Remodelação miocárdica após infarto agudo do miocárdio experimental em ratos: efeito do bloqueio do sistema renina angiotensina aldosterona

Epifanio, Hindalis Ballesteros; Zornoff, Leonardo A. M.; Matsubara, Beatriz Bojikian; Paiva, Sérgio Alberto Rupp de; Inoue, R; Matsubara, Luiz Shiguero

doi:10.1590/s0066-782x2005000100003

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…The inhibition of the renin-angiotensin-aldosterone system, induced by angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), reduces myocardial fibrosis, regardless of its hypotensive action [28]. In addition, the selective AT1 angiotensin II antagonist prevents myocyte hypertrophy and interstitial fibrosis [29]. Most patients use ARBs or ACEIs during the dialysis period.…”

Section: Discussionmentioning

confidence: 99%

Kidney transplantation is associated with reduced myocardial fibrosis. A cardiovascular magnetic resonance study with native T1 mapping

Contti

Barbosa

Maurício

et al. 2019

Journal of Cardiovascular Magnetic Resonance

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Background The measurement of native T1 through cardiovascular magnetic resonance (CMR) is a noninvasive method of assessing myocardial fibrosis without gadolinium contrast. No studies so far have evaluated native T1 after renal transplantation. The primary aim of the current study is to assess changes in the myocardium native T1 6 months after renal transplantation. Methods We prospectively evaluated 44 renal transplant patients with 3 T CMR exams: baseline at the beginning of transplantation and at 6 months after transplantation. Results The native T1 time was measured in the midventricular septum and decreased significantly from 1331 ± 52 ms at the baseline to 1298 ± 42 ms 6 months after transplantation ( p = 0.001). The patients were split into two groups through a two-step cluster algorithm: In cluster-1 ( n = 30) the left ventricular (LV) mass index and the prevalence of diabetes were lower. In cluster-2 ( n = 14) the LV mass index and diabetes prevalence were higher. Decrease in native T1 values was significant only in the patients in cluster-1 ( p = 0.001). Conclusions The native myocardial T1 time decreased significantly 6 months after renal transplant, which may be associated with the regression of the reactive fibrosis. The patients with greater baseline LV mass index and the diabetic group did not reach a significant decrease in T1. Electronic supplementary material The online version of this article (10.1186/s12968-019-0531-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Kidney transplantation is associated with reduced myocardial fibrosis. A cardiovascular magnetic resonance study with native T1 mapping

Contti

Barbosa

Maurício

et al. 2019

Journal of Cardiovascular Magnetic Resonance

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“…Earlier researchers found that many factors may influence the process of LV remodelling, such as patency of the infarctrelated artery, 23 treatment with angiotensin converting enzyme (ACE) inhibitors and/or beta-blockers, 24 and baseline BNP concentrations. 25 Treatment with renin–angiotensin–aldosterone blockers after MI was found to ameliorate the process of LV remodelling in experimental models 26 as well as in humans. 3 , 27 …”

Section: Discussionmentioning

confidence: 99%

Symptom-to-balloon time and myocardial blush grade are predictors of left ventricular remodelling after successful primary percutaneous coronary intervention

Farag¹,

Al-Daydamony²

2017

CVJA

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SummaryIntroduction:In patients with ST-segment elevation myocardial infarction (STEMI), successful primary percutaneous coronary intervention (PCI) was found to be useful in earlier restoration of TIMI flow 3. However, the incidence of left ventricular (LV) dilatation and remodelling after successful primary PCI is still high. We aimed to determine the independent predictors of LV remodelling after successful primary PCI for patients with first STEMI.Methods:We included 232 STEMI patients treated with primary PCI. Echocardiography was done on the day of PCI and after six months. LV remodelling was defined as ≥ 20% increase in the six-month left ventricular end-diastolic volume (LVEDV).Results:In patients with remodelling, symptom-to-door and symptom-to-balloon times were significantly longer (p < 0.00001 for each), initial ejection fraction (EF) was significantly lower (p = 0.044), six-month LVEDV, left ventricular end-systolic volume (LVESV) and LVEDV increase were significantly higher, and EF was significantly lower (p < 0.00001 for each). Mean myocardial blush grade (MBG) was significantly lower in patients with remodelling (p < 0.00001). There was a significant positive correlation between LVEDV increase and both symptom-to-balloon time (r = 0.603, p < 0.00001) and symptom-to-door time (r = 0.564, p < 0.00001), and a significant negative correlation between LVEDV increase and MBG (r = –0.447, p < 0.00001). Logistic regression showed that the independent predictors of LV remodelling were symptom-to-balloon time (p = 0.00068), symptom to door time (p = 0.0013) and MBG (p = 0.0057).Conclusion:Symptom-to-door time, symptom-to-balloon time and MBG were the only significant predictors of LV remodelling.

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Remodelação miocárdica após infarto agudo do miocárdio experimental em ratos: efeito do bloqueio do sistema renina angiotensina aldosterona

Cited by 2 publications

References 18 publications

Kidney transplantation is associated with reduced myocardial fibrosis. A cardiovascular magnetic resonance study with native T1 mapping

Kidney transplantation is associated with reduced myocardial fibrosis. A cardiovascular magnetic resonance study with native T1 mapping

Symptom-to-balloon time and myocardial blush grade are predictors of left ventricular remodelling after successful primary percutaneous coronary intervention

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