A Deficiência de vitamina d está associada com níveis aumentados de il-17 e tnfα em pacientes com insuficiência cardíaca crônica

Milovanović, M; Pesic, Gordana; Nikolić, Valentina; Jevtović-Stoimenov, Tatjana; Vasic, K.; Jović, Zorica; Deljanin-Ilić, Marina; Pesic, Srdjan

doi:10.1590/s0066-782x2012005000019

Cited by 17 publications

(8 citation statements)

References 32 publications

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“…In a population whose degenerative joint condition is mediated in part by pro-inflammatory cytokines, it appears that low vitamin D does not increase inflammatory cytokines in the blood. This finding, however, conflicts with results showing a circulating increase of pro-inflammatory cytokines in young reportedly healthy adults [36], obese adults [37], chronic heart failure patients [38], and type 2 diabetics [39] with low serum 25(OH)D concentrations. Further, a pro-inflammatory cytokine increase in the blood associates with muscular weakness and impaired physical mobility in elderly [67–70], the development of knee OA [28,71], and muscular weakness in patients with knee OA [9].…”

Section: Discussioncontrasting

confidence: 70%

Vitamin D deficiency associates with γ-tocopherol and quadriceps weakness but not inflammatory cytokines in subjects with knee osteoarthritis

Barker

Henriksen²,

Rogers³

et al. 2014

Redox Biology

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Knee osteoarthritis (OA) is a degenerative joint condition and a leading cause of physical disability in the United States. Quadriceps weakness and inflammatory cytokines contribute to the pathogenesis of knee OA, and both of which, increase with vitamin D deficiency. Other micronutrients, such as vitamins C and E and β-carotene, modulate inflammatory cytokines and decrease during inflammation. The purpose of this study was to test the hypothesis that vitamin D deficiency associates with quadriceps weakness, an increase in serum cytokines, and a decrease in circulating micronutrients in subjects with knee OA. Subjects (age, 48±1 y; serum 25(OH)D, 25.8±1.1 ng/mL) with knee OA were categorized as vitamin D deficient (n=17; serum 25(OH)D≤20 ng/mL), insufficient (n=21; serum 25(OH)D 20–29 ng/mL), or sufficient (n=18; serum 25(OH)D≥30 ng/mL). Single-leg strength (concentric knee extension–flexion contraction cycles at 60 °/s) and blood cytokine, carotene (α and β), ascorbic acid, and tocopherol (α and γ) concentrations were measured. Quadriceps peak torque, average power, total work, and deceleration were significantly (all p<0.05) impaired with vitamin D deficiency. Serum γ-tocopherol concentrations were significantly (p<0.05) increased with vitamin D deficiency. In the vitamin D sufficient group, γ-tocopherol inversely correlated (r=−0.47, p<0.05) with TNF-α, suggesting a pro-inflammatory increase with a γ-tocopherol decrease despite a sufficient serum 25(OH)D concentration. We conclude that vitamin D deficiency is detrimental to quadriceps function, and in subjects with vitamin D sufficiency, γ-tocopherol could have an important anti-inflammatory role in a pathophysiological condition mediated by inflammation.

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Section: Discussioncontrasting

confidence: 70%

Vitamin D deficiency associates with γ-tocopherol and quadriceps weakness but not inflammatory cytokines in subjects with knee osteoarthritis

Barker

Henriksen²,

Rogers³

et al. 2014

Redox Biology

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“…Even in rats with established ischemic cardiomyopathy, physical training was able to restore the Treg population and mitigate the production of IL-6, TNF-α, and later IL-17 in peripheral blood ( 21 ). Catechin, a cardioprotective agent, and 25-hydroxy vitamin D, have been reported to exert the same effect by regulating the balance between IL-17/IL-10 production in mouse models of ischemic cardiomyopathy ( 13 , 22 ).…”

