Expressão imunoistoquímica de diferenciação e crescimento celular em cardiomiócitos de neonatos

Abstract

Background: The cardiac alterations during the fetal heart transition to extrauterine life have been explored by several animal studies and the cell mechanisms responsible for these modifications are not well documented in humans.

A change of heart: understanding the mechanisms regulating cardiac proliferation and metabolism before and after birth

“…Neuregulin-1 was able to induce CM proliferation in intact cultured myocardium from infants with heart disease who were less than 6 months of age (Polizzotti et al, 2015). Other reports indicate that CMs can still proliferate at 10 years of age (Bergmann et al, 2015), with CM proliferation observed in 3-month-old hearts (Amir et al, 2008;Huttenbach et al, 2001;Silva et al, 2012;Ye et al, 2016).…”

“…At the same time, CMs enter cell cycle arrest and become binucleated, cardiac fibroblasts produce collagen-rich extracellular matrix (ECM) and OXPHOS becomes the main form of ATP production (Lopaschuk et al, 1992;Notari et al, 2018). (Amir et al, 2008;Bergmann et al, 2009;Bergmann et al, 2015;Huttenbach et al, 2001;Kim et al, 1992;Mollova et al, 2013;Schmid & Pfitzer, 1985;Silva et al, 2012) d GA, days of gestation.…”