Síndrome de Heyde: relato de caso e revisão da literatura

Figuinha, Fernando Côrtes Remisio; Spina, Guilherme Sobreira; Tarasoutchi, Flávio

doi:10.1590/s0066-782x2011000300017

Cited by 14 publications

(11 citation statements)

References 7 publications

(4 reference statements)

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“…The clinical presentation with digestive hemorrhage is related to the type 2A acquired von Willebrand syndrome that occurs in these patients [5] . The passage of von Willebrand factor (vWF) by valve stenosis causes the proteolysis of its high-molecular-weight multimers by a proteinase that acts preferentially under high shear stress situations, called ADAMTS 13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) [2] .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that there is an inverse relationship between the mean aortic transvalvar gradient and the percentage of high-molecular-weight multimers of vWF in the circulation [4] . The vWF is secreted by the endothelium and its multimers are important for adequate platelet-mediated hemostasis when they bind to platelet glycoprotein Ib [5] .…”

Section: Discussionmentioning

confidence: 99%

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Heyde Syndrome Treated by Conventional Aortic Valve Replacement

Garcia¹,

Garzesi²,

Tripoli³

et al. 2019

Braz J Cardiovasc Surg

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Heyde syndrome manifests as aortic stenosis associated with gastrointestinal bleeding. We describe the case of a 64-year-old man who came to the emergency room due to acute heart failure and intermittent gastrointestinal bleeding. Treatment involves initial correction of anemia and heart failure followed by aortic valve replacement. The prosthesis used depends on the characteristics of each patient and valve replacement allows the resolution of bleeding in most cases. Gastrointestinal bleeding in patients with aortic stenosis is associated with severity of the valve obstruction. A mechanical prosthesis was used with no recurrent bleeding even with the need for lifelong anticoagulation therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Heyde Syndrome Treated by Conventional Aortic Valve Replacement

Garcia¹,

Garzesi²,

Tripoli³

et al. 2019

Braz J Cardiovasc Surg

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“…3-5,7,8 VWF is secreted by blood endothelial cells, contributing to the formation of platelet thrombi and acting as a mediator of platelet adhesion in the vascular lesion site. 5 …”

Section: Discussionmentioning

confidence: 99%

“…Von Willebrand Factor (vWF) is a multimeric protein, secreted by endothelial cells and platelets. 5 It promotes adherence of platelets to vascular lesion sites through glycoprotein Ib-vWF interactions. A change in the shape of vWF occurs in AoS, making such protein more susceptible to proteolytic cleavage.…”

Section: Introductionmentioning

confidence: 99%

Heyde's Syndrome and Transcatheter Aortic Valve Implantation

Balbo¹,

Seabra²,

Galoro³

et al. 2016

Arquivos Brasileiros De Cardiologia

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“…Unremarkable results of preoperative coagulation investigations constituted our initial concern; however, hematological abnormalities are related to severity and may lack in 8-33% of cases 3,8,12 . Moreover, some case studies about Heyde syndrome have been published without confirmation by the gold standard gel electrophoresis that the heaviest vWF multimers were decreased 2,5,12,14 . This may be due to unavailability of the required high cost assays in developing regions, and vWS-2A coagulopathy may be absent in patients with aortic gradients below 50 mmHg 6,12 .…”

Section: Discussionmentioning

confidence: 99%

Heyde syndrome in a 71-year-old man who underwent chest radiotherapy at young age

Santos

Santos²,

Modesto³

et al. 2013

Anales Sis San Navarra

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We report the case of a 71-year-old man with diagnosis of aortic valve stenosis for ten years, who came to hospital because of breathlessness during the previous two months and recent low intestinal hemorrhage. On admission, laboratory tests and upper gastrointestinal endoscopy and colonoscopy revealed anemia and bleeding cecal angiodysplasia. The echocardiography study showed a severe aortic stenosis. Classical Heyde syndrome is described as the association of aortic stenosis, bleeding gastrointestinal angiodysplasia and secondary anemia. The antecedent of mediastinal radiotherapy for treatment of Hodgkin's disease during his youth, and eventual late cardiac adverse effects that may include aortic or mitral valve disturbances are highlighted. Electrocoagulation with argonium was performed on the sites of active bleeding during the colonoscopy. In sequence, surgical replacement by bioprothesis was done on the aortic valve. The patient remains asymptomatic, under long-term outpatient surveillance, with normal control evaluations. The aim of this case study is to emphasize difficulties related to diagnosis, and to highlight the role of endoscopy and imaging studies to confirm a hypothesis of this underestimated condition.

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Síndrome de Heyde: relato de caso e revisão da literatura

Cited by 14 publications

References 7 publications

Heyde Syndrome Treated by Conventional Aortic Valve Replacement

Heyde Syndrome Treated by Conventional Aortic Valve Replacement

Heyde's Syndrome and Transcatheter Aortic Valve Implantation

Heyde syndrome in a 71-year-old man who underwent chest radiotherapy at young age

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