Doppler echocardiographic evaluation of HIV-positive patients in different stages of the disease

Werneck, Guilherme Lobosco; Mesquita, Evandro Tinoco; Fo, Luiz José Martins Romêo; Ribeiro, Mário Luiz

doi:10.1590/s0066-782x1999000800004

Cited by 13 publications

(14 citation statements)

References 52 publications

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“…[12] In this study 5.3% patients has Pulmonary Hypertension, it is comparable with Singh et al (2012) in which incidence is 11.4%. In our study only one patient had vegetation on ECHO.…”

Section: Section: Medicinesupporting

confidence: 89%

“…In our study 5.3% patients has dilated cardiomyopathy that is comparable with other studies like study by Olusegun-Joseph et al (2012) in 2012 dilated cardiomyopathy incidence was 5%, study by singh et al in 2012 incidence was 8.5% and study did by Jain et al (2014) incidence was 17.6%. [10,12] The incidence of DCMP rise with fall in CD4 counts. Systolic dysfunction was detected in 6 patients ((4%) in our study.…”

Section: Cd4 Countmentioning

confidence: 99%

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A Study of Cardiac Manifestations of HIV/AIDS

Sachdeva¹,

Kaur²,

Khurana³

et al. 2017

Ann. Int. Med. Den.Res.

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Background: Cardiovascular involvement is common in HIV reactive patients, although are clinically quiescent. Echocardiography in HIV reactive patients is important tool in recognizing these cardiac abnormalities. Methods: The study was conducted in 150 HIV reactive patients attending antiretroviral therapy centre and wards of the hospital. Echocardiography was done using GE Vivid 3 Milwaukee using 2.5 MHz variable frequency transducer and CD4+ count was measured by FACS (Flourescent Activator Cell Sorter). Patients with age <15 years, congenital heart disease, preexisting valvular heart disease, hypertension and diabetes mellitus were excluded from study. Patients were divided into three groups according to CD4+ counts: group 1 with CD4+ count <200, group 2 with 201-350 and group 3 with > 350 CD4+ cells. Data so collected was statistically analysed and correlation with CD4+ count was studied. Results: Out of 150 patients, echocardiographic involvement was shown in 62 (41.3 %) patients. Most common echocardiographic abnormality was diastolic dysfunction in 26 % (most of the patients had grade 1 diastolic dysfunction), followed by pericardial effusion in 8.6 %. 6.7% had systolic dysfunction and 5.3% had features of dilated cardiomyopathy. The mean CD4+ count in patients with grade 1 diastolic dysfunction and systolic dysfunction was significantly lower than in patients without diastolic dysfunction and systolic dysfunction (166.9 versus 210.65). Same was true with patients having pericardial effusion and dilated cardiomyopathy. Pulmonary hypertension was seen in 5.8 % of patients. Conclusion: The prevalence of echocardiographic manifestations in HIV reactive patients was quiet high. High index of clinical suspicion of cardiac involvement and its recognition in HIV patients at all stages help in early diagnosis and treatment which in turn will decrease morbidity and mortality.

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“…[12] In this study 5.3% patients has Pulmonary Hypertension, it is comparable with Singh et al (2012) in which incidence is 11.4%. In our study only one patient had vegetation on ECHO.…”

Section: Section: Medicinesupporting

confidence: 89%

Section: Cd4 Countmentioning

confidence: 99%

A Study of Cardiac Manifestations of HIV/AIDS

Sachdeva¹,

Kaur²,

Khurana³

et al. 2017

Ann. Int. Med. Den.Res.

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“…The dysfunction was more frequent with disease progression, paralleling the reports by other workers 9,10,28,37. Systolic dysfunction is said to be an important cause of morbidity and mortality in AIDS patients 38. It is also posited that symptomatic heart failure will occur in approximately 6% of these patients, especially at the end stage of the disease 26,35,39.…”

Section: Discussionsupporting

confidence: 71%

“…Systolic dysfunction, which is a frequently documented finding in echocardiography of HIV-infected patients,9,10,28,37,38 was noted in about a third of our cases, signifying reduced myocardial contractility. The dysfunction was more frequent with disease progression, paralleling the reports by other workers 9,10,28,37.…”

Section: Discussionmentioning

confidence: 53%

Echocardiographic patterns in treatment-naïve HIV-positive patients in Lagos, south-west Nigeria : cardiovascular topic - online article

Olusegun-Joseph

Ajuluchukwu

Okany

et al. 2012

CVJA

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IntroductionCardiovascular abnormalities are common in HIV-infected patients, although often clinically quiescent. This study sought to identify by echocardiography early abnormalities in treatment-naïve patients.MethodsOne hundred patients and 50 controls with no known traditional risk factors for cardiovascular disease were recruited for the study. The cases and controls were matched for age, gender and body mass index. Both groups had clinical and echocardiographic evaluation for cardiac abnormalities, and CD4 count was measured in all patients.ResultsThe cases comprised 57 females (57.0%) and 43 males (43.0%), while the controls were 28 females (56.0%) and 22 males (44.0%) (χ2 = 0.01; p = 0.913). The mean age of the cases was 33.2 ± 7.7, while that of the controls was 31.7 ± 9.7 (t = 1.02; p = 0.31). Echocardiographic abnormalities were significantly more common in the cases than the controls (78 vs 16%; p = 0.000), including systolic dysfunction (30 vs 8%; p = 0.024) and diastolic dysfunction (32 vs 8%; p = 0.002). Other abnormalities noted in the cases were pericardial effusion in 47% (χ2 = 32.10; p = 0.000) and dilated cardiomyopathy in 5% (five); none of the controls had either complication. One patient each had aortic root dilatation, mitral valve prolapse and isolated right heart dilatation and dysfunction.ConclusionCardiac abnormalities are more common in HIV-infected people than in normal controls. A careful initial and periodic cardiac evaluation to detect early involvement of the heart in the HIV disease is recommended.

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“…Im Gegensatz zum Nachweis HIV-assoziierter Manifestationen mittels MRT existiert für die Echokardiographie eine Reihe von Studien [6,11,12,18,20,23,31]. Eine der Studien, die die Entwicklung kardialer Manifestationen untersuchte, stellt in diesem Zusammenhang die Arbeit von Blanchard et al dar [7].…”

Section: Introductionunclassified

Diagnostik kardialer Manifestationen bei HIV-positiven Patienten mittels nichtinvasiver Bildgebung

Kondratieva

Breuckmann

Naßenstein

et al. 2005

Herz

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HIV infection is frequently associated with cardiovascular involvement. Particularly new treatment concepts, including the highly active antiretroviral therapy, are suspected to increase the rate of cardiac and cardiovascular complications in this patient population. Hence, noninvasive techniques such as transthoracic echocardiography and magnetic resonance imaging will become more important in the routine screening as well as in specific diagnostics of cardiovascular involvement of HIV infection. The present article describes the options of these noninvasive techniques for the detection of HIV-associated cardiac manifestations.

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Doppler echocardiographic evaluation of HIV-positive patients in different stages of the disease

Cited by 13 publications

References 52 publications

A Study of Cardiac Manifestations of HIV/AIDS

A Study of Cardiac Manifestations of HIV/AIDS

Echocardiographic patterns in treatment-naïve HIV-positive patients in Lagos, south-west Nigeria : cardiovascular topic - online article

Diagnostik kardialer Manifestationen bei HIV-positiven Patienten mittels nichtinvasiver Bildgebung

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