BackgroundRecent studies have suggested that B-type Natriuretic Peptide (BNP) is an
important predictor of ischemia and death in patients with suspected acute
coronary syndrome. Increased levels of BNP are seen after episodes of myocardial
ischemia and may be related to future adverse events.ObjectivesTo determine the prognostic value of BNP for major cardiac events and to evaluate
its association with ischemic myocardial perfusion scintigraphy (MPS).MethodsThis study included retrospectively 125 patients admitted to the chest pain unit
between 2002 and 2006, who had their BNP levels measured on admission and
underwent CPM for risk stratification. BNP values were compared with the results
of the MPS. The chi-square test was used for qualitative variables and the Student
t test, for quantitative variables. Survival curves were adjusted using the
Kaplan-Meier method and analyzed by using Cox regression. The significance level
was 5%.ResultsThe mean age was 63.9 ± 13.8 years, and the male sex represented 51.2% of
the sample. Ischemia was found in 44% of the MPS. The mean BNP level was higher in
patients with ischemia compared to patients with non-ischemic MPS (188.3 ±
208.7 versus 131.8 ± 88.6; p = 0.003). A BNP level greater than 80 pg/mL
was the strongest predictor of ischemia on MPS (sensitivity = 60%, specificity =
70%, accuracy = 66%, PPV = 61%, NPV = 70%), and could predict medium-term
mortality (RR = 7.29, 95% CI: 0.90-58.6; p = 0.045) independently of the presence
of ischemia.ConclusionsBNP levels are associated with ischemic MPS findings and adverse prognosis in
patients presenting with acute chest pain to the emergency room, thus, providing
important prognostic information for an unfavorable clinical outcome.