O sistema apelinérgico: papel na fisiologia e patologia humanas e potenciais aplicações terapêuticas

Ladeiras-Lopes, Ricardo; Ferreira-Martins, João; Leite‐Moreira, Adelino F.

doi:10.1590/s0066-782x2008000500012

Cited by 34 publications

(13 citation statements)

References 66 publications

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“…Apelin is a hormone with cardiovascular properties and impact on glucose homoeostasis [28,29]. Apelin is secreted and expressed by human adipocytes and up-regulated by insulin and obesity [30].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, inhibition of apelin signaling during frog embryonic development resulted in severe reduction in the formation of vascular structures [33]. A most recent study on the pathophysiologic role played by apelin showed that intraperitoneal administration in normal and obese mice for 14 days reduced body fat without affecting food intake, reduced insulin, leptin and triglycerides level and respiratory quotient [29]. It is mentioned that Apelin might have different effects, depending on whether it is acting in brain or peripherally [32].…”

Section: Discussionmentioning

confidence: 99%

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Leptin, Obestatin and Apelin levels in patients with obstructive sleep apnoea syndrome

et al. 2011

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SummaryBackgroundRecent studies suggest that adipose tissue hormones are involved in the pathogenesis of obstructive sleep apnoea syndrome (OSAS). The role of leptin, obestatin and apelin still needs to be established.Material/MethodsTen patients with newly diagnosed OSAS (AHI >10/h and ESS >10 points) were enrolled in the study as well as ten healthy volunteers as controls. All underwent measurements for Leptin, Obestatin and Apelin in four hour intervals during diagnostic polysomnography for 24 h and the patients also three months after onset of CPAP treatment. Furthermore the HOMA-index and body composition were quantified.ResultsPlasma apelin levels in the patients decreased under CPAP therapy, but showed no significant difference in patients and volunteers. We found a positive correlation to AHI, BMI in the therapy group at all observation points.Leptin plasma levels were higher in the patient group and decreased after onset of CPAP therapy. Leptin plasma levels were positively correlated to the BMI, min. 02 and AHI in the patient group before therapy.Plasma obestatin levels did not differ significantly in these three observation groups, but were partly correlated to AHI and weight in the newly diagnosed OSAS group.ConclusionsIn agreement with previous investigations, we could demonstrate a difference in leptin plasma levels between healthy volunteers and patients with newly diagnosed OSAS. Apelin decreases under CPAP therapy, but not significantly.Obestatin remains unchanged after onset of CPAP. We further found a linkage between leptin plasma levels and BMI, AHI and weight in the untreated patient group.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Leptin, Obestatin and Apelin levels in patients with obstructive sleep apnoea syndrome

et al. 2011

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“…Apelin (Apln) plays a role in normal glucolipidic metabolism [78] and has had conflicting results in previous experiments. The results of the present study agree with the results previous results of low plasma levels in type II diabetic Chinese humans [79,80].…”

Section: Discussionmentioning

confidence: 99%

Gene expression of sternohyoid and diaphragm muscles in type 2 diabetic rats

Lunteren

Moyer

2013

BMC Endocr Disord

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BackgroundType 2 diabetes differs from type 1 diabetes in its pathogenesis. Type 1 diabetic diaphragm has altered gene expression which includes lipid and carbohydrate metabolism, ubiquitination and oxidoreductase activity. The objectives of the present study were to assess respiratory muscle gene expression changes in type 2 diabetes and to determine whether they are greater for the diaphragm than an upper airway muscle.MethodsDiaphragm and sternohyoid muscle from Zucker diabetic fatty (ZDF) rats were analyzed with Affymetrix gene expression arrays.ResultsThe two muscles had 97 and 102 genes, respectively, with at least ± 1.5-fold significantly changed expression with diabetes, and these were assigned to gene ontology groups based on over-representation analysis. Several significantly changed groups were common to both muscles, including lipid metabolism, carbohydrate metabolism, muscle contraction, ion transport and collagen, although the number of genes and the specific genes involved differed considerably for the two muscles. In both muscles there was a shift in metabolism gene expression from carbohydrate metabolism toward lipid metabolism, but the shift was greater and involved more genes in diabetic diaphragm than diabetic sternohyoid muscle. Groups present in only diaphragm were blood circulation and oxidoreductase activity. Groups present in only sternohyoid were immune & inflammation and response to stress & wounding, with complement genes being a prominent component.ConclusionType 2 diabetes-induced gene expression changes in respiratory muscles has both similarities and differences relative to previous data on type 1 diabetes gene expression. Furthermore, the diabetic alterations in gene expression differ between diaphragm and sternohyoid.

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“…First and most importantly, all of the genes are expressed in the central nervous system or brain in normal tissues and have all been linked to a neurological-related phenotype or function in the mouse model [61]. APLN has been shown to play a critical role in fluid homeostasis and pressure/volume homeostasis in the brain [62]. This particular function is of utmost importance to the developing brain and research has shown that APLN is involved in modifications of the microvasculature in the immature brain, affecting cerebral blood flow during a hypoxic insult [63].…”

Section: Discussionmentioning

confidence: 99%

A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis

et al. 2011

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BackgroundSeveral computational candidate gene selection and prioritization methods have recently been developed. These in silico selection and prioritization techniques are usually based on two central approaches - the examination of similarities to known disease genes and/or the evaluation of functional annotation of genes. Each of these approaches has its own caveats. Here we employ a previously described method of candidate gene prioritization based mainly on gene annotation, in accompaniment with a technique based on the evaluation of pertinent sequence motifs or signatures, in an attempt to refine the gene prioritization approach. We apply this approach to X-linked mental retardation (XLMR), a group of heterogeneous disorders for which some of the underlying genetics is known.ResultsThe gene annotation-based binary filtering method yielded a ranked list of putative XLMR candidate genes with good plausibility of being associated with the development of mental retardation. In parallel, a motif finding approach based on linear discriminatory analysis (LDA) was employed to identify short sequence patterns that may discriminate XLMR from non-XLMR genes. High rates (>80%) of correct classification was achieved, suggesting that the identification of these motifs effectively captures genomic signals associated with XLMR vs. non-XLMR genes. The computational tools developed for the motif-based LDA is integrated into the freely available genomic analysis portal Galaxy (http://main.g2.bx.psu.edu/). Nine genes (APLN, ZC4H2, MAGED4, MAGED4B, RAP2C, FAM156A, FAM156B, TBL1X, and UXT) were highlighted as highly-ranked XLMR methods.ConclusionsThe combination of gene annotation information and sequence motif-orientated computational candidate gene prediction methods highlight an added benefit in generating a list of plausible candidate genes, as has been demonstrated for XLMR.Reviewers: This article was reviewed by Dr Barbara Bardoni (nominated by Prof Juergen Brosius); Prof Neil Smalheiser and Dr Dustin Holloway (nominated by Prof Charles DeLisi).

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O sistema apelinérgico: papel na fisiologia e patologia humanas e potenciais aplicações terapêuticas

Cited by 34 publications

References 66 publications

Leptin, Obestatin and Apelin levels in patients with obstructive sleep apnoea syndrome

Leptin, Obestatin and Apelin levels in patients with obstructive sleep apnoea syndrome

Gene expression of sternohyoid and diaphragm muscles in type 2 diabetic rats

A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis

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