Dosagem dos níveis de NT pro-BNP nas afecções pericárdicas e sua utilidade como método complementar de avaliação de restrição diastólica. Experiência inicial de 25 casos: 25 cases

Abstract

OBJECTIVETo determine whether NT pro-BNP levels are high in patients reporting pericardial diseases, as well as to investigate how they relate to diastolic dysfunction echocardiographic measures. METHODSTwenty-fi ve patients were split into two groups: 1) pericardial effusion (PE): 15 patients; 2) constrictive pericaditis (CP): 10 patients. A control group was made up with 30 individuals reporting no heart disease. Pericadial effusion was evaluated by bidimensional echocardiogram, with restriction evaluated by pulsed Doppler of mitral fl ow. CP diagnosis was confi rmed by MRI. NT pro-BNP levels were measured by immunoassay and detected by electrochemiluminescence. RESULTSFrom the 15 PD patients, 14 reported relevant PD, and only 1, moderate PD. Log NT pro-BNP was shown to be higher in PD (p <0.05), with log mean of 2.31 pg/ml and CP (p <0.05), with log mean of 2.67 pg/ml, when compared to control group, log mean of 1.32 pg/ ml. No difference was reported between PD and CP (p = 0.149). The NT pro-BNP log showed to be correlated to peak velocity of the E wave (r = 0.845; p = 0.001) and with E/A (r=0.717; p= 0.003). CONCLUSIONNT pro-BNP is shown to have increased in pericardial diseases, and is associated to diastolic dysfunction. It may serve as an additional method in quantifying restriction. KEY WORDSPericardial effusion, constrictive pericaditis, NT pro-BNP.