Monocitose é um marcador de risco independente para a doença arterial coronariana

Neto, Abrahão Afiune; Mansur, Antônio de Pádua; Avakian, Solange Desirée; Gomes, Everly P S G; Ramires, José Antônio Franchini

doi:10.1590/s0066-782x2006000300013

Cited by 26 publications

(6 citation statements)

References 20 publications

(15 reference statements)

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“…However, monocytes may also play a role in asthma as they produce cytokines and are involved in oxidative stress, influencing the phenotype and function of subsequent macrophages/dendritic cells and T helper cells [32,33]. Monocytes, key immune cells in the blood, have been used to describe the severity of inflammation in other diseases such as ischemic stroke and allergic rhinitis [33][34][35]. Although newly recruited monocyte-derived macrophages have been shown to be associated with eosinophilic airway inflammation [36], the role of monocytes in the pathogenesis of asthma is not yet fully elucidated.…”

Section: Asthmamentioning

confidence: 99%

Exploring the Causal Link Between Immune Cell Phenotypes and Asthma Through Two-Sample and Bayesian Weighted Mendelian Randomization

Kaihao,

Lizhao,

et al. 2024

Preprint

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Objective: Using two-sample Mendelian Randomization (MR) and Bayesian Weighted Mendelian Randomization (BWMR), this study explores the causal links between 731 immune cell phenotypes and asthma, providing useful biomarkers for potential therapeutic targets for asthma. Methods: The study employed two-sample MR and BWMR to evaluate the causal relationships between 731 immune cell phenotypes and asthma, using large-scale Genome-Wide Association Study (GWAS) datasets to exclude confounding factors and conduct various sensitivity analyses. Results: The study conducted an in-depth analysis of the causal relationship between 731 immune cell phenotypes and asthma across three databases (ebi, finn, and ukb). Integrating the results from IVW and BWMR across these databases, we identified CD16+ monocyte %monocyte as a protective factor against asthma, whereas CD62L- myeloid Dendritic Cell Absolute Count, CD62L- myeloid Dendritic Cell %Dendritic Cell, CD62L- CD86+ myeloid Dendritic Cell Absolute Count, and CD62L- CD86+ myeloid Dendritic Cell %Dendritic Cell were identified as risk factors. Conclusion: Our research confirms that CD16+ monocyte %monocyte serves as a protective factor against asthma, while CD62L- myeloid Dendritic Cell Absolute Count, CD62L- myeloid Dendritic Cell %Dendritic Cell, CD62L- CD86+ myeloid Dendritic Cell Absolute Count, and CD62L- CD86+ myeloid Dendritic Cell %Dendritic Cell pose risks for asthma.

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Section: Asthmamentioning

confidence: 99%

Exploring the Causal Link Between Immune Cell Phenotypes and Asthma Through Two-Sample and Bayesian Weighted Mendelian Randomization

Kaihao,

Lizhao,

et al. 2024

Preprint

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“…Thirdly, IHD promoting systemic responses, of which for example efflorescence of clonal hematopoiesis (CH) in bone marrow [ 62 , 63 , 64 , 65 , 66 ] and splenic hematopoiesis seeding proinflammatory monocytes [ 63 , 67 , 68 ] can be expected to alter blood epitranscriptomic signatures. Mechanistically, these postulations are suggested from notions that: (1) some leukocytes (1a) do exit the plaques [ 69 ], and (1b) oscillate between circulation and ischemic myocardium [ 70 , 71 ], (2) monocytosis has been independently associated with stable IHD and MI [ 72 , 73 ], (3) m 6 A has been shown to partake in dendritic cell (specialized monocytes) activation [ 74 ], (4) METTL3-mediated m 6 A-hypermethylation seems to act as a downstream elicitor of atherogenesis in vascular endothelium in response to disturbed flow and oscillatory shear stress [ 75 ], (5) the plaques, juxtaposed platelets, and ischemic myocardium are known to shed EVs to circulation encasing unique miRNAs [ 59 , 76 , 77 , 78 , 79 , 80 , 81 ], (6) miRNAs in such EVs have recently been shown to be epitranscriptomically modified [ 82 ], (7) epitranscriptomic and epigenetic regulators (7a) are often noted as CH driver mutations [ 83 ], and (7b) are pivotal for proliferation of hematopoietic stem cells (HSCs) [ 31 , 84 , 85 , 86 , 87 , 88 ]. Based on this rationale, the IHD-EPITRAN study aims to identify novel epitranscriptomic biomarkers and drug therapy targets for IHD from blood ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Epitranscriptomics of Ischemic Heart Disease—The IHD-EPITRAN Study Design and Objectives

