Insuficiência cardíaca com função sistólica preservada

Mesquita, Evandro Tinoco; Socrates, Jaderson; Rassi, Salvador; Villacorta, Humberto; Mady, Charles

doi:10.1590/s0066-782x2004000500014

Cited by 17 publications

(9 citation statements)

References 30 publications

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“…Heart failure represents the heart incapacity of performing sufficient cardiac output to satisfy all body demands 3,20,11 either with preserved ejection fraction or not. 8,16 There are several potential mechanisms by which endothelial dysfunction may contribute to disease progression in patients with heart failure (HF).…”

Section: Resultsmentioning

confidence: 99%

Detailing Peripheral Arterial Tonometry in Heart Failure. An Endothelial Function Evaluation

Tavares¹,

Bocchi²,

Guimarães³

2017

International Journal of Cardiovascular Sciences

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Section: Resultsmentioning

confidence: 99%

Detailing Peripheral Arterial Tonometry in Heart Failure. An Endothelial Function Evaluation

Tavares¹,

Bocchi²,

Guimarães³

2017

International Journal of Cardiovascular Sciences

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“…It is also a good predictor of adverse events in several clinic situations, such as diastolic dysfunction (31,32), independently of the presence of cardiovascular disease, left ventricle systolic dysfunction and ventricular hypertrophy (32). Alteration of LA/ AO ratio provoked by LA enlargement in IG rabbits indicates cardiac diastolic damage of ventricular complacency or relaxing, which may alter the EF (33). Due to the resistance against ventricular distention, the augmented LA contracts more (Frank-Starling law), provoking increase of the atrial flow velocity as previously observed.…”

Section: Time (T) Groupsmentioning

confidence: 99%

Cardiac evaluation after experimental intoxication by Amorimia rigida (Malpighiaceae) extracts in rabbits

Borboleta¹,

Ef²,

Oliveira³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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Clinical and laboratory changes were evaluated in rabbits after intoxication by Amorimia rigida, a plant that causes sudden death. Nine New Zealand male rabbits, averaging 3.54 kg, were categorized into three groups (n = 3) and received, for eight consecutive days, the equivalent of 30 g/kg dry matter of A. rigida water-soluble (SG) and water-insoluble (IG) extracts via nasoesophageal route. The control group received water. There were no alterations in creatine kinase enzyme (CK), CK myocardial fraction (CKMB) or troponine I (cTnI). None of the animals had clinical or electrocardiographic (conventional and Holter) alterations. There were progressive decreases in the left ventricular ejection fraction and systolic fractional shortening. Doppler echocardiography alterations suggested a systolic dysfunction in the SG and IG groups and diastolic dysfunction in IG group. It was concluded that the soluble and insoluble extracts of A. rigida cause deficit of cardiac function.Key words: toxic plant, Amorimia rigida, cardiac muscle profile, electrocardiography, echocardiography, rabbit. Original PaPer The Journal of Venomous Animals and Toxins including Tropical Diseases ISSN 1678-9199 | 2012 | volume 18 | issue 3 | pages 295-305 INTRODUCTIONThe genus Amorimia (Malpighiaceae) contains one of the 10 most important toxic plants in South America (1), best known of which is Amorimia rigida (Mascagnia rigida), well distributed in Minas Gerais state (Brazil), mainly in the northern and northeastern regions, where it is popularly known as "salsa-rosa" or "suma-roxa". It belongs to a group that causes acute intoxication that may provoke death preceded or not by a short period of clinical signs (2).After A. rigida intake, animals may show apathy, anorexia, rigid walking, prolonged recumbence, muscle tremors and death, among other clinical signs. Significant alterations have not been found at necropsy of animals intoxicated by A. rigida. Multifocal infiltrate of lymphocytes in the myocardium associated with edema and congestion of myocytes was found in the histological exams (3).Studies are necessary to elucidate which physiopathological mechanisms are involved in A. rigida intoxication that leads to sudden death. In spite of the existence of some reports of mortality in the absence of cardiac lesions, it is suggested that the main action of this plant in the heart may be due to its phytochemical characteristics that might affect cardiac function within a period insufficient to produce alterations detectable by optical microscopy (4).To the best of our knowledge, no previous study has concurrently evaluated continuous electrocardiography (Holter), Doppler echocardiography and the cardiac muscle biochemical profile in animals after the intake of A. rigida. Thus, the present work aimed to ascertain the influence of this plant on the cardiac system using the rabbit as the experimental model. MATERIALS AND METHODS Animal AssaysNine six-month-old white New Zealand male rabbits weighing an average of 3.54 kg were used. Firstl...

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“…Therefore, the complete understanding of the systolic dysfunction of the muscular pump in the presence of a preserved performance of the hemodynamic pump, that is, normal EF, would undoubtedly be a key pathway to the understanding of the initial stage of the HF syndrome, which we call HFNEF 1,4 . Although patients with HFNEF have a better prognosis than those with HFREF, they present significant morbidity and mortality, and the prognosis after hospitalization for HF is poor 7,8,10 , with a mortality rate of approximately 20% in one year 9 . Although strategies based on recent evidences for the treatment of HF have favorably modified the outcomes for patients with HFREF, studies have shown increased prevalence rates of HFNEF without change in mortality over the past 20 years 8 .…”

Section: Key Elements Of the Pathophysiology Of Cardiac Dysfunctionmentioning

confidence: 99%

Insuficiência cardíaca com fração de ejeção normal: novos critérios diagnósticos e avanços fisiopatológicos

Mesquita¹,

Jorge²

2009

Arq. Bras. Cardiol.

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Heart failure (HF) is a highly prevalent complex cardiovascular syndrome, and its clinical presentation is usually associated with ventricular dilatation, decreased contractility and reduced left ventricular ejection fraction (EF). However, in the past two decades studies have demonstrated that many patients with signs and symptoms of HF have normal EF (higher than 50%). The great challenge for doctors lies in the identification of patients presenting heart failure with normal ejection fraction (HFNEF) and this challenge seems to be mainly related to the high complexity of the syndrome and to the lack of a standardized method to confirm or exclude the diagnosis that could be used in the daily clinical practice. Unlike in heart failure with reduced ejection fraction (HFREF) in which one single parameter - EF lower than 50%, is sufficient to confirm the diagnosis of the syndrome, in HFNEF different diastolic indexes have been used to characterize the presence or absence of diastolic dysfunction (DD). The purpose of this review is to show new concepts related to the diastolic function that will help understand the cardiovascular pathophysiology of HFNEF, and to discuss the new guideline of the European Society of Cardiology for the diagnosis and exclusion of HFNEF based on cardiac function indices obtained using tissue Doppler imaging (TDI) and natriuretic peptide determination.

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Insuficiência cardíaca com função sistólica preservada

Cited by 17 publications

References 30 publications

Detailing Peripheral Arterial Tonometry in Heart Failure. An Endothelial Function Evaluation

Detailing Peripheral Arterial Tonometry in Heart Failure. An Endothelial Function Evaluation

Cardiac evaluation after experimental intoxication by Amorimia rigida (Malpighiaceae) extracts in rabbits

Insuficiência cardíaca com fração de ejeção normal: novos critérios diagnósticos e avanços fisiopatológicos

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