Associação entre ácido úrico e variáveis de risco cardiovascular em uma população não hospitalar

Barbosa, Monica Cristina Campos; Brandão, Andréa Araújo; Pozzan, Roberto; Magalhães, Maria Eliane Campos; Campana, Érika Maria Gonçalves; Fonseca, Flavia Lopes; Pizzi, Oswaldo Luiz; Freitas, Elizabete Viana de; Brandão, Ayrton Pires

doi:10.1590/s0066-782x2011005000011

Cited by 11 publications

(12 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study showed an inverse association between HDL-c and UA levels. The same was observed by Barbosa et al ( 8 ) in a not hospitalized population. The relation between low HDL and high UA seems to be mediated by insulin resistance; that was confirmed by de Oliveira et al, who observed that the correlation between HDL and UA is lost after statistical adjustments by MS components.…”

Section: Discussionsupporting

confidence: 88%

“…These results were described in other studies, such as that by Barbosa et al . ( 8 ) , with a sample of 756 subjects, in which a direct association between blood pressure and UA was observed. The reduced excretion of UA is reported in patients with MS, and it seems to reflect changes in renal excretion of renal UA, secondary to the increased resorption of sodium by proximal tubules, mediated by hyperinsulinemia.…”

Section: Discussionmentioning

confidence: 99%

“…The reduced excretion of UA is reported in patients with MS, and it seems to reflect changes in renal excretion of renal UA, secondary to the increased resorption of sodium by proximal tubules, mediated by hyperinsulinemia. ( 8 ) Another plausible mechanism refers to the action of UA by inhibiting the bioavailability of nitric oxide, a powerful vasodilator. ( 30 )…”

Section: Discussionmentioning

confidence: 99%

“…However, a rational physiological base is needed to explain the relation between UA and cardiovascular risk and the development of appropriate therapies to treat changes in UA levels, since these potential associations still remain unproven. ( 8 )…”

Section: Introductionmentioning

confidence: 99%

“…Including UA as a variable to stratify cardiovascular risk may be interesting, because it is low-cost, easily-performed test, which is useful in clinical practice, especially for MS patients. ( 8 ) However, few studies have investigated the predictive role of UA levels, ( 6 , 8 - 10 ) and studies that investigate the relation between UA and MS criteria in patients previously detected with cardiovascular risk are still scarce.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Relation between uric acid and metabolic syndrome in subjects with cardiometabolic risk

Silva

Carraro

Bressan

et al. 2015

Einstein (São Paulo)

View full text Add to dashboard Cite

Objective To identify possible relations between serum uric acid levels and metabolic syndrome and its components in a population with cardiometabolic risk.Methods This cross-sectional study included 80 subjects (46 women), with mean age of 48±16 years, seen at the Cardiovascular Health Program.Results The prevalence of hyperuricemia and metabolic syndrome was 6.3% and 47.1%, respectively. Uric acid level was significantly higher in individuals with metabolic syndrome (5.1±1.6mg/dL), as compared to those with no syndrome or with pre-syndrome (3.9±1.2 and 4.1±1.3mg/dL, respectively; p<0.05). The uric acid levels were significantly higher in men presenting abdominal obesity, and among women with abdominal obesity, lower HDL-c levels and higher blood pressure (p<0.05).Conclusion Uric acid concentrations were positively related to the occurrence of metabolic syndrome and its components, and there were differences between genders. Our results indicate serum uric acid as a potential biomarker for patients with cardiometabolic risk.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%