Sikorski

Karjalainen

Blokhina

et al. 2021

IJMS

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Epitranscriptomic modifications in RNA can dramatically alter the way our genetic code is deciphered. Cells utilize these modifications not only to maintain physiological processes, but also to respond to extracellular cues and various stressors. Most often, adenosine residues in RNA are targeted, and result in modifications including methylation and deamination. Such modified residues as N-6-methyl-adenosine (m6A) and inosine, respectively, have been associated with cardiovascular diseases, and contribute to disease pathologies. The Ischemic Heart Disease Epitranscriptomics and Biomarkers (IHD-EPITRAN) study aims to provide a more comprehensive understanding to their nature and role in cardiovascular pathology. The study hypothesis is that pathological features of IHD are mirrored in the blood epitranscriptome. The IHD-EPITRAN study focuses on m6A and A-to-I modifications of RNA. Patients are recruited from four cohorts: (I) patients with IHD and myocardial infarction undergoing urgent revascularization; (II) patients with stable IHD undergoing coronary artery bypass grafting; (III) controls without coronary obstructions undergoing valve replacement due to aortic stenosis and (IV) controls with healthy coronaries verified by computed tomography. The abundance and distribution of m6A and A-to-I modifications in blood RNA are charted by quantitative and qualitative methods. Selected other modified nucleosides as well as IHD candidate protein and metabolic biomarkers are measured for reference. The results of the IHD-EPITRAN study can be expected to enable identification of epitranscriptomic IHD biomarker candidates and potential drug targets.

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“…Atherosclerosis or Coronary Arterial Disease is characterized by a chronic inflammatory disease of multifactorial origin that affects the deepest layer of large and medium calibre arteries [1]. This pathological manifestation occurs by the appearance of plaques in response to endothelial aggression [1,2].…”

Section: Introductionmentioning

confidence: 99%

Coronary Artery Disease (CAD): A Case Report

Nunes,

Pereira Pieczarka,

Melato

et al. 2021

OAJGGM

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Background: Atherosclerotic disease is the result of several factors, as well as its symptoms, which are commonly associated with somatic pictures. Also, its incidence prevails in the elderly population. Case presentation:The case presents with an elderly patient referring to thoracic pain, characterized as typical angina and, also, crises that were aggravated by physical efforts. The first tests showed no significant changes and the patient was treated with pain medications and emotional condition. However, after some years the exams showed Coronary Arterial Disease, and the treatment focused on the somatization of the symptoms of the pathology with the depressive picture. However, the effectiveness of the treatment and the disappearance of the symptoms occurred only with the intervention of physical exercises in the routine and improvement of the diet. Conclusion:The conclusion of the case highlights the need for a global view of the patient and a therapy associated with physical exercise to treat Coronary Arterial Disease.

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Monocitose é um marcador de risco independente para a doença arterial coronariana

Cited by 26 publications

References 20 publications

Exploring the Causal Link Between Immune Cell Phenotypes and Asthma Through Two-Sample and Bayesian Weighted Mendelian Randomization

Exploring the Causal Link Between Immune Cell Phenotypes and Asthma Through Two-Sample and Bayesian Weighted Mendelian Randomization

Epitranscriptomics of Ischemic Heart Disease—The IHD-EPITRAN Study Design and Objectives

Coronary Artery Disease (CAD): A Case Report

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