Simpson ( '29) consider this enlargement as indicating the storage of the gonad-stimulating hormone, because they were able to show that the hypophyses of gonadectomized rats are more potent than glands from normal animals in their capacity to stimulate the immature ovary. However, Emery's ('32) demonstration that the hormone occurs in the blood of castrated rats-a condition not present in normal animalsindicates that the gonad-stimulating factor is not confined to the hypophysis in castrated animals.These studies, as well as a number of others, especially those of Moore and Price ('32), are evidence for the existence of a reciprocal relationship between the gonads and the m t erior hypophysis. Thus the gonads are stimulated through the agency of the pituitary hormone, but the gonadal hormones exercise an inhibitory influence on the hypophysis. Removal of the pituitary causes gonadal regression, but gonadectomy permits abnormal pituitary activity.Inasmuch as gonadectomy in the male removes all of the testicular elements, it becomes of interest to inquire into the gonad-pituitary relations of animals in which only certain National Research Council Fellow 241

show abstract