Beta-adrenergic pathway in healthy and hypertrophied hearts

Barros, Rodrigo Garcia; Okoshi, Marina Politi; Cicogna, Antônio Carlos

doi:10.1590/s0066-782x1999000500012

Cited by 7 publications

(7 citation statements)

References 67 publications

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“…Além disso, no espaço intracitoplasmático, o receptor beta-adrenérgico pode ser consumido, fenômeno este chamado de sequestro, o que acarreta diminuição do número de receptores celulares (BENOVIC et al, 1988). Esta variação no número de receptores por unidade de sarcolema é denominada down-regulation (BARROS et al, 1999). Portanto, é possível que esses fenômenos possam ter ocorrido neste estudo.…”

Section: Resultsunclassified

Alimentação de suínos em terminação com dietas contendo ractopamina e extratos cítricos: desempenho e características de carcaça

et al. 2010

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Section: Resultsunclassified

Alimentação de suínos em terminação com dietas contendo ractopamina e extratos cítricos: desempenho e características de carcaça

et al. 2010

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“…β, β-adrenergic receptor; γ/β, γ and β subunits of the G protein; G α , α subunit of the G protein; GTP, guanosine triphosphate; AC, adenyl cyclase; ATP, adenosine triphosphate; cAMP, cyclic adenosine monophosphate; PKA, cAMP-dependent protein kinase A; E, enzyme; and EPO 4 , phosphorylated enzyme (Modified from Barros et al 1999).…”

Section: β-Adrenergic Receptor Signaling Pathwaymentioning

confidence: 99%

“…Both processes, uncoupling and down-regulation, contribute to a reduction in total βAR in the plasma membrane (Mills 2002b). subunit of the G protein; γ/β, γ and β subunits of the G protein; GTP, guanosine triphosphate; cAMP, cyclic adenosine monophosphate; PKA, cAMP-dependent protein kinase A; βARK1, β-adrenergic receptor kinase 1; P, phosphorylation; and β-Arr, β-arrestin (Modified from Barros et al 1999). …”

Section: β-Adrenergic Receptor Signaling Pathwaymentioning

confidence: 99%

Ractopamine as a metabolic modifier feed additive for finishing pigs: a review

Almeida

Nuñez

Miyada

2012

Braz. arch. biol. technol.

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The β-adrenergic agonist ractopamine is increasingly used in the swine industry due to higher consumer demand for leaner pork products. Redirecting nutrients to favor leanness rather than fat deposition, ractopamine improves growth and carcass traits of finishing pigs. However, the impact of this agonist on pork quality is not clearly defined. Understanding the biological effects of dietary ractopamine dose, treatment period, lysine levels, and the lysine to metabolizable energy ratio will help pork producers achieve improvements in animal performance, carcass leanness, and economic efficiency in swine production systems.

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“…The beta-adrenergic (βA) pathway is composed of βA receptors (βAR) coupled to G proteins (G s and G i ), adenylate cyclase (AC) and cyclic adenosine monophosphate (cAMP) [ 21 , 22 ]. The human heart contains all three βAR subtypes, β 1 AR, β 2 AR and β 3 AR [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Cardiac Dysfunction Induced by Obesity Is Not Related to β-Adrenergic System Impairment at the Receptor-Signalling Pathway

et al. 2015

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Obesity has been shown to impair myocardial performance. Some factors have been suggested as responsible for possible cardiac abnormalities in models of obesity, among them beta-adrenergic (βA) system, an important mechanism of regulation of myocardial contraction and relaxation. The objective of present study was to evaluate the involvement of βA system components in myocardial dysfunction induced by obesity. Thirty-day-old male Wistar rats were distributed in control (C, n = 25) and obese (Ob, n = 25) groups. The C group was fed a standard diet and Ob group was fed four unsaturated high-fat diets for 15 weeks. Cardiac function was evaluated by isolated papillary muscle preparation and βA system evaluated by using cumulative concentrations of isoproterenol and Western blot. After 15 weeks, the Ob rats developed higher adiposity index than C rats and several comorbidities; however, were not associated with changes in systolic blood pressure. Obesity caused structural changes and the myocardial responsiveness to post-rest contraction stimulus and increased extracellular calcium (Ca2+) was compromised. There were no changes in cardiac function between groups after βA stimulation. The obesity was not accompanied by changes in protein expression of G protein subunit alpha (Gsα) and βA receptors (β1AR and β2AR). In conclusion, the myocardial dysfunction caused by unsaturated high-fat diet-induced obesity, after 15 weeks, is not related to βAR system impairment at the receptor-signalling pathway.

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Beta-adrenergic pathway in healthy and hypertrophied hearts

Cited by 7 publications

References 67 publications

Alimentação de suínos em terminação com dietas contendo ractopamina e extratos cítricos: desempenho e características de carcaça

Alimentação de suínos em terminação com dietas contendo ractopamina e extratos cítricos: desempenho e características de carcaça

Ractopamine as a metabolic modifier feed additive for finishing pigs: a review

Cardiac Dysfunction Induced by Obesity Is Not Related to β-Adrenergic System Impairment at the Receptor-Signalling Pathway

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