Treinamento em natação atenua a disfução contrátil de cardiomiócitos de ratos diabéticos

Silva, Márcia Ferreira da; Pelúzio, Maria do Carmo Gouveia; Amorim, Paulo; Lavorato, Victor Neiva; Santos, Natália Pereira do; Bozi, Luíz Henrique Marchesi; Penitente, Arlete Rita; Falkoski, Daniel Luciano; Berfort, Felipe Gomes; Natali, Antônio José

doi:10.1590/s0066-782x2011005000055

Cited by 13 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We can therefore conclude that exercise attenuated lung congestion, left atrium dilation, and systolic and diastolic myocardial dysfunction in diabetic rats. Physical exercise has been previously shown to improve cardiac function in diabetic rats and attenuate diabetes-induced impaired fractional shortening, contraction velocity, and relaxation time in isolated cardiomyocytes [ 55 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats

Gimenes

Rosa

et al. 2015

Journal of Diabetes Research

View full text Add to dashboard Cite

We evaluated the effects of a low intensity aerobic exercise protocol on cardiac remodeling and myocardial function in diabetic rats. Wistar rats were assigned into four groups: sedentary control (C-Sed), exercised control (C-Ex), sedentary diabetes (DM-Sed), and exercised diabetes (DM-Ex). Diabetes was induced by intraperitoneal injection of streptozotocin. Rats exercised for 9 weeks in treadmill at 11 m/min, 18 min/day. Myocardial function was evaluated in left ventricular (LV) papillary muscles and oxidative stress in LV tissue. Statistical analysis was given by ANOVA or Kruskal-Wallis. Echocardiogram showed diabetic groups with higher LV diastolic diameter-to-body weight ratio and lower posterior wall shortening velocity than controls. Left atrium diameter was lower in DM-Ex than DM-Sed (C-Sed: 5.73 ± 0.49; C-Ex: 5.67 ± 0.53; DM-Sed: 6.41 ± 0.54; DM-Ex: 5.81 ± 0.50 mm; P < 0.05 DM-Sed vs C-Sed and DM-Ex). Papillary muscle function was depressed in DM-Sed compared to C-Sed. Exercise attenuated this change in DM-Ex. Lipid hydroperoxide concentration was higher in DM-Sed than C-Sed and DM-Ex. Catalase and superoxide dismutase activities were lower in diabetics than controls and higher in DM-Ex than DM-Sed. Glutathione peroxidase activity was lower in DM-Sed than C-Sed and DM-Ex. Conclusion. Low intensity exercise attenuates left atrium dilation and myocardial oxidative stress and dysfunction in type 1 diabetic rats.

show abstract

Section: Discussionmentioning

confidence: 99%

Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats

Gimenes

Rosa

et al. 2015

Journal of Diabetes Research

View full text Add to dashboard Cite

show abstract

“…The cell contraction was measured by the technique of changing the length of cardiomyocytes using an edge detection system mounted on an inverted microscope (Ionoptix, USA) as described previously 14,15 . The cardiomyocytes were placed in an experimental chamber with glass base and bathed in buffer containing the following composition (in mM): 136.9 NaCl; 5.4 KCl; NaH2PO4 0.37; 0.57 MgCl2; 5 Hepes; 5.6 Glucose; 1.0 CaCl2 (pH 7.4).…”

Section: Cell Contractionmentioning

confidence: 99%

Morfologia e contratilidade em cardiomiócitos de ratos com baixo desempenho para o exercício físico

Júnior¹,

Natali²,

Carneiro‐Júnior³

et al. 2012

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

Chylothorax and Other Pleural Effusions in Neonates

Azizkhan¹

2017

Pediatric Surgery

View full text Add to dashboard Cite

Treinamento em natação atenua a disfução contrátil de cardiomiócitos de ratos diabéticos

Abstract: Background: Experimental diabetes promotes contractile dysfunction in cardiomyocytes, but the effects of swimming in this disorder are not known.

Cited by 13 publications

References 37 publications

Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats

Low Intensity Physical Exercise Attenuates Cardiac Remodeling and Myocardial Oxidative Stress and Dysfunction in Diabetic Rats

Morfologia e contratilidade em cardiomiócitos de ratos com baixo desempenho para o exercício físico

Chylothorax and Other Pleural Effusions in Neonates

Contact Info

Product

Resources

About