A Participação do Tecido Adiposo Visceral na Gênese da Hipertensão e Doença Cardiovascular Aterogênica: Um Conceito Emergente

Avaliação por imagem da área de gordura visceral e suas correlações com alterações metabólicas

“…In the present study, the mean VAT area values were higher in the elderly group and a mean > 130 cm 2 was observed only in male elderly individuals. There is scientific evidence that, in both sexes, an increase in the amount of visceral adipose tissue occurs with age and that regardless of the body mass, the accumulation of visceral fat is more predominant in men than in women 27 , although abdominal obesity is common in post-menopausal women 28 .…”

“…Androgenic obesity, represented by the excess deposition of visceral abdominal adipose tissue, is associated with a higher risk of metabolic and hemodynamic disorders and favors the occurrence of events, such as arterial hypertension, atherogenic cardiovascular disease, diabetes mellitus, gout and coronary disease [1][2][3] , increasing the need for medication use and interfering with the quality of life.…”

“…The literature has pointed out several physiopathological mechanisms to explain such association, although they are yet to be elucidated 2,[4][5][6] . A large number of endocrine alterations is more frequent in the presence of visceral obesity, when compared to the peripheral obesity, due to the differentiation in the metabolic and endocrine activity, more active in the visceral adipose tissue (VAT) 5,7,8 .…”

“…Moreover, the VAT presents lower insulin sensitivity and contribution to lipolysis, by showing a faster insulin-receptor dissociation 7,8 . According to several authors 2,9,10 , the metabolic alterations, which include dyslipidemia, insulin resistance and morbidities such as hypertension and cardiovascular disease, are independent from the degree of obesity and are of equal magnitude for both sexes, with the visceral tissue being the probable mediator of this association.…”

Prevalência de pré-hipertensão e de hipertensão arterial e avaliação de fatores associados em crianças e adolescentes de escolas públicas de Salvador, Bahia, Brasil

“…Dentre as alterações, destacam-se as hemodinâmicas sistêmicas e renais, resistência à insulina com hiperinsulinemia compensatória, ativação do sistema nervoso simpático e do sistema renina-angiotensina, além de efeitos da leptina plasmática 53,54,55 . O uso de análise fatorial com o método de extração dos componentes principais no QFA tem sido utilizado em diversos estudos para determinar os padrões alimentares 56,57,58,59 .…”