A exposição à fumaça de cigarro intensifica a remodelação ventricular após o infarto agudo do miocárdio

Abstract

Cigarette smoke exposure intensifies ventricular remodeling following acute myocardial infarction.

Efeitos do betacaroteno e do tabagismo sobre a remodelação cardíaca pós-infarto do miocárdio

“…In this study, animals exposed to cigarette smoke presented increased LV systolic and diastolic dimensions and increased myocyte cross-section as compared with control animals. We can therefore infer that exposure to cigarette smoke intensified the process of ventricular remodeling after infarction, which is in agreement with previously mentioned studies 6,7 .…”

“…In a recent study carried out in our laboratory, exposure to cigarette smoke for six months after AMI led to intensification in remodeling 6 . In this context, it is important to consider that oxidative stress is accepted as one of the most important modulators of post-AMI ventricular remodeling [7][8][9] .…”

Comparação de diferentes métodos para medida do tamanho do infarto experimental crônico em Ratos

“…The acute infarction was produced in accordance with the previously described method 10,11 . In short, the rats were anesthetized with ether and undewent left lateral thoracotomies.…”

“…Echocardiograph Study -After an observation period of 3 to 6 months, the surviving animals (n = 122) were anesthetized with cetamine chloride (50 mg/kg) and xylidine chloride (1 mg/kg) that was injected in the muscle for the echocardiograph study 11 . After trichotomy of the anterior chest region, the animals were placed in the supine position in a specially designed channel that enabled slight lateral left rotation for the test that was conducted using Philips equipment (model TDI 5500) with an electronic transducer with a multi-frequency range of up to 12 MHz.…”

Influência da taurina na remodelação cardíaca induzida pela exposição à fumaça do cigarro

“…Acompanhando essas alterações, o tabagismo resulta em queda de parâmetros de função sistólica e diastólica, tanto in vivo, como in vitro. Sendo assim, evidências sugerem que a exposição ao fumo pode modular o processo de remodelação ventricular (11,12,13,14,15) .…”