Hipertrofia ventricular e mortalidade cardiovascular em pacientes de hemodiálise de baixo nível educacional

Martin, Rosana dos Santos e Silva; Martin, Luís Cuadrado; Franco, Roberto Jorge da Silva; Barretti, Pasqual; Júnior, João Garcia Caramori; Castro, João Henrique; Antunes, Aline de Araujo; Zanati-Basan, Silméia Garcia; Matsubara, Beatriz Bojikian; Martins, Antônio Sérgio

doi:10.1590/s0066-782x2012005000004

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…In another study of cancer mortality in the US [20], education level was strongly and inversely associated with mortality due to all cancers combined in black and white men and in white women. In a study of 113 HD patients, Martin et al [21] observed an association between education level and ventricular hypertrophy. A statistical difference in all-cause and CV-related mortality between the different educational levels was observed at 5.5 years of follow-up.…”

Section: Discussionmentioning

confidence: 99%

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Education Level Is Associated with Mortality in Male Patients Undergoing Maintenance Hemodialysis

Huang¹,

Lin²,

Lin-Tan³

et al. 2013

Blood Purif

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Background: Studies of the correlation between education levels and mortality in hemodialysis (HD) patients are rare. The aim of this multi-center study was to investigate the relationship between education levels and 3-year mortality rates in HD patients. Methods: A total of 935 HD patients from 3 HD centers participated in this 3-year prospective observational study. Education levels were categorized as either less than senior high school and above or equal to senior high school. The causes of death and mortality rates were also analyzed for each subgroup. Results: At the end of the 3-year follow-up period, 164 patients had died. In the male group, forward stepwise Cox regression analysis revealed that age, HD duration, hypertension, creatinine level, serum albumin level ≥3.6 g/dl, anuria, Kt/V_urea, and high education level were significant predictive factors for 3-year mortality rates. Conclusion: This prospective observational study demonstrated that education level was associated with mortality in men undergoing HD.

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Section: Discussionmentioning

confidence: 99%

“…This phenomenon was not observed in the female group (data not shown). Martin et al [21] reported that a low education level was related to CV-related mortality after 5.5 years of follow-up. Thus, among these patients, persistent follow-up may be necessary.…”

Section: Discussionmentioning

confidence: 99%

Education Level Is Associated with Mortality in Male Patients Undergoing Maintenance Hemodialysis

Huang¹,

Lin²,

Lin-Tan³

et al. 2013

Blood Purif

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“…It has been well discussed that a high education level has benefits for reducing mortality in numerous diseases. 34 – 36 In addition, several studies 37 – 39 showed that a high education level is a protective factor in male but not female patients. In our previous study with hemodialysis patients, a high education level was a protective factor for mortality in male but not female patients.…”

Section: Discussionmentioning

confidence: 99%

Impact of Environmental Particulate Matter and Peritoneal Dialysis-related Infection in Patients Undergoing Peritoneal Dialysis

et al. 2014

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In patients undergoing peritoneal dialysis (PD), PD-related infection is a major cause of PD failure and hospital admission. Good air quality is required when dialysate exchange or exit site wound care is performed. To our knowledge, investigation of air pollution as a factor for PD-related infection in patients undergoing dialysis is limited. This study aimed to assess the effect of environmental particulate matter (PM) and other important risk factors on 1-year PD-related infection in patients undergoing PD.A total of 175 patients undergoing PD were recruited in this 1-year retrospective observational study. Differences in environmental PMs (PM10 and PM2.5) were analyzed with respect to the patients’ living areas. The patients undergoing PD were categorized into 2 groups according to PM2.5 exposure: high (n = 61) and low (n = 114). Demographic, hematological, nutritional, inflammatory, biochemical, and dialysis-related data were analyzed. Multivariate binary logistic and multivariate Cox regression analyses were used to analyze 1-year PD-related infection.A total of 175 patients undergoing PD (50 men and 125 women) were enrolled. Thirty-five patients had PD-related infection within 1 year. Multivariate Cox regression analysis showed that high environmental PM2.5 exposure (hazard ratio (HR): 2.0, 95% confidence interval [CI] [1.03–3.91]; P = .04) and female sex (HR: 2.77, 95% CI [1.07–7.19]; P = .03) were risk factors for 1-year PD-related infection.Patients undergoing PD with high environmental PM2.5 exposure had a higher 1-year PD-related infection rate than that in those with low exposure. Therefore, air pollution may be associated with PD-related infection in such patients.

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“…Aging heart changes can produce cardiac diseases, including coronary arteries [11], myocardial infarction, cardiac valves, aortic regurgitation [12, 13]. Without a doubt, LV hypertrophy is related to changes in cardiac morphology including increased myocyte size [14], increased left ventricular wall thickness and decreased fiber density [15, 16]. Once the aging heart experiences extended elevated workload, the left ventricle becomes deficient in pumping adequate blood.…”

Section: Introductionmentioning

confidence: 99%

Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters

Hsieh

et al. 2014

BMC Cardiovasc Disord

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BackgroundAging is associated with physiological or pathological left ventricular hypertrophy (LVH) cardiac changes. Secondhand smoke (SHS) exposure is associated with pathological LVH. The action mechanism in cardiac concentric hypertrophy from SHS exposure is understood, but the transition contributed from SHS exposure is not. To determine whether exposure to SHS has an impact on age-induced LVH we examined young and old hamsters that underwent SHS exposure in a chamber for 30 mins.MethodsMorphological and histological studies were then conducted using hematoxylin and eosin (H&E) and Masson’s trichrome staining. Echocardiographic analysis was used to determine left ventricular wall thickness and function. LVH related protein expression levels were detected by western blot analysis.ResultsThe results showed that both young and aged hamsters exposed to SHS exhibited increased heart weights and left ventricular weights, left ventricular posterior wall thickness and intraventricular septum systolic and diastolic pressure also increased. However, left ventricular function systolic and diastolic pressure deteriorated. H&E and Masson’s trichrome staining results showed LV papillary muscles were ruptured, resulting in lower cardiac function at the myocardial level. LV muscle fiber arrangement was disordered and collagen accumulation occurred. Concentric LVH related protein molecular markers increased only in young hamsters exposed to SHS. However, this declined with hamster age. By contrast, eccentric LVH related proteins increased in aging hamsters exposed the SHS. Pro-inflammatory proteins, IL-6, TNF-α, JAK1, STAT3, and SIRTI expression increased in aging hamsters exposed to SHS.ConclusionsWe suggest that SHS exposure induces a pro-inflammatory response that results in concentric transition to aging eccentric LVH.

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Hipertrofia ventricular e mortalidade cardiovascular em pacientes de hemodiálise de baixo nível educacional

Abstract: The results of this study confirm those of a previous study. In addition, they show that the higher cardiovascular mortality observed in patients with low educational level can be explained by risk factors of biochemical and cardiac morphological origin.

Cited by 6 publications

References 27 publications

Education Level Is Associated with Mortality in Male Patients Undergoing Maintenance Hemodialysis

Education Level Is Associated with Mortality in Male Patients Undergoing Maintenance Hemodialysis

Impact of Environmental Particulate Matter and Peritoneal Dialysis-related Infection in Patients Undergoing Peritoneal Dialysis

Secondhand smoke exposure toxicity accelerates age-related cardiac disease in old hamsters

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