Papel do ecocardiograma na avaliação ventricular do coração transplantado versus rejeição cardíaca

Miguel, Gabriel Antonio Stanisci; Rojas, Salomón Soriano Ordinola; Vieira, Reinaldo Wilson; Silva, José Pedro da; Abensur, Henry

doi:10.1590/s0066-782x2012005000099

Cited by 1 publication

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References 21 publications

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“…Miguel et al discovered IMP in HTX patients with and without rejection were significantly higher than that in healthy control group. In addition, IMP in HTX patients with rejection was higher than that in HTX patients without rejection, but not reaching statistical level, [ 49 ]. Burgess et al demonstrated an absence of significant change in IMP between rejection group and Non-rejection group.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Performance of Echocardiography for the Detection of Acute Cardiac Allograft Rejection: A Systematic Review and Meta-Analysis

et al. 2015

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ObjectiveMany studies have addressed the diagnostic performance of echocardiography to evaluate acute cardiac allograft rejection compared with endomyocardial biopsy. But the existence of heterogeneity limited its clinical application. Thus, we conducted a comprehensive, systematic literature review and meta-analysis for the purpose.MethodsStudies prior to September 1, 2014 identified by Medline/PubMed, EMBASE and Cochrance were examined by two independent reviews. We conducted meta-analysis by using Meta-DiSc 1.4 software. An assessment tool of QUADAS-2 was applied to evaluate the risk of bias and applicability of the studies.ResultsThirty studies met the inclusion criteria of meta-analysis. The four parameters of pressure half time, isovolumic relaxation time, index of myocardial performance and late diastolic mitral annular motion velocity were included in the meta-analysis, with a pooled diagnostic odds ratio of 10.43, 6.89, 15.95 and 5.68 respectively, and the area under the summary receiver operating characteristic curves value of 0.829, 0.599, 0.871 and 0.685 respectively.ConclusionThe meta-analysis and systematic review demonstrate that no single parameter of echocardiography showed a reliable diagnostic performance for acute cardiac allograft rejection. A result of echocardiography for ACAR should be comprehensively considered by physicians in the context of clinical presentations and imaging feature.

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Section: Discussionmentioning

confidence: 99%