Ponto ótimo cardiorrespiratório: uma variável submáxima do teste cardiopulmonar de exercício

Ramos, Plínio dos Santos; Ricardo, Djalma Rabelo; Araújo, Cláudio Gil Soares de

doi:10.1590/s0066-782x2012005000091

Cited by 32 publications

(31 citation statements)

References 37 publications

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“…In the present study, approximately 20% of patients were unwilling to complete a truly maximal CPX, making submaximal cardiorespiratory data even more relevant. As previously stated, premature CPX interruption tends to do not affect COP determination, since COP occured at about 44% of VO 2 max and so, well before anaerobic threshold and maximal effort [18]. This is further corroborated by the fact that PDG and CG did not have different COP results, and there was no difference in COP when comparing between subgroups of PD patients (Figure 1).…”

Section: Discussionsupporting

confidence: 76%

“…When investigating COP behavior of PD patients (Figure 2) by using a regression equation [18], our results show that COP was about always (except in a single case), within the boundaries of estimate of error for healthy subjects. Therefore, it was observed that, from the point of view of cardiorespiratory integration, reflecting, at least partially, the quality of ventilation-perfusion ratio during exercise, PD patients exhibit no limitations and behave similarly to healthy subjects.…”

Section: Discussionmentioning

confidence: 80%

“…Regarding COP results, except for one case (normality threshold value) all other 51 PD patients (98% of the total) had results that felt within the boundaries of two standard errors from the expected COP age-and-sex reference value [18]. (Figure 2).…”

Section: Resultsmentioning

confidence: 93%

“…The identification of COP is quite simple, objective, and independent from the evaluator's judgment. COP reference values for a wide age range among men and women are already available favoring its interpretation [18] and its measurement has been shown to be reliable in two separate CPX performed in the same subjects [26].…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we have used a recently proposed submaximal exercise variable, the cardiorespiratory optimal point (COP) [18], which represents the minimal ventilation (VE)/oxygen uptake (VO 2 ) value and reflects the best circulatory-respiratory interaction, to assess exercise ventilatory response in PD patients. So, in order to test the hypothesis that the exercise-related respiratory symptoms in PD patients are not due to a true abnormal cardiorespiratory interaction, we compared COP during CPX in PD patients and age and gender-matched healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

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Cardiorespiratory Optimal Point: A Submaximal Exercise Variable to Assess Panic Disorder Patients

Ramos¹,

Sardinha

Nardi

et al. 2014

PLoS ONE

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Panic disorder (PD) patients often report respiratory symptoms and tend to perform poorly during maximal cardiopulmonary exercise testing (CPX), at least partially, due to phobic anxiety. Thus, we hypothesized that a submaximal exercise variable, minimum VE/VO2 - hereafter named cardiorespiratory optimal point (COP) -, may be useful in their clinical assessment. Data from 2,338 subjects were retrospectively analyzed and 52 (2.2%) patients diagnosed with PD (PDG) (70% women; aged 48±13 years). PD patients were compared with a healthy control group (CG) precisely matched to number of cases, age and gender profiles. PDG was further divided into two subgroups, based on having achieved a maximal or a submaximal CPX (unwilling to continue until exhaustion). We compared COP, VO2 max, maximum heart rate (HR max) between PDG and CG, and also COP between maximal and submaximal PD subgroups. COP was similar between PDG and CG (21.9±0.5 vs. 23.4±0.6; p = 0.07), as well as, for PD subgroups of maximal and submaximal CPX (22.0±0.5 vs. 21.6±1.3; p = 0.746). Additionally, PD patients completing a maximal CPX obtained VO2 max (mL.kg−1.min−1) (32.9±1.57 vs 29.6±1.48; p = 0.145) and HR max (bpm) similar to controls (173±2.0 vs 168±2.7; p = 0.178). No adverse complications occurred during CPX. Although clinically safe, it is sometimes difficult to obtain a true maximal CPX in PD patients. Normalcy of cardiorespiratory interaction at submaximal effort as assessed by COP may contribute to reassure both patients and physicians that there is no physiological substrate for exercise-related respiratory symptoms often reported by PD patients.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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