Inibidores da glicoproteína IIb/IIIa na prática clínica

Platelet activation and subsequent thrombus formation at sites of vascular injury is crucial for normal hemostasis, but it can also cause myocardial infarction and stroke. The initial capture of flowing platelets to the injured vessel wall is mediated by the interaction of the glycoprotein (GP) Ib-V-IX complex with von Willebrand factor immobilized on the exposed subendothelial extracellular matrix. Tethered platelets are then able to bind to collagens through the immunoglobulin-like receptor GPVI and to initiate cellular activation, a process that is reinforced by G protein-coupled receptors stimulated by locally produced thrombin and soluble mediators released from activated platelets. These signaling events lead to a rise in the cytosolic Ca(2+) concentration, rearrangement of the cytoskeleton, release of granule content, and functional upregulation of integrin adhesion receptors allowing firm adhesion and thrombus growth. Fully activated platelets also undergo a procoagulant conversion thereby facilitating coagulation and thrombus stabilization. This review summarizes the most important receptor systems and signaling mechanisms involved in platelet activation and thrombus formation with special focus on recent discoveries.

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Platelet receptor signaling in thrombus formation

Stegner

2010

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Effects of the Chinese patent medicine, Honghua Injection, on platelet glycoprotein Ⅱb/Ⅲa receptors in patients with acute coronary syndrome: a randomized controlled trial

Zhu

Luo²,

Zhonglong³

et al. 2012

J Chin Integr Med

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Inibidores da glicoproteína IIb/IIIa na prática clínica

Abstract: Agregação plaquetária, inibidores dos receptores da glicoproteína IIb/IIIa da membrana de plaquetas, intervenção coronária percutânea.

Cited by 2 publications

References 38 publications

Platelet receptor signaling in thrombus formation

Platelet receptor signaling in thrombus formation

Effects of the Chinese patent medicine, Honghua Injection, on platelet glycoprotein Ⅱb/Ⅲa receptors in patients with acute coronary syndrome: a randomized controlled trial

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