Efeitos do betacaroteno e do tabagismo sobre a remodelação cardíaca pós-infarto do miocárdio

Zornoff, Leonardo A. M.; Duarte, Delfim; Minicucci, Marcos F.; Azevedo, Paula S.; Matsubara, Beatriz Bojikian; Matsubara, Luiz Shiguero; Campana, Álvaro Oscar; Paiva, Sérgio Alberto Rupp de

doi:10.1590/s0066-782x2007001500002

Cited by 6 publications

(4 citation statements)

References 21 publications

(28 reference statements)

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“…Rafacho et al also showed that after two months of ETS there was a decrease in the cardiac activity of antioxidant enzymes and an increase in LH [ 5 ]. Notably, supplementation with pentoxifylline, retinoic acid and beta-carotene, substances with antioxidant properties, have been shown to attenuate the ventricular remodeling process induced by smoking [ 37 – 40 ]. However, despite all the evidence showing the major role of ETS in cardiac oxidative damage, no study, until now, has analyzed the participation of lipid peroxidation, protein oxidation and DNA damage as targets of oxidative stress induced by exposure to cigarette smoke in this model.…”

Section: Discussionmentioning

confidence: 99%

Lipid damage is the best marker of oxidative injury during the cardiac remodeling process induced by tobacco smoke

Lourenço

Braz

Aun

et al. 2018

BMC Pharmacol Toxicol

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BackgroundOxidative stress is one potential mechanism that explain the direct effects of smoking on cardiac remodeling process. However, no study has compared different myocardial products of macromolecule oxidation after tobacco smoke exposure. Thus, the aim of this study was to investigate the lipid hydroperoxide (LH) levels, protein carbonyl concentrations and DNA damage in cardiac tissue of rats exposed to tobacco smoke.MethodsMale Wistar rats were divided into two groups: group C (control, n = 14) composed of animals not exposed to cigarette smoke; group ETS (exposed to tobacco smoke, n = 14) composed by animals exposed to cigarette smoke. The animals were exposed to 2 month of ETS and morphological, biochemical and functional analyses were performed.ResultsCardiac cotinine levels were elevated in the ETS group. In addition, the myocyte cross-sectional area was higher in the ETS group. (C = 266.6 ± 23.2 μm2 and ETS = 347.5 ± 15.1 μm2, p < 0.001). Cardiac LH was higher in the ETS group than in group C (C = 196.4 ± 51.5 nmol/g and ETS = 331.9 ± 52.9 nmol/g, p < 0.001). However, there were no between-group differences in cardiac protein carbonyl concentration or DNA damage.ConclusionsTherefore, our results suggest that, in this model, lipid damage is a good marker of oxidative damage during the cardiac remodeling process induced by 2 months of exposure to tobacco smoke.

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Section: Discussionmentioning

confidence: 99%

Lipid damage is the best marker of oxidative injury during the cardiac remodeling process induced by tobacco smoke

Lourenço

Braz

Aun

et al. 2018

BMC Pharmacol Toxicol

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“…Exposure of normal rats or rats after infarction to cigarette smoke resulted in the intensifi cation of remodeling accompanied by worsening of functional variables. Cigarette smoke -exposed animals receiving β -carotene dietary supplements showed an intensifi cation of heart remodeling and the harmful effects of the remodeling process, such as increase in left atrium area, myocyte cross -section area, left ventricular systolic and diastolic sizes, were heightened [134] .…”

Section: Dietary Interventions With Mixed Effects On Cigarette Smoke mentioning

confidence: 99%

Interfering with Smoking‐Induced Pathophysiology

Csordás

2011

Cigarette Smoke Toxicity

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“…Alguns modelos foram desenvolvidos. A bomba sanguínea espiral mostrou resolutividade por gerar escoamento e pressão adequados, sem causar danos excessivos aos elementos figurados do sangue (37) . Um modelo de coração isolado desenvolvido tipo working heart se manteve estável durante a duração dos experimentos, sem a administração de drogas cardiotônicas, e possibilitou a mensuração de todos os dados propostos de forma efetiva com o coração executando trabalho (38) .…”

Section: Cardiologiaunclassified

Artigos publicados em periódicos brasileiros de interesse para a medicina do exercício e do esporte: uma revisão

Hernandez¹

2009

Rev Bras Med Esporte

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RESUMoEsta nova série de artigos tem por objetivo levar aos leitores nacionais e internacionais algumas das mais importantes contribuições provenientes da literatura médica brasileira recente. Embora possa parecer que não tenham relação direta com a Medicina do Exercício e do Esporte, são trabalhos que podem oferecer suporte a muitas linhas de pesquisa nessa área. Os artigos originais mais relevantes são selecionados por experientes editores, a quem solicitamos que escolham palavras-chave para que sejam destacadas para chamar a atenção do leitor. Para facilitar a leitura, os artigos são organizados por área de interesse. Para aproveitar ao máximo o limitado espaço editorial, não são incluídos os nomes dos autores dos artigos. Entretanto, a referência completa é oferecida ao final do artigo. O resultado final traz o que há de melhor do artigo, seguido de uma sintética interpretação pessoal. Endereçado ao médico ocupado, esperamos que esta inciativa possa contribuir para o sucesso da translação do conhecimento da evidência científica para a prática clínica. Palavras-chave: medicina esportiva, cardiologia, ortopedia, nutrição. aBStRaCtThis brand-new series of articles aims at delivering to national and international readers some of the cutting-edge contributions from the Brazilian medical literature. Some of them may not be directly related to the area, but they can be the grounding for scientific research in the field of Sports and Exercise Medicine. Recently, papers published in the main Brazilian medical journals are carefully selected and analyzed by skilled medical editors. In addition, we asked editors to choose keywords to be highlighted in order to call the reader' s attention. Articles are organized by area of interest to facilitate reading. To get the most of the limited available editorial space we did not include the names of the authors of the related articles in the text itself, but a complete reference guide is provided at the end of the article. The result carries the best from the original paper accompanied by a personal interpretation. Directed to the busy medical doctor, we hope that this initiative may contribute to the successful translation of knowledge from scientific evidence to clinical practice.

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Efeitos do betacaroteno e do tabagismo sobre a remodelação cardíaca pós-infarto do miocárdio

Abstract: After myocardial infarction, smoking and beta-carotene intensified the heart remodeling process; harmful effects of the remodeling process were heightened when the two treatments were used in conjunction.

Cited by 6 publications

References 21 publications

Lipid damage is the best marker of oxidative injury during the cardiac remodeling process induced by tobacco smoke

Lipid damage is the best marker of oxidative injury during the cardiac remodeling process induced by tobacco smoke

Interfering with Smoking‐Induced Pathophysiology

Artigos publicados em periódicos brasileiros de interesse para a medicina do exercício e do esporte: uma revisão

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