Distribuição por gênero de ácido úrico sérico e fatores de risco cardiovascular: estudo populacional

Rodrigues, Sérgio Lamêgo; Baldo, Marcelo Perim; Capingana, Pires; Magalhães, Pedro; Dantas, Eduardo Miranda; Molina, María del Carmen Bisi; Salaroli, Luciane Bresciani; Morelato, Renato Lário; Mill, José Geraldo

doi:10.1590/s0066-782x2011005000116

Cited by 47 publications

(18 citation statements)

References 24 publications

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“…On the other hand, metabolic syndrome was positively associated with increasing SUA, regardless of gender. Abdominal obesity and hypertriglyceridemia were the main factors associated with hyperuricemia even in normotensive individuals, and they may add a higher risk for hypertensive individuals [46]. Our data is in agreement with each of these observations, as it shows a simultaneous increase in uric acid, TGs, waist circumference and blood pressure in men relative to women.…”

Section: Discussionsupporting

confidence: 90%

Markers of Increased Cardiovascular Risk in Postmenopausal Women: Focus on Oxidized-LDL and HDL Subpopulations

et al. 2013

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Objective. To evaluate the effect of gender and menopause in cardiovascular risk (CVR) in a healthy population based on both classical and nontraditional markers. Methods. 56 men and 68 women (48 pre- and 20 postmenopause) were enrolled in the study. The following markers were analyzed: blood pressure (BP), body mass index (BMI), waist circumference (WC), glucose, total cholesterol (total-c), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-c), oxidized-LDL (Ox-LDL), HDL-c and subpopulations, paraoxonase-1 activity, hsCRP, uric acid, tumor necrosis factor alpha (TNF-α), adiponectin, vascular endothelial growth factor (VEGF), and intercellular adhesion molecular 1 (ICAM1). Results. Relative to the women, men present significantly increased BMI, WC, BP, glucose, total-c, TGs, LDL-c, Ox-LDL, uric acid, and TNF-α and reduced adiponectin and total and large HDL-c. The protective profile of women is lost after menopause with a significantly increased BMI, WC, BP, glucose, LDL-c, Ox-LDL, hsCRP, and VEGF and decreased total and large HDL-c. Significant correlations were found in women population and in postmenopausal women between Ox-LDL and total, large, and small HDL-c and between TNF-α and total, large, and small HDL-c, LDL-c, and Ox-LDL. Conclusions. Men present higher CVR than women who lost protection after menopause, evidenced by nontraditional markers, including Ox-LDL and HDL subpopulations.

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Section: Discussionsupporting

confidence: 90%

Markers of Increased Cardiovascular Risk in Postmenopausal Women: Focus on Oxidized-LDL and HDL Subpopulations

et al. 2013

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“…Similar results were previously found for uric acid 33,36 and us-CRP 37 in the general population and among workers 38.…”

Section: Discussionsupporting

confidence: 89%

Insulin resistance and associated factors: a cross-sectional study of bank employees

Salaroli

Cattafesta

Molina

et al. 2017

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OBJECTIVE:Insulin resistance is characterized by the failure of target cells to respond to normal levels of circulating insulin, and this condition is related to cardiovascular disease. This study sought to evaluate the prevalence of insulin resistance and its association with markers of metabolic abnormalities and metabolic syndrome in bank employees.METHODS:A cross-sectional study was performed on 498 working men and women aged ≥20 years old. The Homeostasis Model Assessment (HOMA-IR) was used to determine the presence of insulin resistance based on cut-off values of ≤2.71 for normal insulin levels and >2.71 for insulin resistance, as established for the adult Brazilian population.RESULTS:It was observed that the 52 (10.4%) overweight individuals with insulin resistance were 4.97 times (95%CI 1.31-18.83) more likely to have high HOMA-IR values than the normal-weight participants; among those who were obese, the likelihood increased to 17.87 (95%CI 4.36-73.21). Individuals with large waist circumferences were 3.27 times (95%CI 1.03-10.38) more likely to develop insulin resistance than those who were within normal parameters. The HOMA-IR values differed between subjects with and without metabolic syndrome, with values of 2.83±2.5 and 1.10±0.81 (p=0.001), respectively. The levels of insulin, ultrasensitive C-reactive protein and uric acid were also associated with insulin resistance.CONCLUSION:The prevalence of insulin resistance among bank employees is high, and insulin resistance is associated with and serves as a marker of metabolic syndrome. Cardiovascular disease and metabolic syndrome-associated metabolic abnormalities were observed, and insulin resistance may be a risk factor in this group of professionals.

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“…Hyperuricemia results from interaction of several risk factors such as nutrition, social-economic status, gender, age, genetic and environment, making its prevalence variable in different populations and areas. In the present study, which included a healthy, young and well-educated population, the prevalence of hyperuricemia was extremely low, affecting only 4.2% of the subjects, in contrast to 13.2% reported by Rodrigues et al in a Brazilian population (37). The prevalence is higher in developed countries perhaps as a consequence of diet, sedentary lifestyle and an increase in obesity and hypertension, reaching 21.4% among US adults (38).…”

Section: Discussioncontrasting

confidence: 78%

Relationship between uric acid levels and risk of chronic kidney disease in a retrospective cohort of Brazilian workers

Chini

Assis

Lugon

2017

Braz J Med Biol Res

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Uric acid (UA) levels are increased in patients with kidney dysfunction. We analyzed the association between asymptomatic hyperuricemia and new-onset chronic kidney disease (CKD). A retrospective cohort study was designed to collect data from employees of an energy generation and distribution company in the city of Rio de Janeiro, Brazil, who had undergone the company’s annual medical checkup from 2008 to 2014. People with ≤2 years of follow-up, with baseline estimated glomerular filtration rate (eGFR) <60 mL·min-1·(1.73 m2)-1 or with incomplete data were excluded. The endpoint was defined as eGFR <60 mL·min-1·(1.73 m2)-1 estimated through the chronic kidney disease epidemiology collaboration equation (CKD-EPI). The study included 1094 participants. The mean follow-up period was 5.05±1.05 years and 44 participants exhibited new-onset CKD. The prevalence of hyperuricemia was 4.2%. There was a significant inverse correlation between baseline serum levels of UA and baseline eGFR (R=-0.21, P<0.001). Female gender (OR=4.00; 95%CI=1.92-8.29, P<0.001) and age (OR=1.06; 95%CI=1.02-1.11, P=0.004) but not UA levels (OR=1.12; 95%CI=0.83-1.50; P=0.465) were associated with new-onset CKD. Diabetes mellitus and body mass index were independent factors for fast progression (OR=2.17; 95%CI=1.24-3.80, P=0.007 and OR=1.04; 95%CI=1.01-1.07; P=0.020). These results did not support UA as an independent predictor for CKD progression in the studied population.

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Distribuição por gênero de ácido úrico sérico e fatores de risco cardiovascular: estudo populacional

Abstract: Background: There is no data concerning the epidemiology of hyperuricemia in Brazilian population-based studies.

Cited by 47 publications

References 24 publications

Markers of Increased Cardiovascular Risk in Postmenopausal Women: Focus on Oxidized-LDL and HDL Subpopulations

Markers of Increased Cardiovascular Risk in Postmenopausal Women: Focus on Oxidized-LDL and HDL Subpopulations

Insulin resistance and associated factors: a cross-sectional study of bank employees

Relationship between uric acid levels and risk of chronic kidney disease in a retrospective cohort of Brazilian workers

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