Fatores associados ao aumento no índice de incremento de pressão radial em indivíduos hipertensos

Vaz-de-Melo, Renan Oliveira; Pimenta, Adriana Giubilei; Júnior, Luiz Tadeu Giollo; Martinelli, Débora Dada; Sacomani, Carolina Neves Cosenso; Cipullo, José Paulo; Gomes, Marco Antônio Mota; Júnior, Heitor Moreno; Vilela-Martin, José Fernando

doi:10.1590/s0066-782x2011005000087

Cited by 6 publications

(1 citation statement)

References 40 publications

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“…This increase in the CBP caused by the reflection of waves is known as the augmentation index (AIx). Hence, the AIx is an alternative index derived from the analysis of the central aortic pressure curve and quantifies the effect of reflected waves [ 45 – 47 ]. It has the advantage of taking into account the time of anterograde and retrograde waves, which are the main determinants of CBP.…”

Section: Introductionmentioning

confidence: 99%

Effects of transcutaneous electrical nerve stimulation (TENS) on arterial stiffness and blood pressure in resistant hypertensive individuals: study protocol for a randomized controlled trial

Vilela-Martin

Giollo-Júnior

Chiappa

et al. 2016

Trials

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BackgroundResistant hypertension (RH) treatment requires an adequate and intense therapeutic approach. However, the results are not always satisfactory despite intensive treatment. Of the different pathophysiological mechanisms involved in the pathogenesis of RH, sympathetic overstimulation and therapies that block the sympathetic system have been widely studied. These approaches, however, are invasive and expensive. Another possible approach is by transcutaneous electrical nerve stimulation (TENS), a noninvasive method that modulates activity by using low-frequency transcutaneous electrical stimulation to inhibit primary afferent pathways. Thus, the current study will evaluate the effect of applying TENS in the cervicothoracic region of subjects with RH and will seek to develop a new low-cost and readily available therapy to treat this group of hypertensive individuals.Methods/designThis is a randomized, single blind (subject), parallel-assignment study controlled with a sham group and including participants aged 40 to 70 years with resistant hypertension. The trial has two arms: the treatment and control (sham group). The treatment group will be submitted to the stimulation procedure (TENS). The sham group will not be submitted to stimulation. The primary outcomes will be a reduction in the peripheral blood pressure and adverse events. The secondary outcomes will be a reduction the central blood pressure. The study will last 30 days. The sample size was calculated assuming an alpha error of 5 % to reject the null hypothesis with a statistical power of 80 %, thereby resulting in 28 participants per group (intervention versus sham).DiscussionIn recent decades, RH has become very common and costly. Adequate control requires several drugs, and in many cases, treatment is not successful. Sympathetic nervous system inhibition by renal denervation and central inhibition have significant effects in reducing BP; however, these treatments are costly and invasive. Another type of sympathetic nervous system inhibition can also be noninvasively achieved by electric current. Therefore, the application of TENS may be a new therapeutic option for treating resistant hypertensive individuals.Trial RegistrationClinical Trials NCT02365974Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-016-1302-8) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Effects of transcutaneous electrical nerve stimulation (TENS) on arterial stiffness and blood pressure in resistant hypertensive individuals: study protocol for a randomized controlled trial

Vilela-Martin

Giollo-Júnior

Chiappa

et al. 2016

Trials

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Colectomy influences the radial pulse parameters of traditional Chinese medicine pulse diagnosis in patients with colorectal cancer

Chuang

Chang

et al. 2020

European Journal of Integrative Medicine

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Radial augmentation index may be an effective predictor of vascular calcification in patients on peritoneal dialysis

Yang

Cui

et al. 2020

Renal Failure

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Vascular calcification (VC) is an important promoter of cardiovascular disease (CVD) in patients undergoing peritoneal dialysis (PD). Several indices can be used to evaluate VC, including the abdominal aortic calcification index (AACI) and carotid artery intima-media thickness (IMT); however, simpler and lesser expensive predictors, such as the radial augmentation index (RAI), should be investigated. A total of 101 patients undergoing PD were recruited to measure RAI, AACI, and carotid artery IMT and perform echocardiography. Fifty healthy controls (HCs) were recruited to undergo RAI measurement. RAI in patients undergoing PD was significantly higher than the RAI in HCs (86.25%±8.39% vs. 76.05%±9.81%, p < 0.05). Patients undergoing PD and who suffer with diabetic mellitus, hypertension, and CVD had more severe VC than those without the abovementioned diseases. In patients with PD, RAI was positively correlated with AACI (r ¼ 0.671, p < 0.05) and carotid artery IMT (r ¼ 0.596, p < 0.05). RAI was positively correlated with left ventricular enddiastolic dimensions (LVDd; r ¼ 0.678, p < 0.05), left ventricular mass index (r ¼ 0.595, p < 0.05), and negatively correlated with early-diastolic mitral inflow velocity/late-diastolic mitral inflow velocity (r ¼ À0.342, p < 0.05) and left ventricular ejection fraction (r¼ À0.497, p < 0.05). Multiple linear regression analysis showed that RAI was associated with AACI, LVDd, age, and serum phosphate (p < 0.05). RAI might be an effective predictor of VC and cardiac structural/functional abnormalities in patients undergoing PD.

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Fatores associados ao aumento no índice de incremento de pressão radial em indivíduos hipertensos

Abstract: Background: Arterial stiffness is a variable predictor of morbidity and mortality and a possible marker of vascular injury. Its non-invasive assessment by radial tonometry and analysis of the augmentation index (r-AI) allows identifying patients exposed to higher cardiovascular risk.

Cited by 6 publications

References 40 publications

Effects of transcutaneous electrical nerve stimulation (TENS) on arterial stiffness and blood pressure in resistant hypertensive individuals: study protocol for a randomized controlled trial

Effects of transcutaneous electrical nerve stimulation (TENS) on arterial stiffness and blood pressure in resistant hypertensive individuals: study protocol for a randomized controlled trial

Colectomy influences the radial pulse parameters of traditional Chinese medicine pulse diagnosis in patients with colorectal cancer

Radial augmentation index may be an effective predictor of vascular calcification in patients on peritoneal dialysis

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