BackgroundFunctional assessment of coronary artery obstruction is used in cardiology
practice to correlate anatomic obstructions with flow decrease. Among such
assessments, the study of the coronary fractional flow reserve (FFR) has
become the most widely used.ObjectiveTo evaluate the correlation between FFR and findings of ischemia obtained by
noninvasive methods including stress echocardiography and nuclear medicine
and the presence of critical coronary artery obstruction.MethodsRetrospective study of cases treated with systematized and standardized
procedures for coronary disease between March 2011 and August 2014. We
included 96 patients with 107 critical coronary obstructions (> 50% in
the coronary trunk and/or ≥ 70% in other segments) estimated by
quantitative coronary angiography (QCA) and intracoronary ultrasound (ICUS).
All cases presented ischemia in one of the noninvasive studies.ResultsAll 96 patients presented ischemia (100%) in one of the functional tests. On
FFR study with adenosine 140 g/kg/min, 52% of the cases had values ≤
0.80. On correlation analysis for FFR ≤ 0.80, the evaluation of
sensitivity, specificity, positive and negative predictive values, accuracy,
and ROC curve in relation to the stenosis degree and length, and presence of
ischemia, no significant values or strong correlation were observed.ConclusionCoronary FFR using a cut-off value of 0.80 showed no correlation with
noninvasive ischemia tests in patients with severe coronary artery
obstructions on QCA and ICUS.