Prevalence of Chagas' Disease in Mulungu do Morro Northeastern Brazil

Aras, Roque; Veiga, Marielza; Gomes, Irênio; Mota, Gildo; Rodrigues, Bernardo; Rabelo, Rosângela; Guzmán-Bracho, Carmen; Melo, Aílton

doi:10.1590/s0066-782x2002000500001

Cited by 16 publications

(11 citation statements)

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“…Even though there are estimates for the reduction of the prevalence in Latin America, Chagas disease is one of the main problems of public health and a leading cause of heart failure in endemic areas 1,2,5,14 . In spite of this fact, there is a shortage of medical literature dealing with the topics of epidemiology and relevance of new therapies for heart failure secondary to Chagas disease.…”

Section: Discussionmentioning

confidence: 99%

Aspectos clínicos e terapêuticos da insuficiência cardíaca por doença de Chagas

Braga¹,

Reis²,

Aras³

et al. 2006

Arq. Bras. Cardiol.

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OBJECTIVEDescribe the clinical and therapeutic characteristics of patients with heart failure (HF) secondary to chronic chagasic cardiomyopathy and evaluate if these characteristics are different from those found in other etiologies. METHODS RESULTSThree hundred and fi fty six patients diagnosed with HF were included in the study. Chagasic cardiomyopathy was the most common etiology (48% of the cases). Other etiologies included hypertensive cardiomyopathy in 19% of the patients, idiopathic dilated in 11% and ischemic in 9%. Patients with HF secondary to chagasic cardiomyopathy were more frequently from non-white ethnic groups (88 vs. 75%; p = 0.002), had a family history of Chagas disease (57 vs. 21%; p = 0.001), had the disease for a longer length of time (71 vs. 56 months; p = 0.034), had lower levels of education (4.4 ± 4.1 vs. 5.7 ± 4.2 years of study; p = 0.004), had a lower heart rate (69 ± 12 vs. 73 ± 13; p = 0.03) and a lower systolic blood pressure (121 ± 25 vs. 129 ± 28 mmHg; p = 0.006). There was also a higher incidence of the use of amiodarone (22 vs. 13%; p = 0.036) and artifi cial pacemakers (15 vs. 1%; p = 0.001). There was a lower usage of beta-blockers (39 vs. 59%; p = 0.001). CONCLUSIONIn this sample of HF outpatients, in a state with a high prevalence of Chagas disease, chagasic cardiomyopathy was the most common etiology and they presented some unique clinical and therapeutic characteristics in comparison to other heart failure patients. KEY WORDSChagasic cardiomyopathy, heart failure, epidemiology.

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Section: Discussionmentioning

confidence: 99%

Aspectos clínicos e terapêuticos da insuficiência cardíaca por doença de Chagas

Braga¹,

Reis²,

Aras³

et al. 2006

Arq. Bras. Cardiol.

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“…These data are higher than overall percentages in both the state (5.4%) and the country (4.2%). 27 In the sample population studied, there was a high prevalence of seropositivity in school-aged children and young adults, a finding which indicates the occurrence of vector transmission. 28 As a consequence of intensive campaigns to eliminate domestic triatomines, Brazil has successfully reduced epidemic vector transmission of T. cruzi.…”

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confidence: 90%

Triatominae Survey (Hemiptera: Reduviidae: Triatominae) in the South-Central Region of the State of Bahia, Brazil Between 2008 and 2013

Mendonça¹,

Oliveira²,

Rimoldi³

et al. 2015

The American Journal of Tropical Medicine and Hygiene

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Abstract. Triatomine surveillance in rural areas, artificial ecotypes, and natural ecotopes of the cities of Caturama, Ibipitanga, Macaú bas, and Seabra in the south-central region of the Brazilian state of Bahia was carried out between 2008 and 2013. Natural infection by Trypanosoma cruzi was evaluated in the specimens collected to monitor vectors of Chagas disease. A total of 1,357 specimens were collected, and four species were identified: Triatoma sordida (83%), Triatoma lenti (16.4%), Triatoma pseudomaculata (0.5%), and Panstrongylus geniculatus (0.1%). Triatoma sordida was found in four cities, only 0.7% in intradomiciliary environments. Triatoma lenti was found only in Macaú bas; 8.5% were found in intradomiciliary environments, 88.3% in peridomiciliary environments, and 3.1% in sylvatic environments. Natural infection by T. cruzi was 0.5% for T. sordida and 3.1% T. lenti. All of these cases were found in peridomiciliary environments of Macaú bas. As the results show, triatomines were found in intradomiciliary environments in three cities that were surveyed in the south-central region of the state of Bahia. Thus, an epidemiologic survey should be performed to avoid the risk of transmission to the population.Chagas disease, also known as American trypanosomiasis, is caused by the protozoan parasite Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae). It is most frequently transmitted by the infected feces of blood-sucking triatomine bugs (Hemiptera: Reduviidae: Triatominae).

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“…The disease is endemic throughout Central and South America where about 17 million people are estimated to be infected and 100 million are at risk of infection [1]. In Brazil, the overall prevalence of Chagas disease is 4.2% and in the northeast region the infection rate can reach more than 5.0% [1]–[3]. In endemic areas, the primary infection usually occurs in children aged 15 years and under.…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes of Thirteen Patients with Acute Chagas Disease Acquired through Oral Transmission from Two Urban Outbreaks in Northeastern Brazil

et al. 2010

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BackgroundOutbreaks of orally transmitted Trypanosoma cruzi continue to be reported in Brazil and are associated with a high mortality rate, mainly due to myocarditis.MethodsThis study is a detailed report on the disease progression of acute Chagas disease in 13 patients who were infected during two micro-outbreaks in two northeastern Brazilian towns. Clinical outcomes as well as EKG and ECHO results are described, both before and after benznidazole treatment.ResultsFever and dyspnea were the most frequent symptoms observed. Other clinical findings included myalgia, periorbital edema, headache and systolic murmur. Two patients died of cardiac failure before receiving benznidazole treatment. EKG and ECHO findings frequently showed a disturbance in ventricular repolarization and pericardial effusion. Ventricular dysfunction (ejection fraction <55%) was present in 27.3% of patients. After treatment, EKG readings normalized in 91.7% of patients. Ventricular repolarization abnormalities persisted in 50% of the patients, while sinus bradycardia was observed in 18%. The systolic ejection fraction normalized in two out of three patients with initially depressed ventricular function, while pericardial effusion disappeared.ConclusionsMyocarditis is frequently found and potentially severe in patients with acute Chagas disease. Benznidazole treatment may improve clinical symptoms, as well as EKG and ECHO findings.

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Prevalence of Chagas' Disease in Mulungu do Morro Northeastern Brazil

Cited by 16 publications

References 1 publication

Aspectos clínicos e terapêuticos da insuficiência cardíaca por doença de Chagas

Aspectos clínicos e terapêuticos da insuficiência cardíaca por doença de Chagas

Triatominae Survey (Hemiptera: Reduviidae: Triatominae) in the South-Central Region of the State of Bahia, Brazil Between 2008 and 2013

Clinical Outcomes of Thirteen Patients with Acute Chagas Disease Acquired through Oral Transmission from Two Urban Outbreaks in Northeastern Brazil

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