Endothelial dysfunction and coronary artery disease

Caramori, Paulo; Zago, Alcides José

doi:10.1590/s0066-782x2000000800009

Cited by 22 publications

(16 citation statements)

References 114 publications

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“…Briefly, patients were accommodated in the supine position at the examination room, with temperature between 22 and 25 8C. Two pneumatic cuffs, 3connected to Hokanson plethysmograph system (Bellevue, DC, USA), were placed, one around the left arm and another around the left wrist to isolate forearm circulation, as well as an elastic stretch mercury sensor, positioned at the largest circumference of the left forearm. Blood pressure was measured in the contralateral arm and heart rate continuously monitored by electrodes placed on the chest connected to the plethysmograph.…”

Section: Data Collectionmentioning

confidence: 99%

“…Data from experimental and clinical studies have shown a relationship between estrogen decay and endothelial dysfunction (2), the first and most precocious marker of atherosclerotic process, (3). Testosterone levels show less pronounced descent (2-4 times), compared with estrogens (16 times) (4) because postmenopausal ovaries continue to produce testosterone.…”

Section: Introductionmentioning

confidence: 99%

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Low testosterone levels are associated with endothelial dysfunction in oophorectomized early postmenopausal women

Rech

Clapauch

Souza

2016

European Journal of Endocrinology

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Background: The actual consequences of low testosterone levels in women remain uncertain. Objective: To assess endogenous testosterone influence on body composition, vascular and metabolic function in recent postmenopausal women. Design: We studied 81 postmenopausal women under transdermal estradiol (E 2 ) replacement therapy, 36 with bilateral oophorectomy (group O), and 45 controls (group C) through venous occlusion plethysmography, bioimpedance, DEXA, biochemical, hormonal, and inflammatory profile. Results: Total testosterone level (TT) in group O was 11.0 (4.0-17.75) vs 23.0 (10.0-42.5) ng/dl in group C (PZ0.001). Forearm blood flow, in ml/min/100 ml tissue, was lower in group O compared to group C at baseline (1.57 (1.05-2.47) vs 2.19 (1.59-2.66) PZ0.036), following reactive hyperemia response (endothelium-dependent flow mediated dilatation, 3.44 (2.38-4.35) vs 4.3 (3.09-5.52), PZ0.031) and following nitroglycerin (endothelium-independent dilation, 1.39 (0.99-1.7) vs 1.76 (1.15-2.0), PZ0.025), with a positive correlation between TT and all parameters except for the reactive hyperemia response (rZ0.233-0.312, PZ0.036-0.004). The sVCAM1 levels were negatively correlated with TT (rZ-0.320, PZ0.005). E 2 and other hormone levels, biochemical parameters and body composition did not differ between groups. Multiple linear regressions showed that the levels of TT, compared with other confounding variables, may explain the variation observed on endothelial parameters, with low explanatory power. Conclusion: The absence of ovarian testosterone production in recent postmenopausal oophorectomized women was associated with deleterious effects on endothelial function.

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Section: Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low testosterone levels are associated with endothelial dysfunction in oophorectomized early postmenopausal women

Rech

Clapauch

Souza

2016

European Journal of Endocrinology

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“…16 • Inhibition of cell proliferation of vascular smooth muscles, preventing the migration of smooth muscle cells through direct mechanisms, such as synthesis of nitric oxide, which inhibits cell proliferation, and/or indirect ones (platelet action). 17,18 • Active participation in immune response through the release of factors leading to active contraction, control of plasma extravasation, as well as increase in the expression of integrins, molecules of adhesion and secretion of cytokines, allowing the migration of monocytes, lymphocytes, and neutrophils and greater local phagocytic activity.…”

Section: The Endotheliummentioning

confidence: 99%

Menopause, Estrogens, and Endothelial Dysfunction: Current Concepts

Maturana

Irigoyen

Spritzer

2007

Clinics

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Maturana MA, Irigoyen MC, Spritzer PM. Menopause, estrogens, and endothelial dysfunction: current concepts. Clinics. 2007;62(1):77-86. Menopause is defined as the permanent cessation of menses. Cardiovascular disease is the leading cause of death among postmenopausal women in developed countries. The disparity between the incidence of cardiovascular disease among women in pre-and postmenopause has been ascribed to the actions of endogenous estrogen on the cardiovascular system and, particularly, on the vascular endothelium. The endothelium plays an important role in cardiovascular homeostasis, either through the vascular tonus and its regulation, or through coagulation and the inflammatory response. Endothelial dysfunction is implicated in the genesis of atherosclerosis and other chronic disorders, such as diabetes mellitus and hypertension. The pharmacological use of estrogen exerts influence on the circulating levels of markers of vascular tonus, and inflammation, as well as prothrombotic, and fibrinolytic markers, but the impact of these changes on the atherosclerotic disease is still uncertain.

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“…The resultant effect of this impairment may be partly due to alterations in the nitric oxide (NO) pathway, notably a reduction in endotheliumderived NO bioavailability (2)(3). Chronically reduced NO bioavailability could play a mechanistic role in the progression of cardiovascular disease (CVD) (2).…”

Section: Introductionmentioning

confidence: 99%

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

Wong

Howe

Buckley

et al. 2011

Nutrition, Metabolism and Cardiovascular Diseases

253

218

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243Text 2129 Number of references 31 Number of figures 3Number of tables 1 and on FMD (P<0.01), which increased from 4.1 ± 0.8% (placebo) to 7.7 ± 1.5% after 270mg resveratrol. FMD was also linearly related to log10 plasma resveratrol concentration (P<0.01).(3) Conclusion-Acute resveratrol consumption increased plasma resveratrol concentrations and FMD in a dose-related manner. This effect may contribute to the purported cardiovascular health benefits of grapes and red wine.4

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Endothelial dysfunction and coronary artery disease

Cited by 22 publications

References 114 publications

Low testosterone levels are associated with endothelial dysfunction in oophorectomized early postmenopausal women

Low testosterone levels are associated with endothelial dysfunction in oophorectomized early postmenopausal women

Menopause, Estrogens, and Endothelial Dysfunction: Current Concepts

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure

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