2000
DOI: 10.1590/s0066-782x2000000700010
|View full text |Cite
|
Sign up to set email alerts
|

Adaptation to exercise following cardiac transplantation

Abstract: Cardiac transplantation has been the treatment of choice for patients with terminal cardiac insufficiency, increasing survival time by more than 80% in the first year 1 and by more than 50% over ten years 2 . Following cardiac transplantation, the quality of life improves considerably, and many transplanted patients return to work becoming reintegrated into the community 3 . During regular activity, transplanted subjects have shown physical conditioning similar to that of healthy individuals 4-7 . Starling's a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
5
0

Year Published

2020
2020
2022
2022

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(5 citation statements)
references
References 61 publications
0
5
0
Order By: Relevance
“…223,224 Among other factors, this can be explained by: 1) in the immediate post-transplant period, the allograft is devoid of sympathetic and parasympathetic innervation (autonomic denervation), causing an increase in resting HR, attenuating its natural elevation in response to exercise, and impairing recovery after exertion 224,225 ; 2 ) patients often exhibit skeletal muscle dysfunction (sometimes to the point of cachexia), in which immunosuppressive therapy and pre-transplant HF play prominent roles 226 ; and 3) impairment of vascular and diastolic function. 227 During the acute phase of exercise, the increase in cardiac output of HTx recipients depends fundamentally on the Frank-Starling mechanism, i.e., on increase in venous return, inotropy, chronotropy, and reduction in afterload. 228,229 In addition, there is an increase in the concentrations of circulating catecholamines, 227 which decrease slowly after the end of exercise, explaining the slow recovery of HR in these patients.…”
Section: Heart Transplantationmentioning
confidence: 99%
See 1 more Smart Citation
“…223,224 Among other factors, this can be explained by: 1) in the immediate post-transplant period, the allograft is devoid of sympathetic and parasympathetic innervation (autonomic denervation), causing an increase in resting HR, attenuating its natural elevation in response to exercise, and impairing recovery after exertion 224,225 ; 2 ) patients often exhibit skeletal muscle dysfunction (sometimes to the point of cachexia), in which immunosuppressive therapy and pre-transplant HF play prominent roles 226 ; and 3) impairment of vascular and diastolic function. 227 During the acute phase of exercise, the increase in cardiac output of HTx recipients depends fundamentally on the Frank-Starling mechanism, i.e., on increase in venous return, inotropy, chronotropy, and reduction in afterload. 228,229 In addition, there is an increase in the concentrations of circulating catecholamines, 227 which decrease slowly after the end of exercise, explaining the slow recovery of HR in these patients.…”
Section: Heart Transplantationmentioning
confidence: 99%
“…227 During the acute phase of exercise, the increase in cardiac output of HTx recipients depends fundamentally on the Frank-Starling mechanism, i.e., on increase in venous return, inotropy, chronotropy, and reduction in afterload. 228,229 In addition, there is an increase in the concentrations of circulating catecholamines, 227 which decrease slowly after the end of exercise, explaining the slow recovery of HR in these patients. 230 Immunosuppression may predispose HTx recipients to a higher risk of other complications, 231 and these patients may develop HTN, diabetes mellitus, and CAD.…”
Section: Heart Transplantationmentioning
confidence: 99%
“…In the general population, exercise should be the preferred stressor when stress echocardiography is performed. Nonetheless, physical exercise might not represent an adequate cardiovascular stressor for the denervated allograft, mostly because of impaired chronotropic response [10,[35][36][37]. Thus, in this population of patients, stress echocardiography with pharmacological agents seems to be more favorable when this technique is indicated.…”
Section: Stress Echocardiographymentioning
confidence: 99%
“…Although the recipients improve both in functional capacity and quality of life (QoL), these are still not equivalent to the same levels of healthy individuals. 3 The long waiting period, caused by the lack of organ donors, often makes patients unprepared for the transplant physically and mentally. In addition to the classic cardiovascular risk factors, we still have the patient's lack of adherence to the programs, knowledge deficits about the rules of conduct after transplantation, non-acceptance of the new organ, fear of rejection, lack of a physical exercise routine, strategies for coping and occupational health issues and social rights.…”
mentioning
confidence: 99%