Uso da tomografia de coerência ótica intracoronariana para caracterização precisa da aterosclerose

Abstract

Optical coherence tomography (OCT) is a novel imaging technology based on low-coherence interferometry that uses scattering of near-infrared light as a signal source to provide vascular cross-sectional imaging with definition far superior to any other available modality. With spatial resolution of up to 10 microm, OCT provides 20-fold higher resolution than intravascular ultrasound (IVUS), currently the most used modality for intra-coronary imaging. OCT has the capacity to provide invaluable insight into the various phases of atherosclerotic disease and vascular response to therapeutics. Studies have shown the ability of OCT to detect arterial structures and assist in the determination of different histological constituents. Its capacity to distinguish different grades of atherosclerotic changes and the various types of plaques, as compared to histology, has recently been demonstrated with acceptable intra-observer and inter-observer correlations for these findings. OCT provides unrivaled real-time in vivo endovascular resolution, which has been exploited to assess the vascular structures and response to device deployment. While depth remains a limitation for OCT plaque characterization beyond 2-mm, near-histological resolution can be achieved within the first millimeter of the vessel wall allowing unique assessment of fibrous cap characteristics and thickness. In addition, assessment of neointimal coverage, para-strut tissue patterns and stent apposition can now be scrutinized for individual struts on the micron scale, the so-called strut-level analysis. OCT has propelled intravascular imaging into micron-level in vivo vascular analysis and is expected to soon become a valuable and indispensable tool for the cardiologists on both clinical and research applications.

Intravascular magnetomotive optical coherence tomography of targeted early‐stage atherosclerotic changes in ex vivo hyperlipidemic rabbit aortas

“…Optical coherence tomography (OCT) is a high‐resolution biomedical imaging modality that has become an established standard for clinical ophthalmic imaging and is rapidly developing commercially for clinical applications in cardiology, gastroenterology, oncology, and dermatology . In cardiology, intravascular optical coherence tomography (IV‐OCT) is a promising imaging technique to monitor many cardiovascular interventions and visualize cardiovascular disease .…”

Diagnostic imaging capabilities of the Ocelot -Optical Coherence Tomography System, ex-vivo evaluation and clinical relevance

“…The ability to have accurate and catheter based intravascular imaging provides interventional physicians with invaluable insight into the procedural vascular anatomy [ 1 ]. Luminal angiography has long been the gold standard for visualizing the arterial lumen and is routinely used for arterial reconstruction.…”

Prediction of residual ischemia after coronary stenting by quantitative flow ratio modulated by optical coherence tomography: Where we are now and our future perspectives

“…Optical coherence tomography (OCT) technology was initially applied as the modality in the field of cardiology to reveal the pathological features of coronary artery disease without specimen collection 1 …”

“…"Learning without thought is labor lost; thought without learning is perilous" Confucius Optical coherence tomography (OCT) technology was initially applied as the modality in the field of cardiology to reveal the pathological features of coronary artery disease without specimen collection. 1 Afterward, the realization that it provides accurate and micronlevel anatomical measurement values deepened, 2 thereby developing OCT-guided percutaneous coronary intervention (PCI), which based PCI decisions on OCT.…”