Section: Discussionmentioning

confidence: 99%

Association of levels of interleukin 17 and T-helper 17 count with symptom severity and etiology of chronic heart failure: a case-control study

et al. 2018

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AimTo assess the association between the levels of interleukin 17 (IL-17) and T-helper 17 count and symptom severity and etiology of chronic heart failure.MethodsThis single-center prospective case-control study, conducted from December 1, 2015 to January 1, 2017 in Tehran Heart Center, evaluated gene expression of IL-17, relative count of (CD4+IL17+) Th17 cells and CD4+ helper T-cells in peripheral blood mononuclear cells of 42 patients with CHF and 42 matched controls. A multiple regression model assessed the predictors of peripheral IL-17 expression and Th17 count in patients with CHF.ResultsIL-17 expression was increased in patients with CHF, both at baseline and after stimulation. IL-17 and Th17 counts were higher in patients with advanced New York Heart Association (NYHA) functional class (class IV) than in controls and patients with class I. Th17 cell population expanded in patients with CHF, more prominently in patients with class IV than in controls and patients with class I, regardless of the ischemic or non-ischemic CHF origin. Multiple regression model showed that NYHA was the only meaningful predictor of IL-17 levels and Th17 count.ConclusionWe demonstrated the lymphocytic origin of IL-17 production in advanced CHF and the ability of disease severity to predict IL-17 levels.Oxford Centre for Evidence-based Medicine level of evidence: 3.

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“…Activated VDR binds response elements on DNA that are associated with antimicrobial [ 3 ] and immune regulatory functions [ 4 ]. Thus, vitamin D deficiency might result in the impaired function of immune cells [ 5 ] and cytokine imbalance [ 6 , 7 ]. It has also been observed that sufficient 25(OH)D levels are related to increasing concentrations of IL-4 and IL-10 and to low levels of proinflammatory cytokines such as IL-1, IL-6, IL-12, IL-17, IL-23, and IFN- γ [ 3 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults

Elizondo‐Montemayor

Castillo

López

et al. 2017

Mediators of Inflammation

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Vitamin D deficiency is present even in sunny regions. Ageing decreases pre-vitamin D production in the skin and is associated with altered cytokine profile. We performed a multivariate analysis considering lifestyle factors, anthropometric, and inflammatory markers according to seasonal variation in Mexican healthy older adults. The same cohort was followed during 12 months. Vitamin D deficiency/insufficiency was found in 91.3% of the subjects despite living in appropriate latitude (25°40′0″N). 25(OH)D levels remained below <30 ng/mL through all seasons. Vitamin D deficiency did not correlate to sun exposure or dietary intake. Gender was the strongest associated factor, explaining a variance of 20%. Waist circumference (WC) greater than 88 cm was a risk factor for vitamin D deficiency. Age (>74 years) combined with WC (>88 cm) and BMI (>32.7) showed a high probability (90%) of vitamin D deficiency. Remarkably, an increase in one centimeter in WC decreased 25(OH)D by 0.176 ng/mL, while an increase in one point BMI decreased 25(OH)D by 0.534 ng/mL. A cutoff point of 74 years of age determined probability of vitamin D hipovitaminosis. Vitamin D deficiency was correlated with TNF-α serum levels, possibly increasing the susceptibility of older adults to a proinflammatory state and its related diseases.

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A Deficiência de vitamina d está associada com níveis aumentados de il-17 e tnfα em pacientes com insuficiência cardíaca crônica

Abstract: Background: Recent studies revealed a strong association between vitamin D (VD) status and chronic heart failure (CHF). It is now commonly considered that proinflammatory immune response underlies CHF development.

Cited by 17 publications

References 32 publications

Vitamin D deficiency associates with γ-tocopherol and quadriceps weakness but not inflammatory cytokines in subjects with knee osteoarthritis

Vitamin D deficiency associates with γ-tocopherol and quadriceps weakness but not inflammatory cytokines in subjects with knee osteoarthritis

Association of levels of interleukin 17 and T-helper 17 count with symptom severity and etiology of chronic heart failure: a case-control study

Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults

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