Frequência etiológica da hipertensão pulmonar em ambulatório de referência na Bahia

Machado, Cesar; Brito, Ísis; Souza, Denile; Correia, Luís Cláudio Lemos

doi:10.1590/s0066-782x2009001200019

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Clinical studies in SchPAH are scarce and restricted to a few PH centers in the world, largely in Brazil (67)(68)(69)(70)(71)(72)(73)(74)(75)(76). Additionally, most of the clinical data reported to date were generated in centers situated in non-endemic areas for schistosomiasis (62,64,65,(67)(68)(69).The classic comparator disease for SchPAH is IPAH, which occurs worldwide and has been much more widely studied despite a much lower disease burden (the incidence is approximately 1 case/million individuals/year) (77).…”

Section: Differences In Presentation and Prognosis Of Schpah Comparedmentioning

confidence: 99%

Schistosomiasis Pulmonary Arterial Hypertension

et al. 2020

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Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic schistosomiasis, particularly due to S. mansoni. The lung blood vessel injury may result from a combination of embolization of eggs through portocaval shunts into the lungs causing localized Type 2 inflammatory response and vessel remodeling, triggering of autonomous pathology that becomes independent of the antigen, and high cardiac output as seen in portopulmonary hypertension. The condition is likely underdiagnosed as there is little systematic screening, and risk factors for developing PAH are not known. Screening is done by echocardiography, and formal diagnosis requires invasive right heart catheterization. Patients with Schistosoma-associated PAH show reduced functional capacity and can be treated with pulmonary vasodilators, which improves symptoms and may improve survival. There are animal models of this disease that might help in understanding disease pathogenesis and identify novel targets to screen and treatment. Pathogenic mechanisms include Type 2 immunity and activation and signaling in the TGF-β pathway. There are still major uncertainties regarding Schistosoma-associated PAH development, course and treatment.

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Section: Differences In Presentation and Prognosis Of Schpah Comparedmentioning

confidence: 99%

Schistosomiasis Pulmonary Arterial Hypertension

et al. 2020

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“…The prevalence of elevated pulmonary pressures in patients with schistosomiasis is still controversial, but it has been reported as one of the most important etiologies of PAH 1-5,24,25 . This is the first study to assess the influence of gender on echocardiography-derived SPAP and to investigate the role of menopausal status and pregnancy history among patients diagnosed with SPAH.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Artery Pressure, Gender, Menopause, and Pregnancy in Schistosomiasis-Associated Pulmonary Hypertension

Armstrong

Bandeira

Correia

et al. 2013

Arquivos Brasileiros De Cardiologia

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BackgroundSchistosomiasis-associated pulmonary arterial hypertension (SPAH) is a major concern worldwide. However, the role of gender specific contributing factors in SPAH is unknown. ObjectiveWe investigated how systolic pulmonary artery pressure (SPAP) values and the presence of severe SPAP relate to gender, menopausal status, and pregnancy history in SPAH patients. MethodsSeventy-nine patients diagnosed with SPAH from 2000 to 2009 were assessed and 66 were enrolled in the study. Information about age, menopausal status, pregnancy, echocardiography-derived SPAP, and invasive mean pulmonary artery pressure (mPAP) was collected from medical records. The relation between values of SPAP and mPAP and their agreement for severe disease were assessed. Regression models assessed the association of gender, menopausal status, and pregnancy history with SPAP values and the presence of severe SPAP. ResultsModerate correlation and good agreement for severe disease were found between mPAP and SPAP. Mean SPAP values were similar for men and women. A trend toward higher values of SPAP was found for non-menopausal women compared to men. Higher SPAP values were found for menopausal compared to non-menopausal women; the values were non-significant after adjustment for age. Pregnancy history had no association with SPAP. Menopause and positive pregnancy had no association with severe SPAP. ConclusionIn SPAH patients, neither gender, nor menopausal status, nor pregnancy history showed independent correlation with SPAP values assessed by echocardiography.

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“…In Brazil, there are about 60,000 cases (Brito, 2017). A study in a reference outpatient clinic in Bahia identified the prevalence of idiopathic pulmonary arterial hypertension, followed by PH caused by schistosomiasis (Machado, et al, 2009); another carried out in two reference centers in São Paulo presented the same results, in addition to being associated with connective tissue diseases in 10% of the cases (Lapa et al, 2006). Studies reveal that PH occurs from the third decade of life in women, while in men the disease usually occurs from the age of forty (Health Care Secretariat, 2014).…”

Section: Pulmonary Hypertension Affects 25 Million People Worldwide (...mentioning

confidence: 93%

Validação de protocolo para assistência ao paciente com hipertensão pulmonar

Machado

Cogo²,

Jakitsch³

et al. 2022

RSD

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Introdução: A hipertensão pulmonar (HP) é uma doença grave definida pelo aumento da pressão dos vasos pulmonares. Trata-se de uma síndrome clínica, devido ao aumento da resistência vascular pulmonar, que ocorre por vasoconstrição e/ou degeneração do leito vascular dos pulmões causando perda progressiva da capacidade de trocas gasosas. Aponta-se a necessidade da elaboração e validação de um protocolo de cuidados ao paciente com hipertensão pulmonar internado em Unidades de Terapia Intensivas (UTIs) por meio da avaliação, por especialistas, de itens os quais se acredita serem pertinentes. Objetivo: Elaborar e validar um protocolo assistencial de cuidados ao paciente com hipertensão pulmonar na unidade de terapia intensiva. Método: Trata-se de estudo metodológico, de validação do conteúdo de um protocolo assistencial de cuidados ao paciente com hipertensão pulmonar, por meio da aplicação da técnica Delphi baseado no referencial teórico de Spínola. Resultados: Foram convidados 20 profissionais para participarem da avaliação do instrumento, dos quais 13 aceitaram participar, no entanto, 09 avaliadores participaram da primeira Rodada de Delphi. O constructo final permaneceu com 04 tópicos e 23 itens e não teve nenhum item retirado após avaliação dos experts. Conclusão: O protocolo para assistência ao paciente com hipertensão pulmonar é um instrumento prático e visa garantir a segurança do paciente e a qualidade da assistência prestada articulada aos avanços tecnológicos. Acredita-se que o protocolo contribuirá para que a equipe multiprofissional promova uma assistência segura, precisa e eficiente ao paciente com hipertensão pulmonar nas unidades de terapia intensivas.

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Frequência etiológica da hipertensão pulmonar em ambulatório de referência na Bahia

Cited by 5 publications

References 22 publications

Schistosomiasis Pulmonary Arterial Hypertension

Schistosomiasis Pulmonary Arterial Hypertension

Pulmonary Artery Pressure, Gender, Menopause, and Pregnancy in Schistosomiasis-Associated Pulmonary Hypertension

Validação de protocolo para assistência ao paciente com hipertensão pulmonar

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