Interação entre as vias de sinalização de receptores serotoninérgicos e Β-adrenérgicos em artéria femoral de ratos

Delbin, Maria Andréia; Silva, Alexandre; Antunes, Edson; Zanesco, Angelina

doi:10.1590/s0066-782x2011005000121

Cited by 2 publications

(2 citation statements)

References 19 publications

(23 reference statements)

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“…After confirming a sufficient contractile response to KPSS, experiments with noradrenaline (10 −5 mol/L) were started to obtain phasic and tonic contractile responses [24]. Since the arteries must be optimally precontracted to assess relaxation responses, a submaximal tone was induced with 10 −6 mol/L serotonin (Ser) [15, 28]. This precontraction agent was then used for all subsequent relaxation studies.…”

Section: Methodsmentioning

confidence: 99%

“…However, opposite findings were also described in the SHR femoral artery [26]. Nevertheless, pharmacological studies using the femoral artery are highly relevant for a better understanding of the pathophysiology of peripheral artery disease (PAD), whose incidence has an increasing tendency in the world population [27, 28] similar to hypertension. Many factors, including hypertension and advancing age, have been implicated in the pathogenesis of PAD [27, 29, 30].…”

Section: Introductionmentioning

confidence: 99%

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Age-Related Alterations in Endothelial Function of Femoral Artery in Young SHR and WKY Rats

Púzserová

Ilovska

Bališ

et al. 2014

BioMed Research International

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The present study was designed to evaluate the effects of vascular aging in juvenescence on endothelial function in femoral arteries and to assess differences between normotensive and hypertensive rats. The aim of the study was to determine if age affected nitric oxide- (NO-) mediated relaxations in normotensive and hypertensive rats. Juvenile (7-week-old) and young adult (22-week-old) male Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) were used in this study. Femoral artery (FA) reactivity was determined by wire myograph and NO synthase activity by conversion of [3H]-L-arginine. During juvenescence systolic blood pressure (tail-cuff) increased significantly only in SHR, while NO synthesis decreased significantly in both strains. Endothelium-dependent relaxations to acetylcholine were reduced in the FA of SHR compared to age-matched WKY at both ages, yet these parameters were unchanged in adult rats compared with juvenile animals. The NO-dependent component of vasorelaxation was markedly reduced, whereas the NO-independent component was increased in adult compared to juvenile rats in both strains. The endothelial dysfunction in SHR at both ages was associated with reduction of NO-independent mechanisms. In conclusion, aging in early periods of life was associated with reduction of vascular NO production and bioavailability in both strains investigated. This reduction was however fully compensated by accentuation of NO-independent mechanisms.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Age-Related Alterations in Endothelial Function of Femoral Artery in Young SHR and WKY Rats

Púzserová

Ilovska

Bališ

et al. 2014

BioMed Research International

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Increased neuroplasticity may protect against cardiovascular disease

Zheng¹,

Zeng

2013

International Journal of Neuroscience

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Neuroplasticity refers to the capacity of the nervous system to modify its organization such that the brain can be shaped by environmental input. Individuals exhibit different degrees of neuroplasticity because of their different courses of growth. Neuroplasticity may thus play a role in individual differences in the treatment of neuropsychiatric diseases. The nervous system monitors and coordinates internal organ function. Thus neuroplasticity may also be associated with the pathogenesis and the treatment of some other diseases besides neuropsychiatric diseases. The cardiovascular system is controlled by the nervous system, mainly by the autonomic nervous system. Stress may lead to depression and cardiovascular disease (CVD). CVD is associated with depression, which is a disorder of decreased neuroplasticity. And the mechanisms of depression and CVD are related. So we conclude that decreased neuroplasticity causes the coexistence of depression with CVD, and increased neuroplasticity may be beneficial against the development of CVD. This theory provides another angle that can explain some of the reported phenomena related to CVD and neuropsychiatry and provide a potential treatment to protect against CVD.

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Interação entre as vias de sinalização de receptores serotoninérgicos e Β-adrenérgicos em artéria femoral de ratos

Cited by 2 publications

References 19 publications

Age-Related Alterations in Endothelial Function of Femoral Artery in Young SHR and WKY Rats

Age-Related Alterations in Endothelial Function of Femoral Artery in Young SHR and WKY Rats

Increased neuroplasticity may protect against cardiovascular disease

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