Disfunção erétil: um marcador para alterações da perfusão miocárdica?

Abstract

OBJECTIVETo study the correlation between erectile dysfunction (ED) and myocardial perfusion impairment in men with suspected or diagnosed coronary artery disease (CAD). METHODSIn this prospective study a self-administered IIEF-5 questionnaire was answered by 287 patients that underwent myocardial perfusion imaging under both resting and stress condition with technetium-99m sestamibi, through gated SPECT nuclear scintigraphy technique, before and after physical or pharmacological stress. RESULTSSome degree of erectile dysfunction (group ED+) was found in 137 (47.8%) patients and in these, age was significantly higher (60.60±9.84 vs 50.67±9.94 -p<0.001)) than in those without erectile dysfunction (group ED-). In the ED+ group, it was observed a higher prevalence of hypertension, diabetes, myocardial infarction (MI) and percutaneous coronary angioplasty (PCTA). Regardless of the age factor, ED+ patients also presented higher occurrence of myocardial perfusion impairment (necrosis and/or ischemia) and left ventricular systolic wall motion and thickening abnormalities. CONCLUSIONPatients with ED have higher estimated probability of presenting segmental myocardial perfusion and functional contraction impairment and, therefore, CAD, independent of the aging factor. The authors conclude that ED may be considered not only a marker for CAD but also a condition related to the occurrence of major coronary events such as MI and PCTA.KEY WORDS erectile dysfunction, coronary artery disease, nuclear medicine, myocardial perfusion, risk factors, atherosclerosis

Association between Coronary Artery Disease and Erectile Dysfunction in Patients of a University Hospital

“…Thus, the IIEF is a very sensitive noninvasive test to indicate the need for further investigation, since ED appears as an early symptom of cardiovascular disease 19,20 . This result corroborates evidence of an association between ED and heart disease 28 .…”

Perfusão miocárdica e reserva de fluxo fracionada por tomografia computadorizada e cintilografia em pacientes com isquemia pelo teste ergométrico

“…idade, sexo, características da dor torácica, presença de fatores de risco para DAC (HAS, DM, tabagismo, dislipidemia, sedentarismo, história familiar de DAC, e outras patologias que pudessem estar associadas à doença cardiovascular 29 (disfunção erétil 30,31 , doenças reumáticas 32 , hiperuricemia 33 , hipovitaminose D 34 ), peso (kg), altura (cm), Índice de massa corporal 29 , PA em repouso (sentado, no consultório 35,36 ). Foram calculados os escore de risco de Framingham 37 e o escore de risco global (ACC/AHA) 38 a todos os pacientes incluídos, e o escore de Diamond-Forrester 39 (aos pacientes que referiam dor torácica -típica, atípica ou dor não cardíaca).…”