Associação do índice de massa corporal e da resistência à insulina com síndrome metabólica em crianças brasileiras

Ferreira, Aparecido Pimentel; Nóbrega, Otávio de Tolêdo; França, Nanci Maria de

doi:10.1590/s0066-782x2009000800013

Cited by 19 publications

(12 citation statements)

References 33 publications

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“…Studies sought to determine the features associated with MS in different age groups. In the present study, there was a higher correlation coefficient between the number of factors for MS and BMI, when compared to other measures of body composition ( 8 ) . The presence of risk factors for MS seems to be more frequent in obese children compared to those with normal weight or overweight, demonstrating that increased values of BMI increase the occurrence of other risk factors for MS ( 2 , 8 ) .…”

Section: Discussioncontrasting

confidence: 55%

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Metabolic syndrome and insulin resistance in obese adolescents

Gobato

Vasques

Zambon

et al. 2014

Rev. paul. pediatr.

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Objective: To verify the prevalence of metabolic syndrome and insulin resistance in obese adolescents and its relationship with different body composition indicators. Methods: A cross-sectional study comprising 79 adolescents aged ten to 18 years old. The assessed body composition indicators were: body mass index (BMI), body fat percentage, abdominal circumference, and subcutaneous fat. The metabolic syndrome was diagnosed according to the criteria proposed by Cook et al. The insulin resistance was determined by the Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) index for values above 3.16. The analysis of ROC curves was used to assess the BMI and the abdominal circumference, aiming to identify the subjects with metabolic syndrome and insulin resistance. The cutoff point corresponded to the percentage above the reference value used to diagnose obesity. Results: The metabolic syndrome was diagnosed in 45.5% of the patients and insulin resistance, in 29.1%. Insulin resistance showed association with HDL-cholesterol (p=0.032) and with metabolic syndrome (p=0.006). All body composition indicators were correlated with insulin resistance (p<0.01). In relation to the cutoff point evaluation, the values of 23.5 and 36.3% above the BMI reference point allowed the identification of insulin resistance and metabolic syndrome. The best cutoff point for abdominal circumference to identify insulin resistance was 40%. Conclusions: All body composition indicators, HDL-cholesterol and metabolic syndrome showed correlation with insulin resistance. The BMI was the most effective anthropometric indicator to identify insulin resistance.

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Section: Discussioncontrasting

confidence: 55%

“…Indicators of body composition are strongly associated with metabolic changes, and it is important to verify their relationship with components of metabolic syndrome ( 7 , 8 ) and with insulin resistance ( 2 , 9 , 10 ) .…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome and insulin resistance in obese adolescents

Gobato

Vasques

Zambon

et al. 2014

Rev. paul. pediatr.

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“…13 Lavrador et al observaram, em amostra de 80 adolescentes obesos pós-púberes divididos em obesos com menor e maior grau de obesidade, que aqueles com maior grau de obesidade apresentavam maiores frequências de alterações para glicemia, HOMA-IR, triglicerídeos, HDL e pressão arterial, demonstrando que o grau de obesidade influenciou no aparecimento de alterações clínicas e metabólicas. 7 Em estudo de caso controle, que avaliou a relação de fatores de risco para doença cardiovascular com RI em 52 crianças, observou-se que as obesas apresentavam alta prevalência de SM. O método de distribuir a amostra, segundo os quartis do índice HOMA-IR das crianças e dos adolescentes avaliados, confirmou que quanto maiores os valores do HOMA-IR, maiores eram os valores de IMC, medida da CA e triglicerídeos, e menores os valores de HDL-C, em consonância com outros estudos, como o de Ferreira et al, que avaliou a associação do IMC e da RI com a SM em crianças brasileiras.…”

Section: Resultsunclassified

Insulin resistance in obese children and adolescents

Romualdo

Nóbrega

Escrivão

2014

Jornal de Pediatria (Versão em Português)

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Objective: To evaluate the presence of insulin resistance and its association with other metabolic abnormalities in obese children and adolescents. Methods: Retrospective study of 220 children and adolescents aged 5-14 years. Anthropometric measurements were performed (weight, height, and waist circumference) and clinical (gender, age, pubertal stage, and degree of obesity) and biochemical (glucose, insulin, total cholesterol, and fractions, triglycerides) data were analyzed. Insulin resistance was identified by the homeostasis model assessment for insulin resistance (HOMA-IR) index. The analysis of the differences between the variables of interest and the HOMA-IR quartiles was performed by ANOVA or Kruskal-Wallis tests. Results: Insulin resistance was diagnosed in 33.20% of the sample. It was associated with low levels of high-density lipoprotein cholesterol (HDL-C; p = 0.044), waist circumference measurement (p = 0.030), and the set of clinical and metabolic (p = 0.000) alterations. Insulin-resistant individuals had higher mean age (p = 0.000), body mass index (BMI; p = 0.000), abdominal circumference (p = 0.000), median triglycerides (p = 0.001), total cholesterol (p ≤ 0.042), and low-density lipoprotein cholesterol (LDL---C; p ≤ 0.027); and lower HDL-C levels (p = 0.005). There was an increase in mean BMI (p = 0.000), abdominal circumference (p = 0.000), and median DOI se refere ao artigo: http://dx.Insulin resistance in obese children and adolescents 601 triglycerides (p = 0.002) as the values of HOMA -IR increased, with the exception of HDL-C, which decreased (p = 0.001). Those with the highest number of simultaneous alterations were between the second and third quartiles of the HOMA---IR index (p = 0.000). Conclusion: The results confirmed that insulin resistance is present in many obese children and adolescents, and that this condition is associated with alterations that represent an increased risk for developing metabolic disorders in adulthood. Resistência à insulina em crianças e adolescentes obesos ResumoObjetivo: Avaliar a presença de resistência à insulina e sua relação com outras alterações metabólicas, em crianças e adolescentes obesos. Métodos: Estudo retrospectivo de 220 crianças e adolescentes de 5 a 14 anos. Foram realizadas avaliações antropométricas (peso, estatura e circunferência abdominal), clínicas (sexo, idade, estágio puberal e grau de obesidade) e bioquímicas (glicemia, insulina, colesterol total e frações, triglicerídeos). A resistência à insulina foi identificada pelo índice HOMA-IR. A análise das diferenças entre as variáveis de interesse e os quartis do HOMA-IR foi realizada pelos testes ANOVA ou Kruskal-Wallis. Resultados: A resistência à insulina foi diagnosticada em 33,20% da amostra. Associou-se a níveis baixos de HDL-C (p = 0,044), medida da circunferência abdominal aumentada (p = 0,030) e ao conjunto de alterações clínicas e metabólicas (p = 0,000). Os indivíduos resistentes apresentaram maiores médias de idade (p = 0,000), IMC (p = 0,000), medida da circunferência abdominal...

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“…Some studies point to the hypothesis that the negative impact of increased amount of adipose tissue in the body on insulin sensitivity can be clearly demonstrated in most individuals, as well as increased insulin sensitivity observed with body weight reduction and physical exercise 40 .…”

Section: Discussionmentioning

confidence: 99%

“…Despite the lack of a unanimous hypothesis about the pathophysiological pathways that lead to the emergence of metabolic syndrome, it is suggested that plasma insulin levels, as well as the simple evaluation of BMI, are valuable indicators of clinical disorders compatible with MS in children 40 .…”

Section: Discussionmentioning

confidence: 99%