Repercussões cardíacas após infarto do miocárdio em ratas submetidas previamente a exercício físico

Veiga, Eduardo Carvalho de Arruda; Portes, Leslie Andrews; Bocalini, Danilo Sales; Antônio, Ednei Luiz; Santos, Almira Alves dos; Santos, Marília Higuchi; Silva, Flávio André; Tucci, Paulo José Ferreira

doi:10.1590/s0066-782x2012005000117

Cited by 10 publications

(2 citation statements)

References 35 publications

(41 reference statements)

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“…In the current study, there were no statistically significant differences in cardiac mass of the right and left ventricles between groups, consistent with our previous findings (Veiga et al, 2011, 2013). However, nuclear volume, a more appropriate index of myocardial hypertrophy (Mill et al, 2011; Bajgelmen et al, 2015), indicated attenuation of hypertrophy in the exercised groups compared with the sedentary groups.…”

Section: Discussionsupporting

confidence: 93%

Delayed Reperfusion—Coronary Artery Reperfusion Close to Complete Myocardial Necrosis Benefits Remote Myocardium and Is Enhanced by Exercise

et al. 2019

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The present study aimed to analyze the effects of reperfusion of a distant coronary artery on cardiac function, the ultrastructure, and the molecular environment of the remote myocardium immediately after the completion of myocardial regional necrosis: delayed reperfusion (DR). Additionally, the effects of prior exercise on the outcomes of DR were investigated. Female rats with permanent occlusion or delayed reperfusion were randomly assigned to an exercise (swimming, 1 h/day, 5 days/week for 8 weeks) or sedentary protocol. Thus, the study included the following four groups: sedentary permanent occlusion, exercise permanent occlusion, sedentary delayed reperfusion, and exercise delayed reperfusion. The descending coronary artery was occluded for 1 h. Reperfusion was confirmed by contrast echocardiography, and the rats were observed for 4 weeks. Permanent occlusion and DR caused similar myocardial infarction sizes among the four groups. Interestingly, exercise significantly decreased the mortality rate. Delayed reperfusion resulted in significant benefits, including enhanced hemodynamics and papillary muscle contraction, as well as reduced apoptosis and collagen content. Protein calcium kinetics did not change. Meanwhile, developed tension and the Frank–Starling mechanism were enhanced, suggesting that calcium sensitivity was intensified in myofilaments. Remarkable remote myocardial benefits occurred after distant DR, and prior exercise intensified cardiac recovery. Our findings provide valuable information about DR. Our data might explain the better clinical outcomes in recent studies showing that late reperfusion could improve heart failure in patients with myocardial infarction. In conclusion, DR has remote myocardial benefits, including inotropism enhancement, pulmonary congestion reduction, and collagen and apoptosis attenuation, which are enhanced by prior exercise.

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Section: Discussionsupporting

confidence: 93%

Delayed Reperfusion—Coronary Artery Reperfusion Close to Complete Myocardial Necrosis Benefits Remote Myocardium and Is Enhanced by Exercise

et al. 2019

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“…The authors have suggested that even a short period of training is sufficient to induce cardiac protection. In contrast, Veiga et al [38] have not observed any differences on morphological parameters, cardiac function nor on the tension of the papillary muscles in swimming trained female rats prior to MI. It is possible that the observed differences between these findings and the results of the present study are due to the type of training performed (swimming vs. treadmill), as well as to the gender of the chosen animals (females vs. males).…”

Section: Discussionmentioning

confidence: 86%

Cardioprotection afforded by exercise training prior to myocardial infarction is associated with autonomic function improvement

Rodrigues

Feriani

Barboza

et al. 2014

BMC Cardiovasc Disord

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BackgroundIt has been suggested that exercise training (ET) protects against the pathological remodeling and ventricular dysfunction induced by myocardial infarction (MI). However, it remains unclear whether the positive adjustments on baroreflex and cardiac autonomic modulations promoted by ET may afford a cardioprotective mechanism. The aim of this study was to evaluate the effects of aerobic ET, prior to MI, on cardiac remodeling and function, as well as on baroreflex sensitivity and autonomic modulation in rats.MethodsMale Wistar rats were divided into 4 groups: sedentary rats submitted to Sham surgery (C); trained rats submitted to Sham surgery (TC); sedentary rats submitted to MI (I), trained rats submitted to MI (TI). Sham and MI were performed after ET period. After surgeries, echocardiographic, hemodynamic and autonomic (baroreflex sensitivity, cardiovascular autonomic modulation) evaluations were conducted.ResultsPrior ET prevented an additional decline in exercise capacity in TI group in comparison with I. MI area was not modified by previous ET. ET was able to increase the survival and prevent additional left ventricle dysfunction in TI rats. Although changes in hemodynamic evaluations were not observed, ET prevented the decrease of baroreflex sensitivity, and autonomic dysfunction in TI animals when compared with I animals. Importantly, cardiac improvement was associated with the prevention of cardiac autonomic impairment in studied groups.ConclusionsPrior ET was effective in changing aerobic capacity, left ventricular morphology and function in rats undergoing MI. Furthermore, these cardioprotective effects were associated with attenuated cardiac autonomic dysfunction observed in trained rats. Although these cause-effect relationships can only be inferred, rather than confirmed, our study suggests that positive adaptations of autonomic function by ET can play a vital role in preventing changes associated with cardiovascular disease, particularly in relation to MI.

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Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats

Ruberti

Sousa

Viana

et al. 2020

Journal Cellular Physiology

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This study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female Wistar rats were ovariectomized and divided into four groups: sedentary + sham (SS), sedentary + MI (SI), AT + sham surgery (TS), AT + MI (TI). AT was performed on a treadmill for 8 weeks before MI. Infarcted rats previously subjected to AT presented improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis identified and quantified 62 metabolites, 9 were considered significant by the Vip Score. SS, SI, and TS groups presented distinct metabolic profiles; however, TI could not be distinguished from the SS group. MI dramatically increased levels of dimethylamine, and AT prevented this response. Our findings suggest that AT may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI in ovariectomized rats.

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Repercussões cardíacas após infarto do miocárdio em ratas submetidas previamente a exercício físico

Abstract: Background: Few studies have analyzed the cardiac effects of exercise prior to coronary occlusion.

Cited by 10 publications

References 35 publications

Delayed Reperfusion—Coronary Artery Reperfusion Close to Complete Myocardial Necrosis Benefits Remote Myocardium and Is Enhanced by Exercise

Delayed Reperfusion—Coronary Artery Reperfusion Close to Complete Myocardial Necrosis Benefits Remote Myocardium and Is Enhanced by Exercise

Cardioprotection afforded by exercise training prior to myocardial infarction is associated with autonomic function improvement

Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats

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