Valor prognóstico do peptídeo natriurético tipo B na mortalidade de pacientes com Síndrome Coronariana Aguda

Scotti, Alexandre Vaz; Tura, Bernardo Rangel; Rocha, Ronilson Gonçalves; Albuquerque, Denílson Campos de

doi:10.1590/s0066-782x2012005000050

Cited by 7 publications

(7 citation statements)

References 28 publications

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“…However, the prognostic value of BNP in ACS has not been well established, although it has been repeatedly assessed. According to current understanding, baseline BNP measurement in ACS patients is an important risk stratification tool [47]; the findings of our study support this notion.…”

Section: Discussionsupporting

confidence: 83%

Prognostic value of low and moderately elevated C-reactive protein in acute coronary syndrome: A 2-year follow-up study

et al. 2013

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BackgroundThe main goal of this study was to improve diagnostic and predictive value of low and moderately elevated C-reactive protein (CRP) in patients with acute coronary syndrome (ACS), related to noninvasive clinical parameters, in order to improve and prolong patient life with low or no additional costs.Material/MethodsA prospective, open clinical study was conducted at the University Hospital Split, Croatia with 112 patients with ACS and low or moderately elevated CRP (<3.0 mg/L). After diagnosing ACS, data on physical activity, alcohol consumption, and functional status were recorded. Anthropometric measurements were made. Blood and urine samples were taken for analyses. Electrocardiographic, ergometric, and echocardiographic testing was performed. A total of 72 parameters were monitored at the time of hospital admission in ACS patients to analyze which ones could predict disease outcome at the end of follow-up in patients with low or moderately elevated CRP. Patients were followed up for 2 years.ResultsThe variables that were predictive of major adverse cardiac events (MACE) within 2 years of ACS hospitalization were hemoglobin, fibrinogen, antithrombin III, cholesterol levels, brain natriuretic peptide, and microalbuminuria. ACS patients with CRP <3.0 mg/L had significantly higher risk of developing MACE within 2 years if ≥50% of the 8 key parameters were outside the reference values.ConclusionsMajor adverse cardiac events can be predicted in patients with acute coronary syndrome whose CRP values are low or moderately elevated.

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Section: Discussionsupporting

confidence: 83%

Prognostic value of low and moderately elevated C-reactive protein in acute coronary syndrome: A 2-year follow-up study

et al. 2013

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“…The previous investigation confirmed the diagnostic and prognostic importance of BNP in patients with HF (26). However, a recent study showed the significant association of BNP with higher longterm mortality risk in patients diagnosed with ACS (27). In ACS patients, levels of BNP are likely increasing due to stiffening of left ventricular as a result of myocardial ischemia.…”

Section: Discussionmentioning

confidence: 70%

Role of interleukin-18 and plasma B-type natriuretic peptide in predicting requirement of kidney replacement therapy and/or mortality in individuals with acute heart disorders

et al. 2019

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Introduction: Although many predictive tools have already been developed, efforts are still proceeding to identify a reliable biomarker to predict the prognosis of the patients with acute heart disorders. Objectives: The aim was to evaluate the role of renal injury biomarkers (serum cystatin C, serum and urine interleukin-18, IL-18) and heart failure biomarkers (plasma B-type natriuretic peptide, BNP) in the prediction of the postdischarge requirement of renal replacement therapy (RRT) and/or 6-month mortality in patients with acute heart disorders. Patients and Methods: In patients diagnosed with acute heart disorders (acute heart failure [AHF] and/or acute coronary syndrome [ACS]) and admitted to the intensive care units, baseline clinical parameters, renal and cardiac biomarkers were determined. Patients were followed up for 6 months. The composite outcome was the postdischarge requirement of RRT and/or 6-month mortality. Results: Of 120 patients, 5.8% continued RRT after discharge. The 6-month mortality was 20%. Cox logistic regression analysis showed that urine IL-18 (P=0.021), plasma BNP (P=0.046), Acute Physiology and Chronic Health Evaluation (APACHE) II score (P=0.002), and left ventricular diastolic dysfunction (P=0.045) were independent predictors of the postdischarge requirement of RRT and/or 6-month mortality. For predicting RRT and/or 6-month mortality, using urine IL-18 cutoff value of 29.1 pg/mL showed 66.7% sensitivity and 67.7% specificity (area under the curve, AUC 0.70, P=0.003), while using plasma BNP cutoff value of 881.6 pg/mL showed 66.7% sensitivity and 70.8% specificity (AUC 0.76, P<0.001). Conclusion: Urine IL-18 and plasma BNP are independently predictive for the postdischarge requirement of RRT and/or 6-month mortality in patients with acute heart disorders.

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“…No entanto, outros estudos usaram ou encontraram valores mais altos de BNP para demonstrar relação com prognóstico em SCA. Scotti et al 8 acompanharam 40 pacientes com SCA sem supradesnível de ST e troponina positiva e mensuraram o BNP na chegada e após 96 horas da admissão. Usando um cutoff de 300 pg/mL, os autores mostraram que o BNP foi forte preditor de mortalidade em quatro anos de seguimento com área sob a curva de 0,92.…”

Section: Discussionunclassified

“…Usando um cutoff de 300 pg/mL, os autores mostraram que o BNP foi forte preditor de mortalidade em quatro anos de seguimento com área sob a curva de 0,92. Além disso, demonstrou-se um risco relativo de morte 7,4 vezes maior naqueles com BNP acima de 300 pg/mL (p < 0,01) 8 .…”

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Valores intermediários de BNP são capazes de predizer eventos em pacientes com síndrome coronária aguda?

Soeiro

Roque

Póvoa

et al. 2016

Rev. Med. (São Paulo)

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Valor prognóstico do peptídeo natriurético tipo B na mortalidade de pacientes com Síndrome Coronariana Aguda

Cited by 7 publications

References 28 publications

Prognostic value of low and moderately elevated C-reactive protein in acute coronary syndrome: A 2-year follow-up study

Prognostic value of low and moderately elevated C-reactive protein in acute coronary syndrome: A 2-year follow-up study

Role of interleukin-18 and plasma B-type natriuretic peptide in predicting requirement of kidney replacement therapy and/or mortality in individuals with acute heart disorders

Valores intermediários de BNP são capazes de predizer eventos em pacientes com síndrome coronária aguda?

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