Correlação da função diastólica com a capacidade máxima de exercício ao teste ergométrico

Otto, Maria Estefânia Bosco; Pereira, Márcio Mendes; Beck, Adenalva Lima de Souza; Milani, Maurício

doi:10.1590/s0066-782x2011005000004

Cited by 6 publications

(3 citation statements)

References 32 publications

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“…Consequently, filling pressure increases and maximum capacity decreases; thus, as diastolic dysfunction progresses, the lower will become exercise capacity. 48,49 Early-life stress is also a relevant factor involved in metabolic programming. 7 Despite this, biometric, nutritional, and biochemical outcomes here described are similar to those observed in studies using pharmacological and non-pharmacological models of early weaning that avoid emotional stress.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, hypertension is often associated with left ventricular hypertrophy and heart failure with preserved ejection fraction, that impair exercise tolerance, outcomes described in this study. 48,49,53,54 Literature report that adaptation mechanisms may be different between sexes in early weaning models. 7 Nevertheless, our main objective was to describe outcomes in male rats submitted to an early weaning model encompassing an emotional stress, as widely performed with pharmacological and non-pharmacological models.…”

Section: Discussionmentioning

confidence: 99%

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Biometric, nutritional, biochemical, and cardiovascular outcomes in male rats submitted to an experimental model of early weaning that mimics mother abandoning

Barros

Alvim-Silva

Souza

et al. 2020

J Dev Orig Health Dis

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Literature describes breast milk as the best food for the newborn, recommending exclusive breastfeeding for up to 6 months of age. However, it is not available for more than 40% of children worldwide. Pharmacological and non-pharmacological models of 3-day early weaning were developed in rodents to investigate later outcomes related solely to this nutritional insult. Thus, the present work aimed to describe biometric, nutritional, biochemical, and cardiovascular outcomes in adult male rats submitted to 3-day early weaning achieved by maternal deprivation. This experimental model comprises not only nutritional insult but also emotional stress, simulating mother abandoning. Male offspring were physically separated from their mothers at 21st (control) or 18th (early weaning) postnatal day, receiving water/food ad libitum. Analysis performed at postnatal days 30, 90, 150, and 365 encompassed body mass and food intake monitoring and serum biochemistry determination. Further assessments included hemodynamic, echocardiographic, and cardiorespiratory evaluation. Early-weaned males presented higher body weight when compared to control as well as dyslipidemia, higher blood pressure, diastolic dysfunction, and cardiac hypertrophy in adult life. Animals early deprived of their mothers have also presented a worse performance on the maximal effort ergometer test. This work shows that 3-day early maternal deprivation favors the development of cardiovascular disease in male rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Biometric, nutritional, biochemical, and cardiovascular outcomes in male rats submitted to an experimental model of early weaning that mimics mother abandoning

Barros

Alvim-Silva

Souza

et al. 2020

J Dev Orig Health Dis

View full text Add to dashboard Cite

show abstract

“…Several studies that sought to compare functional capacity with ventricular filling patterns in patients with HFPEF correlating them to finding of healthy individuals converged their theoretical reference in the pursuit of understanding exercise intolerance 32 - 35 . In the present study, the population samples show important differences in CPET variables and LV filling parameters as assessed by Echo, and this requires considerations on the different mechanisms of exercise intolerance in patients with HFPEF.…”

Section: Discussionmentioning

confidence: 99%

Ergospirometry and Echocardiography in Early Stage of Heart Failure with Preserved Ejection Fraction and in Healthy Individuals

Garcia¹,

Menezes²,

Stefani³

et al. 2015

Arquivos Brasileiros De Cardiologia

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BackgroundHeart failure with preserved ejection fraction is a syndrome characterized by changes in diastolic function; it is more prevalent among the elderly, women, and individuals with systemic hypertension (SH) and diabetes mellitus. However, in its early stages, there are no signs of congestion and it is identified in tests by adverse remodeling, decreased exercise capacity and diastolic dysfunction.ObjectiveTo compare doppler, echocardiographic (Echo), and cardiopulmonary exercise test (CPET) variables - ergospirometry variables - between two population samples: one of individuals in the early stage of this syndrome, and the other of healthy individuals.MethodsTwenty eight outpatients diagnosed with heart failure according to Framingham’s criteria, ejection fraction > 50% and diastolic dysfunction according to the european society of cardiology (ESC), and 24 healthy individuals underwent Echo and CPET.ResultsThe group of patients showed indexed atrial volume and left ventricular mass as well as E/E’ and ILAV/A´ ratios significantly higher, in addition to a significant reduction in peak oxygen consumption and increased VE/VCO2 slope, even having similar left ventricular sizes in comparison to those of the sample of healthy individuals.ConclusionThere are significant differences between the structural and functional variables analyzed by Echo and CPET when comparing two population samples: one of patients in the early stage of heart failure with ejection fraction greater than or equal to 50% and another of healthy individuals.

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Diastolic Stress Test for the Evaluation of Exertional Dyspnea

Kane

2012

Curr Cardiol Rep

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Correlação da função diastólica com a capacidade máxima de exercício ao teste ergométrico

Abstract: Background: Increased pulmonary capillary pressure (PCP) is one of the mechanisms of exercise intolerance. Assessment of the diastolic function by echocardiography (ECHO) enables estimation of PCP.

Cited by 6 publications

References 32 publications

Biometric, nutritional, biochemical, and cardiovascular outcomes in male rats submitted to an experimental model of early weaning that mimics mother abandoning

Biometric, nutritional, biochemical, and cardiovascular outcomes in male rats submitted to an experimental model of early weaning that mimics mother abandoning

Ergospirometry and Echocardiography in Early Stage of Heart Failure with Preserved Ejection Fraction and in Healthy Individuals

Diastolic Stress Test for the Evaluation of Exertional Dyspnea

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