Estudo prospectivo e randomizado de pacientes tratados com e sem stents revestidos com carbeto de silício amorfo para a prevenção da reestenose coronariana. Avaliação ultra-sonográfica

Tanajura, Luiz Fernando; Sousa, J. Eduardo; Sousa, Amanda G.M.R.; Abizaid, Alexandre; Paula, João Eduardo Tinoco de; Albertal, Mariano; Feres, Fausto; Mattos, Luiz Alberto; Staico, Rodolfo; Pinto, Ibraim Masciarelli Francisco

doi:10.1590/s0066-782x2004001900011

Cited by 4 publications

(5 citation statements)

References 21 publications

(18 reference statements)

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“…This higher diameter may have favored Penta™ stents, because a wider vessel could accommodate intimal hyperplasia more adequately. Nevertheless, if we focus on in-stent late loss, which is considered the measurement that best reflects the real and pure biological effect of coronary stent performance 24 , we will observe that late loss was similar between the two stents, of approximately 1 mm, a value that is comparable to that observed in previous studies with diamond-like carbon 18 , silicon carbide 25 and carbon-coated 26,27 stainless steel stents.…”

Section: Discussionsupporting

confidence: 71%

Estudo comparativo randomizado do implante de Stent de aço inoxidável recoberto por carbono semelhante ao diamante versus não recoberto em pacientes com doença arterial coronariana

Meireles¹,

Abreu²,

Forte³

et al. 2007

Arq. Bras. Cardiol.

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Section: Discussionsupporting

confidence: 71%

Estudo comparativo randomizado do implante de Stent de aço inoxidável recoberto por carbono semelhante ao diamante versus não recoberto em pacientes com doença arterial coronariana

Meireles¹,

Abreu²,

Forte³

et al. 2007

Arq. Bras. Cardiol.

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“…Some studies reported endothelialization in clinical follow-ups of SiC-coated stents over a 6-month period, suggesting positive outcomes. Conversely, other studies observed increased neointimal hyperplasia within the same follow-up duration for SiC-coated stents, indicating less favorable results [60]. In a clinical trial comparing SiC-coated stents from Biotronik (Germany) with 316L NIR stents from Boston Scientific (USA), no definitive superiority was found between the two stent types in terms of major adverse coronary events during an 8 to 12-week follow-up period [56].…”

Section: Silicon-carbide (Sic)mentioning

confidence: 96%

Surface Engineering of Bioactive Coatings for Improved Stent Hemocompatibility: A Comprehensive Review

Raikar,

Priya,

Bhilegaonkar

et al. 2023

Preprint

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Cardiovascular diseases continuing to be a major contributor to illness and death on a global scale and the implementation of stents has given rise to a revolutionary transformation in the field of interventional cardiology. The thrombotic and restenosis complications associated with stent implantation pose ongoing challenges. In recent years, bioactive coatings have emerged as a promising strategy to enhance stent hemocompatibility and reduce thrombogenicity. This review article provides an overview of the surface engineering techniques employed to improve the hemocompatibility of stents and reduce thrombus formation. It explores the mechanisms underlying thrombosis and discusses the factors influencing platelet activation and fibrin formation on stent surfaces. Various bioactive coatings, including anticoagulant agents, antiplatelet agents, and surface modifications, are discussed in detail, highlighting their potential in reducing thrombogenicity. Evaluation methods for assessing hemocompatibility and thrombogenicity are also reviewed, ranging from in vitro assays to animal models. Recent advances in the field, such as nanotechnology-based coatings and bioactive coatings with controlled drug release systems, are highlighted. Surface engineering of bioactive coatings holds great promise for enhancing the long-term outcomes of stent implantation by enhancing hemocompatibility and reducing thrombogenicity. Future research directions and potential clinical applications are discussed, underscoring the need for continued advancements in this field.

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“…Thierry et al developed a HA-paclitaxel (HA-Pac) prodrug by linking paclitaxel to HA via a labile succinate ester linkage and showed that the drug could be maintained active and be released by naturally occurring hydrolysis from self-assembled multilayers over 20 hours. 134 The ability to incorporate bioactive molecules in polyelectrolyte multilayers has great potential in the field of stent coating along with drug delivery systems.…”

Section: Chitosan Based Composites and Self-assembly Coatingsmentioning

confidence: 99%

Review of stent coating strategies: Clinical insights

Sydow-Plum¹,

Tabrizian²

2008

Materials Science and Technology

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Despite advances in stent design, expansion techniques and anti-thrombotic agents to improve pharmacological control of subacute thrombosis (SAT) and to reduce to 2 the occlusive thrombosis rates, a significant risk of mortality associated with thrombotic vascular occlusion due to the adhesion of blood constituents remains a problem for patients with more complex lesions. The adhesion process is greatly governed by the surface characteristics, mainly the surface chemical composition, surface morphology, presence of charge, surface wettability and surface roughness. Surface chemical inertness (reduced interaction with chemicals and biological components) subsequently became the primary criteria which guided the development of non thrombotic stents as well as other blood-contacting materials. A number of strategies have been adopted in an effort to coat the stent with or without the use of a drug delivery system, to overcome the thrombus formation, to minimize the stent occlusion and to improve the overall hemocompatibility of the device. This paper aims at reviewing the clinical outcomes of main nonpharmaceutical stent coating procedures and their clinical outcomes. New stents which combine the anti-thrombotic coating with the drug delivery ability, such as radioactive stents, degradable stents and some new challenging trends which are mostly at research and development stage for stent surface coatings are also introduced.

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Estudo prospectivo e randomizado de pacientes tratados com e sem stents revestidos com carbeto de silício amorfo para a prevenção da reestenose coronariana. Avaliação ultra-sonográfica

Abstract: 0.999) e a revascularização do vaso-alvo (16% vs 14%; p>0.999) não diferiram. CONCLUSÃO: Os stents revestidos apresentaram resultados clínicos, angiográficos e ultra-sonográficos similares aos controles.]]>

Cited by 4 publications

References 21 publications

Estudo comparativo randomizado do implante de Stent de aço inoxidável recoberto por carbono semelhante ao diamante versus não recoberto em pacientes com doença arterial coronariana

Estudo comparativo randomizado do implante de Stent de aço inoxidável recoberto por carbono semelhante ao diamante versus não recoberto em pacientes com doença arterial coronariana

Surface Engineering of Bioactive Coatings for Improved Stent Hemocompatibility: A Comprehensive Review

Review of stent coating strategies: Clinical insights

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