Cardiopatia chagásica crônica na Amazônia: uma etiologia a ser lembrada

Ferreira, João Marcos Bemfica Barbosa; Guerra, Jorge Augusto de Oliveira; Magalhães, Belisa Maria Lopes; Coelho, Leíla I. A. R. C.; Maciel, Marcel Gonçalves; Barbosa, Maria das Graças Vale

doi:10.1590/s0066-782x2009001200028

Cited by 6 publications

(8 citation statements)

References 8 publications

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“…However, in the upper and middle Rio Negro, two cases of severe dilated cardiomyopathy with positive serology for chagasic infection, which resulted in death, were found (27) . Subsequently, new cases with reactive serology for T. cruzi were reported with clinical, electrocardiographic and echocardiographic characteristics suggestive of chronic chagasic cardiomyopathy, manifesting clinically as heart failure, arrhythmogenic syndrome and thromboembolism (28) (29) .…”

Section: Chagas Disease In the State Of Amazonasmentioning

confidence: 99%

Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

Barbosa

Ferreira

Arcanjo

et al. 2015

Rev. Soc. Bras. Med. Trop.

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27www.scielo.br/rsbmt I www.rsbmt.org.br Revista da Sociedade Brasileira de Medicina Tropical 48(Suppl I):27-33, 2015http://dx.doi. org/10.1590/0037-8682-0258-2013 Review Article ABSTRACT Chagas disease (CD) is a parasitic infection that originated in the Americas and is caused by Trypanosoma cruzi.In the last few years, the disease has spread to countries in North America, Asia and Europe due to the migration of Latin Americans. In the Brazilian Amazon, CD has an endemic transmission, especially in the Rio Negro region, where an occupational hazard was described for piaçaveiros (piassaba gatherers). In the State of Amazonas, the fi rst chagasic infection was reported in 1977, and the fi rst acute CD case was recorded in 1980. After initiatives to integrate acute CD diagnostics with the malaria laboratories network, reports of acute CD cases have increased. Most of these cases are associated with oral transmission by the consumption of contaminated food. Chronic cases have also been diagnosed, mostly in the indeterminate form. These cases were detected by serological surveys in cardiologic outpatient clinics and during blood donor screening. Considering that the control mechanisms adopted in Brazil's classic transmission areas are not fully applicable in the Amazon, it is important to understand the disease behavior in this region, both in the acute and chronic cases. Therefore, the pursuit of control measures for the Amazon region should be a priority given that CD represents a challenge to preserving the way of life of the Amazon's inhabitants.

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Section: Chagas Disease In the State Of Amazonasmentioning

confidence: 99%

Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

Barbosa

Ferreira

Arcanjo

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…However, the percentage of neutrophils was increased according to the ELISA data for Chagas disease serology. 17 , several studies were conducted to describe the prevalence 4,7 , acute outbreaks 5,18 and cardiomyopathies 6,14,19 associated with infection by T. cruzi.…”

Section: Seroepidemiological and Immunological Relationshipsmentioning

confidence: 99%

“…Despite the high prevalence, several clinical studies have reported that the acute phase is marked with high morbidity, including some fatal cases of dilated cardiomyopathy 6,19 . It has been reported that Chagas disease in the Middle Negro river has a clinical profile of low morbidity and mortality in the chronic phase 12 .…”

Section: Seroepidemiological and Immunological Relationshipsmentioning

confidence: 99%

“…Several cases of dilated cardiomyopathy were reported in autochthonous patients with chronic chagasic infection from the municipalities of Barcelos and Santa Isabel do Rio Negro 6,26 . Furthermore, it was reported that the frequency of chronic cardiomyopathy associated with Chagas disease in autochthonous individuals from Amazon basin was 8.1% 19 . With this background, it is important to examine whether the exacerbated Th1 immune response against T. cruzi antigens, characterised by high levels of INF-γ secreted from CD3 + CD4 + cells and low levels of IL-10 are demonstrated in individuals with cardiac Chagas disease in the Brazilian Amazon.…”

Section: Seroepidemiological and Immunological Relationshipsmentioning

confidence: 99%

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Piassaba palm extractivism as an associated factor with Chagas disease: seroprevalence and immunological profile in native inhabitants of the Central Amazonia, Brazil

2015

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“…In recent years, the number of chronic CD cases detected at the Tropical Medicine Foundation ( Fundação de Medicina Tropical ) outpatient clinics has increased [4,5,12]. …”

Section: Introductionmentioning

confidence: 99%

Trypanosoma cruzi strain TcI is associated with chronic Chagas disease in the Brazilian Amazon

Santana

Magalhães

et al. 2014

Parasites Vectors

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BackgroundChagas disease in the Amazon region is considered an emerging anthropozoonosis with a predominance of the discrete typing units (DTUs) TcI and TcIV. These DTUs are responsible for cases of acute disease associated with oral transmission. Chronic disease cases have been detected through serological surveys. However, the mode of transmission could not be determined, or any association of chronic disease with a specific T. cruzi DTU’s. The aim of this study was to characterize Trypanosoma cruzi in patients with chronic Chagas disease in the State of Amazonas, Brazil.MethodsBlood culture and xenodiagnosis were performed in 36 patients with positive serology for Chagas disease who participated in a serological survey performed in urban and rural areas of Manaus, Amazonas. DNA samples were extracted from the feces of triatomines used for xenodiagnosis, and the nontranscribed spacer of the mini-exon gene and the mitochondrial gene cytochrome oxidase subunit II (COII) were amplified by PCR and sequenced.ResultsBlood culture and xenodiagnosis were negative in 100% of samples; however, molecular techniques revealed that in 13 out of 36 (36%) fecal samples from xenodiagnosis, T. cruzi was characterized as the DTU TcI, and different haplotypes were identified within the same DTU.ConclusionThe DTU TcI, which is mainly associated with acute cases of Chagas disease in the Amazon region, is also responsible for chronic infection in patients from a region in the State of Amazonas.

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Cardiopatia chagásica crônica na Amazônia: uma etiologia a ser lembrada

Abstract: SummaryThis study assessed the frequency of chronic chagasic cardiopathy (CCC) in 37 autochthonus patients from Amazon region with left ventricular systolic dysfunction of undefined etiology. Three cases were diagnosed in the studied sample, with an 8.1% frequency.

Cited by 6 publications

References 8 publications

Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

Piassaba palm extractivism as an associated factor with Chagas disease: seroprevalence and immunological profile in native inhabitants of the Central Amazonia, Brazil

Trypanosoma cruzi strain TcI is associated with chronic Chagas disease in the Brazilian Amazon

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