Cytokines and troponin-I in cardiac dysfunction after coronary artery grafting with cardiopulmonary bypass

Savaris, Neverton; Polanczyk, Carísi Anne; Clausell, Nadine Oliveira

doi:10.1590/s0066-782x2001000800002

Cited by 15 publications

(12 citation statements)

References 18 publications

(22 reference statements)

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“…Aortic clamping and extra-corporeal circulation probably constitute the most important causes of metabolic changes in patients undergoing intervention (Savaris et al 2001;Berkan and Sagban 2002). This is confirmed in our study; together with TnT, it is the myoglobin variable that best detects the changes, in relation to the type of surgery.…”

Section: Discussionsupporting

confidence: 84%

Plasma Troponins as Markers of Myocardial Damage during Cardiac Surgery with Extracorporeal Circulation

Stefano¹,

Casquero²,

Bustamante

et al. 2007

Tohoku J. Exp. Med.

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All types of cardiac surgery involve considerable injury to the myocardium. However, it is difficult to differentiate, in the immediate postoperative state, between ischemic alterations associated with the cardiac surgery itself and the pathological alterations of a peri-operative myocardial infarction. The diagnosis of damaged myocardium, classically performed with the enzymatic markers creatine kinase (CK) and its muscle fraction (CK-MB), has become more precise with the option of measuring cardiac troponins T and I. We measured these markers in 58 patients undergoing elective cardiac surgery with extra-corporeal circulation (ECC). The patients included 37 cases undergoing valve surgery, 14 for coronary revascularization, 6 for mixed procedures, and 1 for closure of an inter-atrial communication. The markers were measured in plasma at baseline (at anesthesia initiation), 5 min post-ECC commencement, following aorta de-clamping, during the surgical closure, and 6, 18 and 42 hrs after surgery. All the markers were increased significantly relative to the baseline values. Troponin I, CK and CK-MB values peaked between 6 and 18 hrs after surgery, troponin T between 18 and 42 hrs, and myoglobin at the surgical closure. The values of all markers were higher in patients undergoing coronary surgery compared to those in patients undergoing valve surgery. In the evaluation of myocardial damage after surgery, the measurement of classical markers such as CK and myoglobin remain valid, but other markers such as troponins provide significant additional diagnostic benefit and, thus, need to be included in the routine biochemical measurements for monitoring myocardial damage associated with the surgical procedure.Peri-operative myocardial damage; injury markers; troponin; creatine kinase; myoglobin

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Section: Discussionsupporting

confidence: 84%

Plasma Troponins as Markers of Myocardial Damage during Cardiac Surgery with Extracorporeal Circulation

Stefano¹,

Casquero²,

Bustamante

et al. 2007

Tohoku J. Exp. Med.

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“…Nevertheless, the practical logistic difficulty of transferring all patients from the intensive care unit in the first few postoperative days after heart surgery, when they are frequently in severe conditions, with pleural and mediastinal drains and sometimes with other apparatuses, such as catheters to monitor pulmonary arterial pressure and systemic arterial pressure, pacemakers and intra-aortic balloons, to a nuclear medicine laboratory to perform myocardial scintigraphy with pyrophosphate technetium, is unfeasible. Even though recently there have been some publications describing the use of troponin in MR [4][5][6], a consensus has not been reached yet that defines a cutoff point in the diagnosis of perioperative AMI.…”

Section: Commentsmentioning

confidence: 99%

Fatores preditores de infarto do miocárdio no período perioperatório de cirurgia de revascularização miocárdica

Jaeger¹,

Kalil²,

Guaragna³

et al. 2005

Rev Bras Cir Cardiovasc

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“…These are caused by a systemic response, due to the non-physiological nature of cardiopulmonary bypass (CABG), which induces a systemic inflammatory reaction mediated by autoimmune substances, such as interleukins and their complements 7,8 . Moreover, the use of CABG with an arrested heart may result in myocardial dysfunction and, in some patients, hibernating myocardium, hemorrhagic diathesis, neurological impairment, tissue edema, and renal failure 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Qualidade de vida após revascularização cirúrgica do miocárdio com e sem circulação extracorpórea

Nogueira¹,

Hueb²,

Takiuti³

et al. 2008

Arq. Bras. Cardiol.

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Cytokines and troponin-I in cardiac dysfunction after coronary artery grafting with cardiopulmonary bypass

Abstract: Objective -The association between cytokines and troponin-I with cardiac function after cardiac surgery with cardiopulmonary bypass remains a topic of continued investigation. Methods -

Cited by 15 publications

References 18 publications

Plasma Troponins as Markers of Myocardial Damage during Cardiac Surgery with Extracorporeal Circulation

Plasma Troponins as Markers of Myocardial Damage during Cardiac Surgery with Extracorporeal Circulation

Fatores preditores de infarto do miocárdio no período perioperatório de cirurgia de revascularização miocárdica

Qualidade de vida após revascularização cirúrgica do miocárdio com e sem circulação extracorpórea

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