Intrauterine ductus arteriosus constriction: analysis of a historic cohort of 20 cases

Reversal of fetal ductal constriction after maternal restriction of polyphenol-rich foods: an open clinical trial

“…This finding is consistent with the conceptual hypothesis that maternal consumption of substances with anti-inflammatory effects in late pregnancy may have a constrictive action upon the fetal ductus, as a result of prostaglandin biosynthesis inhibition. [1][2][3]14,[16][17][18] There are many evidences supporting this view, such as the demonstration that normal fetuses exposed to a maternal daily diet with higher content of polyphenol substances (above the 75th percentile) have higher ductal velocities and RV/LV ratios than fetuses exposed to lower amounts of PRF (below the 25th percentile). 15,16 A cause and effect relationship between maternal ingestion of polyphenol-rich beverages and fetal DC in late pregnancy has been experimentally shown in an animal model using fetal lambs.…”

“…[1][2][3][4][5] Constriction of fetal ductus arteriosus (DA) is a risk factor for pulmonary hypertension in the newborn period, with its known severe consequences. [6][7][8][9][10][11] For several years, many reports have been discussing the high prevalence of DC in the absence of a known trigger effect.…”

“…11 It has been discussed that other extrinsic factors, in addition to NSAID, could be involved in the genesis of this important clinical situation. 1,12,13 We and others have already suggested that maternal ingestion of polyphenol-rich foods (PRF) in late pregnancy, such as herbal teas, grape juice, dark chocolate and others, could be associated to fetal DC. [14][15][16][17][18] Experimental studies in fetal lambs have supported this hypothesis, showing a cause and effect relationship of maternal consumption of green tea and other polyphenol-rich substances with constriction of fetal DA in the animal model.…”

Premature constriction of the fetal ductus arteriosus following the maternal consumption of camomile herbal tea

“…differ between these two groups, with more unfavorable outcome in the idiopathic ductus closure group despite Doppler indices of a milder degree of constriction at diagnosis 3 . This could be explained by removal of the underlying cause, thereby limiting or permitting reversal of cardiac compromise.…”

“…In a cohort of 20 cases of intrauterine ductus arteriosus constriction, NSAID usage as a precipitant was identified in only 30% 3 …”