Relação entre o Paratormônio e Depressão na insuficiência cardíaca

Altay, Hakan; Zorlu, Ali; Kocum, Halil Tolga; Demircan, Şenol; Yılmaz, Nuryil; Yılmaz, Mehmet

doi:10.1590/s0066-782x2012005000088

Cited by 7 publications

(5 citation statements)

References 28 publications

(22 reference statements)

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“…Patients with depressive symptoms have lower heart rate variability, 30, 31 a higher inflammatory response, 32 hyperactivity of sympathetic nervous system, greater severity of HF, 29 higher platelet activity, and more frequent myocardial ischemia which may explain, in part, worse outcomes. 33 In the current HF literature, NYHA classification has been found to be related to depressive symptoms 34–36 and survival 37, 38 in patients with HF, and also been used to assess HF severity. 39, 40 In our study, patients with depressive symptoms were more likely to have advanced HF as reflected by NYHA functional class compared with those without depressive symptoms.…”

Section: Discussionmentioning

confidence: 99%

Medication Adherence, Depressive Symptoms, and Cardiac Event–Free Survival in Patients With Heart Failure

Lennie

Dekker

et al. 2013

Journal of Cardiac Failure

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Background Medication nonadherence and depressive symptoms predict hospitalization and death in patients with heart failure (HF). Depressed patients have lower medication adherence than non-depressed patients. However, the predictive power of the combination of medication adherence and depressive symptoms for hospitalization and death has not been investigated in patients with HF. Objective To explore the combined influence of medication adherence and depressive symptoms for prediction of cardiac event-free survival in patients with HF. Method We monitored medication adherence in 216 HF patients who completed the Patient Health Questionnaire-9 (PHQ-9) at baseline. Medication adherence was measured objectively using Medication Event Monitoring System (MEMS). Patients were followed for up to 3 1/2 years to collect data on cardiac event(s). Survival analyses were used to compare cardiac event-free survival between/among groups. Results The risk of experiencing a cardiac event for patients with medication nonadherence and depressive symptoms was 5 times higher compared to those who were medication adherent without depressive symptoms. The risk of experiencing a cardiac event for patients with only one risk factor was 1.2–1.3 times that of those with neither risk factor. Conclusion Medication nonadherence and depressive symptoms had a negative synergistic effect on cardiac event-free survival in patients with HF.

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Section: Discussionmentioning

confidence: 99%

Medication Adherence, Depressive Symptoms, and Cardiac Event–Free Survival in Patients With Heart Failure

Lennie

Dekker

et al. 2013

Journal of Cardiac Failure

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“…The sample was calculated based on moderate and/or severe BDI scores (BDI>18) of 51% in a previous study (1). Considering the population served in centers 1 (120 patients), 2 (150 patients) and 3 (700 patients), with a 95% confidence level and a margin of error of 5%, we will include 276 patients in this study.…”

Section: Sample Calculationmentioning

confidence: 99%

“…Since this disorder is a predictor of the quality of life (1) , we suggest that a longitudinal follow-up may indicate the likelihood of the occurrence of depression in HF patients. This study's hypothesis is that serotonin and BDNF, when evaluated prospectively, may be, in heart failure, markers of depression or risk factors.…”

Section: Introductionmentioning

confidence: 97%

“…Heart failure (HF) is a disease that is highly prevalent worldwide (1) . One study has demonstrated that depressed subjects have lower levels of the Brain-Derived Neurotrophic Factor (BDNF) than a control group.…”

Section: Introductionmentioning

confidence: 99%

“…To assess the symptoms of depression, the Beck Depression Inventory (BDI) is currently used to discriminate between healthy individuals and the depressed or anxious (1) .…”

Section: Introductionmentioning

confidence: 99%

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Serotonin biomarkers and brain-derived neurotrophic factors in heart failure: a prospective cohort

Guerra

Venâncio

Vieira³

et al. 2014

Online Brazilian Journal of Nursing

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Aim: To analyze the prognostic of serotonin biomarkers and brain-derived neurotrophic factors (BDNF) on depression in patients with systolic heart failure. Method: An observational, multicenter, prospective cohort study in three specialized centers, from April 2014 to November 2016. Study protocol: multidisciplinary medical consultation, depression inventory, quality of life questionnaire and blood test to measure serotonin and BDNF, with analysis via high performance liquid chromatography and ELISA, respectively. In order to study the association of these markers with the analytical methods used, a statistical evaluation will be carried out using the chi-square test and the Pearson correlation coefficient. For the analysis of mortality and hospitalization, logistic regression and analysis of mortality risk will be used. The statistical significance is 5%. Expected results: biological markers are more effective than conventional tests (questionnaires) when used to identify the degree of depression.

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Levels of 25-hydroxyvitamin D3, biochemical parameters and symptoms of depression and anxiety in healthy individuals

et al. 2019

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Relação entre o Paratormônio e Depressão na insuficiência cardíaca

Abstract: Background: Depression has been found to be a predictor of rehospitalization and mortality in heart failure (HF). Parathyroid hormone (PTH) is a novel promising biomarker that can predict hospitalization, functional status and mortality in HF.

Cited by 7 publications

References 28 publications

Medication Adherence, Depressive Symptoms, and Cardiac Event–Free Survival in Patients With Heart Failure

Medication Adherence, Depressive Symptoms, and Cardiac Event–Free Survival in Patients With Heart Failure

Serotonin biomarkers and brain-derived neurotrophic factors in heart failure: a prospective cohort

Levels of 25-hydroxyvitamin D3, biochemical parameters and symptoms of depression and anxiety in healthy individuals

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