Influência da aterosclerose subclínica na função diastólica em indivíduos sem doença cardiovascular

Abstract

Background: It is plausible that subclinical atherosclerosis alters coronary reserve and impairs diastolic function of the left ventricle. However, the relationship between subclinical stages of atherosclerosis and diastolic function has not been established in subjects free of cardiovascular disease.

Correlation between diastolic dysfunction and coronary artery disease on coronary computed tomography angiography

“…However, they used carotid intima-media thickness as a surrogate for subclinical atherosclerosis instead of CACS. [ 3 ] In another study, Eleid et al . did not find consistent relation between coronary artery plaque burden as assessed by CACS and echocardiographic grade of LV DD in the population of asymptomatic adults with normal LV ejection fraction and negative cardiac stress test results.…”

“…[ 1 ] During this period, nonobstructive atherosclerotic plaques may not cause ischemia,[ 2 ] but promote functional changes in vascular tone, related to vasoactive mediators release and impaired production of nitric oxide by a dysfunctional endothelium. [ 3 4 ] Computed tomographic coronary artery calcium score (CACS) is a surrogate for coronary atherosclerosis burden and independently predicts future cardiovascular (CV) risk. [ 5 6 7 ]…”