Aterosclerose experimental em coelhos

Dornas, Waleska Claudia Amaral; Oliveira, Tânia Toledo de; Augusto, Luís; Nagem, Tânus Jorge

doi:10.1590/s0066-782x2010001200020

Cited by 31 publications

(24 citation statements)

References 54 publications

(26 reference statements)

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“…), over 6 weeks 4, 15 . Similar to atherosclerotic plaque formation in the aorta, the periodontal disease closely resembles that in humans macroscopically and histologically 14 . In a previous study with simultaneous induction of periodontitis and atherosclerosis in New Zealand White (NZW) rabbits over 13 weeks, rabbits with experimentally induced periodontitis had more extensive accumulation of aortic lipids than did periodontitis-free animals 16 .…”

Section: Introductionmentioning

confidence: 59%

“…In rabbits, lesion morphology is altered by the percentage of cholesterol added to the diet and the duration of the diet. Short duration and a high percentage of cholesterol of more than 2% cause hypercholesterolemia, and atherogenic lesions rich in foam cells originating from macrophages 14 . In contrast, a diet with a low cholesterol content and long duration causes atherosclerotic lesions, which are rich in smooth muscle cells and contain cholesterol deposits leading to lesions more similar to those of humans 14 .…”

Section: Discussionmentioning

confidence: 99%

“…Rabbits provide a range of plaque stages that more closely resemble those in humans without genetic modification of the animal, and the plaque development can be modulated by diet 13, 14 . The rabbit is also a unique and valuable model for experimental periodontitis, which is induced by topical application of a human periodontal pathogen, Porphyromonas gingivalis (P.…”

Section: Introductionmentioning

confidence: 99%

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Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis

Hastürk

Abdallah

Kantarcı

et al. 2015

ATVB

175

155

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Objective Epidemiological and recent clinical studies implicate periodontitis as an independent risk factor for cardiovascular disease. Previously, we demonstrated that rabbits with experimental periodontitis and cholesterol diet exhibit more aortic plaque compared to diet alone. We also showed that a proresolution mediator, Resolvin E1 (RvE1), reverses the experimental periodontitis. Here, we determined whether oral/topical application of RvE1 attenuates aortic atherosclerosis induced by both diet and periodontal inflammation. Approach and Results Thirty-nine rabbits on a 13-week regimen of 0.5% cholesterol diet were included. Periodontitis was induced by P. gingivalis in 24 rabbits and 15 rabbits were placed in no-periodontitis groups. Interventions were no-treatment, vehicle, and RvE1 treatment (4μg/site or 0.4 μg/site) topically applied 3-times/ week. At 13 weeks, both periodontitis and atherosclerosis were quantified. Atherosclerotic plaques were assessed by Sudan IV staining, histology and ex vivo MRI. Serum levels of C-reactive protein (CRP) were evaluated as a measure of systemic inflammation.RvE1, used as an oral/topical agent, significantly diminished atherogenesis and prevented periodontitis (p<0.05). In the absence of periodontal inflammation, oral/topical application of RvE1 resulted in significantly less arterial plaque, a lower intima/media ratio, and decreased inflammatory cell infiltration compared to no-treatment (p<0.001). Local oral RvE1 application significantly reduced systemic levels of CRP (p<0.05). Conclusions The results suggest that oral/topical RvE1 attenuates enhanced atherogenesis induced by periodontitis and prevents vascular inflammation and atherogenesis in the absence of periodontitis. The inhibition of vascular inflammation with endogenous mediators of resolution of inflammation provides a novel approach in the prevention of atherogenic events.

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Section: Introductionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis

Hastürk

Abdallah

Kantarcı

et al. 2015

ATVB

175

155

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“…A importância de distúrbios de lipoproteínas plasmáticas e anormalidades no metabolismo lipídico caracterizadas por hiperlipidemia e/ou hipercolesterolemia como fator etiológico no desenvolvimento de doenças cardíacas coronarianas e aterosclerose potencial são, atualmente, cada vez mais apoiadas por considerável número de estudos populacionais e epidemiológicos (DORNAS et al, 2010).…”

Section: Médias Dos Níveis De Colesterolunclassified

“…Estes compostos são universalmente encontrados em uma grande variedade de frutas, vegetais e algumas bebidas, incluindo chá e vinho, e por isso, são largamente consumidos na dieta humana (DORNAS et al, 2007).…”

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Análise comparativa do efeito redutor de colesterol do extrato de semente e casca de uva em ratos Wistar

Oliveira

Almeida²,

Sé³

et al. 2016

Rev Bra de Edu e Saude

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Resumo: Os flavonóides são compostos fenólicos presentes na maioria das plantas. Têm um importante papel na prevenção e tratamento da aterosclerose, pois, atuam como agentes antiaterogênicos e hipocolesterolêmicos. Objetivouse nessa pesquisa estudar o efeito redutor de colesterol do extrato de semente e de casca de uva (Vitis vinifera) em ratos Wistar submetidos a uma dieta hipercalórica (ração acrescida de 10% de óleo vegetal) no período de 20 semanas, a partir da 4ª semana de vida. A amostra, composta por 30 espécimes e distribuída entre o Grupo Controle -A (com apenas dieta hipercalórica, n=10) o Grupo Experimental Casca de Uva -B (dieta hipercalórica + extrato de casca de uva, n=10) e Grupo Experimental Semente de Uva -C (dieta hipercalórica + de extrato de semente de uva, n=10). Os resultados mostraram em média, uma redução dos níveis séricos de colesterol total de 14% e de 17,65% em relação ao grupo controle, respectivamente para os animais com dieta a base de casca e de semente de uva. Não houve diferença estatisticamente significativa na redução dos valores de colesterol entre os animais dos dois grupos, não sendo possível assim determinar qual componente da uva representa a melhor alternativa na prevenção e controle da hipercolesterolemia. Palavras-chave: Dieta Hiperlipídica; Flavonóides; HipercolesterolemiaAbstract: Flavonoids are phenolic compounds present in most plants. They play an important role in the prevention and treatment of atherosclerosis, as hypocholesterolemic and antiatherogenic act as agents. This research aimed to study and compare the cholesterol-lowering effect of seed extract and grape skin (Vitis vinifera) in rats subjected to a high calorie diet (increased ration of 10% vegetable oil) in the 20-week period, from the 4th week of life. The sample consisted of 30 specimens and distributed between the Control -A (with only high calorie diet, n = 10) Experimental Group Grape Bark -B (high calorie diet + grape skin extract, n = 10) and experimental group Grape Seed -C (calorie diet + grape seed extract, n = 10). The results showed on average a reduction in serum total cholesterol by 14% and 17.65% in the control group, respectively, for the animals with diet based on bark and grape seed. There was no statistically significant difference in reducing cholesterol levels in the animals of both groups, so it is not possible to determine which grape component represents the best alternative in the prevention and control of hypercholesterolemia.

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Hypertriglyceridemia Acute Pancreatitis: Animal Experiment Research

Wang

et al. 2021

Dig Dis Sci

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Aterosclerose experimental em coelhos

Cited by 31 publications

References 54 publications

Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis

Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis

Análise comparativa do efeito redutor de colesterol do extrato de semente e casca de uva em ratos Wistar

Hypertriglyceridemia Acute Pancreatitis: Animal Experiment Research

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