Interaction between Paracoccidioides brasiliensis conidia and the coagulation system: involvement of fibrinogen

Tamayo, Diana; Hernández, Orville; Muñoz-Cadavid, Cesar; Cano, Luz Elena; González, Ángel

doi:10.1590/s0074-0276108042013015

Cited by 3 publications

(1 citation statement)

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“…Besides making tissue structural part, fibrinogen is considered the major component of the coagulation system. On these lines, it was shown that P. brasiliensis conidia are capable to aggregate in the presence of fibrinogen and human plasma (containing fibrinogen), and the addition of anticoagulants and metabolic and protein inhibitors diminished the aggregation process; moreover, the intrinsic coagulation pathway was markedly altered when conidia were in contact previously with plasma 40 . These results suggest that P. brasiliensis conidia interact with the coagulation system, process that could be important not only during their initial recognition, but also during the inflammatory response development and subsequent establishment of the disease.…”

Section: In Vitro Interactions Among Host Molecules and mentioning

confidence: 99%

THE POWER OF THE SMALL: THE EXAMPLE OF Paracoccidioides brasiliensis CONIDIA

Restrepo

Cano

González

2015

Rev. Inst. Med. trop. S. Paulo

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SUMMARYResearch on Paracoccidioides brasiliensis has centered in the yeast cell probably because of the lack of distinctive features in the mycelium. In 1942 and for the first time, lateral conidia were noticed in the fungus' hyphae. Later on, Brazilian, Venezuelan and Argentinean researchers described "aleurias" when the fungus was grown in natural substrates. In 1970 authors became interested in the conidia and were able to obtain them in large numbers and treat them as individual units. Their shape and size were defined and the presence of all the elements of a competent eukaryotic cell were demonstrated. Conidia exhibited thermal dimorphism and, additionally, when given intranasally to BALB/c male mice, they converted into yeasts in the lungs and produce progressive pulmonary lesions with further dissemination to other organs. Studies on the phagocyte-conidia interaction were revealing and showed that these versatile structures allow a better understanding of the host- P. brasiliensis interactions.

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Section: In Vitro Interactions Among Host Molecules and mentioning

confidence: 99%