Ausência de estreita associação entre qualidade de vida e capacidade de exercício na hipertensão arterial pulmonar

Cícero, Cristina; Franchi, Sônia Meiken; Barreto, Alessandra Costa; Lopes, Antônio Augusto

doi:10.1590/s0066-782x2012005000079

Cited by 7 publications

(7 citation statements)

References 33 publications

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“…Table 2 shows the mean values obtained in the physical capacity assessment related to cardiopulmonary exercise test and 6MWT, and the mean predicted values 17 , 18 .…”

Section: Resultsmentioning

confidence: 99%

“…Cicero et al 18 have assessed 34 patients in functional classes II and III, whose initial median walked distance was 399 (117-564) m. However, the group studied included no group IV patient.…”

Section: Discussionmentioning

confidence: 99%

“…When assessing QOL, we observed that the patients perceived reduced values, and we used a generic questionnaire (SF-36) because of the lack of a specific questionnaire for PH validated in Portuguese 18 .…”

Section: Discussionmentioning

confidence: 99%

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Association Between Hemodynamic Profile, Physical Capacity and Quality of Life in Pulmonary Hypertension

Torres¹,

Zin²,

Lopes³

et al. 2015

Arquivos Brasileiros De Cardiologia

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BackgroundNo studies have described and evaluated the association between hemodynamics, physical limitations and quality of life in patients with pulmonary hypertension (PH) without concomitant cardiovascular or respiratory disease.ObjectiveTo describe the hemodynamic profile, quality of life and physical capacity of patients with PH from groups I and IV and to study the association between these outcomes.MethodsCross-sectional study of patients with PH from clinical groups I and IV and functional classes II and III undergoing the following assessments: hemodynamics, exercise tolerance and quality of life.ResultsThis study assessed 20 patients with a mean age of 46.8 ± 14.3 years. They had pulmonary capillary wedge pressure of 10.5 ± 3.7 mm Hg, 6-minute walk distance test (6MWDT) of 463 ± 78 m, oxygen consumption at peak exercise of 12.9 ± 4.3 mLO2.kg-1.min-1 and scores of quality of life domains < 60%. There were associations between cardiac index (CI) and ventilatory equivalent for CO2 (r=-0.59, p <0.01), IC and ventilatory equivalent for oxygen (r=-0.49, p<0.05), right atrial pressure (RAP) and 'general health perception' domain (r=-0.61, p<0.01), RAP and 6MWTD (r=-0.49, p<0.05), pulmonary vascular resistance (PVR) and 'physical functioning' domain (r=-0.56, p<0.01), PVR and 6MWTD (r=-0.49, p<0.05) and PVR index and physical capacity (r=-0.51, p<0.01).ConclusionPatients with PH from groups I and IV and functional classes II and III exhibit a reduction in physical capacity and in the physical and mental components of quality of life. The hemodynamic variables CI, diastolic pulmonary arterial pressure, RAP, PVR and PVR index are associated with exercise tolerance and quality of life domains.

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“…Table 2 shows the mean values obtained in the physical capacity assessment related to cardiopulmonary exercise test and 6MWT, and the mean predicted values 17 , 18 .…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association Between Hemodynamic Profile, Physical Capacity and Quality of Life in Pulmonary Hypertension

Torres¹,

Zin²,

Lopes³

et al. 2015

Arquivos Brasileiros De Cardiologia

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“…Four studies examined QoL with serial follow-up in CHD. They identified psychosocial determinants of baseline and serial QoL [ 22 , 23 ], analysed associations between QoL and exercise capacity over time [ 24 ] and provided insight into the longitudinal course of QoL [ 25 ]. None of these studies evaluated mortality.…”

Section: Discussionmentioning

confidence: 99%

Decrease in quality of life predicts mortality in adult patients with pulmonary arterial hypertension due to congenital heart disease

et al. 2015

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BackgroundDecrease in quality of life (QoL) in left-sided heart failure precedes poor survival, which can be reversed with exercise training. We investigated whether QoL is associated with mortality in pulmonary arterial hypertension due to congenital heart disease (PAH-CHD) patients.MethodsIn this observational study, PAH-CHD adults referred for PAH-specific therapy were included. QoL surveys (SF36) were recorded during 2 years of therapy. Based on shift in SF36 scores during this period, patients had either decreased or non-decreased QoL. Subsequently, the patients were followed for mortality.ResultsThirty-nine PAH-CHD patients (mean age 42, 44 % male, 49 % Down’s syndrome) were analysed. Following PAH-specific therapy, SF36 physical component summary (PCS) decreased in 13 (35–31 points, p = 0.001) and showed no decrease in 26 patients (34–43 points, mean values, p < 0.001). Post-initiation phase, median follow-up was 4.5 years, during which 12 deaths occurred (31 %), 10 (56 %) in the decreased and 2 (10 %) in the non-decreased group (p = 0.002). Cox regression showed a decrease in SF36 PCS predicted mortality (HR 3.4, 95 % CI 1.03–11, p = 0.045).ConclusionsIn PAH-CHD patients, decrease in SF36 PCS following initiation of PAH-specific therapy is a determinant of mortality.Electronic supplementary materialThe online version of this article (doi:10.1007/s12471-015-0666-9) contains supplementary material, which is available to authorized users.

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“…Despite some progress in understanding the physiopathology of the disease and the discovery of new treatments in recent decades, pulmonary hypertension is still a disease with poor prognosis 2 . Non-invasive markers to better assess the severity of the disease and that may help determine which patients require more aggressive treatments are needed.…”

mentioning

confidence: 99%

Delayed Myocardial Enhancement by Cardiac Magnetic Resonance Imaging in Pulmonary Arterial Hypertension: A Marker of Severity of Disease

Rochitte¹,

Hoette²,

Souza³

2013

Arquivos Brasileiros De Cardiologia

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Ausência de estreita associação entre qualidade de vida e capacidade de exercício na hipertensão arterial pulmonar

Abstract: Background: In pulmonary arterial hypertension (PAH) health-related quality of life (HRQOL) has been investigated over the short-term (weeks) but little is known about patient's perspective over the medium and long term.

Cited by 7 publications

References 33 publications

Association Between Hemodynamic Profile, Physical Capacity and Quality of Life in Pulmonary Hypertension

Association Between Hemodynamic Profile, Physical Capacity and Quality of Life in Pulmonary Hypertension

Decrease in quality of life predicts mortality in adult patients with pulmonary arterial hypertension due to congenital heart disease

Delayed Myocardial Enhancement by Cardiac Magnetic Resonance Imaging in Pulmonary Arterial Hypertension: A Marker of Severity of Disease

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