Eficácia da atorvastatina sem administração diária

Ghattas, Antonio Edmond; Pimenta, João

doi:10.1590/s0066-782x2007001700008

Cited by 3 publications

(1 citation statement)

References 20 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…11 Atorvastatin can be administered on alternate day and a cost reduction between 30% and 50% can be achieved. 12 Statins, like all other pharmacological treatments, inevitably have adverse effects. The major adverse effect associated with statin use is myopathy.…”

Section: Introductionmentioning

confidence: 99%

An open-label prospective observational study to evaluate the efficacy and safety of alternate day versus daily dosing of atorvastatin in patients of dyslipidemia

Gulam Mohammad,

Shivangna Singh,

Priti Singh

et al. 2024

Asian J Med Sci

View full text Add to dashboard Cite

Background: Hypercholesterolemia is a main driver of atherosclerosis. Cholesterol-containing lipoproteins induce endothelial dysfunction and macrophage activation. Foam cell formation results from the uptake of cholesterol-containing lipoproteins by macrophages, it is an essential step in the initiation and progression of atherosclerosis. Aims and Objectives: To evaluate the efficacy and safety of alternate day versus daily dosing of atorvastatin in patients with dyslipidemia. Materials and Methods: This open-label, prospective, observational study was conducted on dyslipidemic patients who came into the medicine Outpatient Department of Dhanalakshmi Srinivasan Medical College and Hospital, Tamil Nadu. Approval for the study was taken from the Institutional Ethical Committee. The duration of the study was 3 months. The efficacy of atorvastatin was checked by noting their blood lipid profile status. Results: Out of 100 patients included in the study 79 completed the study whereas 21 patients were lost in follow-up, 42 patients were analyzed in daily dose (Group A), and 37 patients in alternate dose (Group B) of atorvastatin (20 mg). There was no statistically significant difference based on triglyceride, total cholesterol, low-density lipoprotein, and high-density lipoprotein levels both prior and post-treatment in both the groups. Adverse drug reactions (ADR) profile showed a statistically significant difference between both the groups after treatment by atorvastatin (P=0.0001), with more ADRs noted in a daily dosing group. Conclusion: The results of this study show that alternate dosing of atorvastatin was better tolerated than daily dosing hence physicians can consider choosing an alternate day therapy to reduce pill burden on patients.

show abstract

Section: Introductionmentioning

confidence: 99%

An open-label prospective observational study to evaluate the efficacy and safety of alternate day versus daily dosing of atorvastatin in patients of dyslipidemia

Gulam Mohammad,

Shivangna Singh,

Priti Singh

et al. 2024

Asian J Med Sci

View full text Add to dashboard Cite

show abstract

Alternate-day versus daily atorvastatin in coronary artery disease: a randomized study

Rifaie¹,

Ahmed²,

Nammas³

2012

Anadolu Kardiyol Derg

View full text Add to dashboard Cite

Objective: We sought to compare the effect of alternate-day versus daily atorvastatin 10 mg, on serum low-density lipoprotein cholesterol (LDL-C) and high-sensitivity C-reactive protein (hs-CRP) in patients with coronary artery disease (CAD) and controlled serum LDL-C by daily atorvastatin. Methods: The study was prospective, randomized, single-blinded, two-armed. Randomization was performed by a computer-generated randomization list. We randomized 60 patients with CAD and controlled serum LDL-C to receive either atorvastatin in the standard-dose of 10 mg daily (Group A=30 patients), or the same medication every other day (Group B=30 patients). Primary efficacy criterion included changes in serum LDL-C and hs-CRP from the initial to the 6-week follow-up values.

show abstract

Alternate Day versus Once Daily Atorvastatin for Primary Prevention of (CHD) in Naïve Patients of Dyslipidemia

Ghia

Panda

Khobragade

et al. 2014

JCDR

View full text Add to dashboard Cite

Eficácia da atorvastatina sem administração diária

Abstract: The results suggest that atorvastatin may be administered on a non-daily basis. A cost reduction between 30% and 50% was also observed.

Cited by 3 publications

References 20 publications

An open-label prospective observational study to evaluate the efficacy and safety of alternate day versus daily dosing of atorvastatin in patients of dyslipidemia

An open-label prospective observational study to evaluate the efficacy and safety of alternate day versus daily dosing of atorvastatin in patients of dyslipidemia

Alternate-day versus daily atorvastatin in coronary artery disease: a randomized study

Alternate Day versus Once Daily Atorvastatin for Primary Prevention of (CHD) in Naïve Patients of Dyslipidemia

Contact Info

Product

Resources

About