Aortic stenosis. Gender influence on left ventricular geometry and function in patients under 70 years of age

Rocha, Antônio Sérgio Cordeiro da; Pereira, M. A. Vellasco; Rocha, Nazareth de Novaes; Soares, R; Grandelle, Celso Garcia; Silva, Paulo Roberto Dutra da

doi:10.1590/s0066-782x1999000400007

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…For instance, it has been noted that men have greater degrees of coronary artery calcification than women [13]. Additionally, there are gender differences in adaptation of the left ventricle to aortic stenosis [14,15] and patterns of hypertrophy [16,17] differ between the genders. In the case of calcific aortic stenosis, it has been postulated that women have greater degrees of valvular fibrosis and less intense calcification of the valve as compared to men [7].…”

Section: Discussionmentioning

confidence: 99%

Aortic stenosis calcium scoring in a racially mixed sample

Brito

Goykhman

et al. 2020

Monaldi Arch Chest Dis

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Aortic stenosis (AS) is common and increasing in prevalence as the population ages. Using computed tomography (CT) to quantify aortic valve calcification (AVC) it has been reported that men have greater degrees of calcification than women among subjects with severe AS. These data, however, were derived in largely Caucasian populations and have not been verified in non-Caucasian subjects. This retrospective study identified 137 patients with severe AS who underwent valve replacement and had CT scans within 6 months prior to surgery. AVC scores were compared between men and women, both in the entire sample and in racial subgroups. 52% of subjects were male and 62.8% were non-Caucasian. Mean AVC score for the entire cohort was 3062.08±2097.87 with a range of 428-13,089. Gender differences in aortic valve calcification were found to be statistically significant with an average AVC score of 3646±2422 in men and 2433±1453 in women (p=0.001). On multivariate analysis, gender remained significantly associated with AVC score both in the entire sample (p=0.014) and in the non-Caucasian subgroup (p=0.008). Mean AVA was significantly greater in males than females but this difference disappeared when AVA was indexed to BSA (p=0.719). AVA was not different between racial groups (p=0.369). In this research we observed that among subjects with severe AS men have higher AVC scores than women regardless of racial background. This is consistent with previous studies in predominantly Caucasian populations.

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Section: Discussionmentioning

confidence: 99%

Aortic stenosis calcium scoring in a racially mixed sample

Brito

Goykhman

et al. 2020

Monaldi Arch Chest Dis

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Men are from mars, women are from venus: Factors responsible for gender differences in outcomes after surgical and trans-catheter aortic valve replacement

Goel

Kumar

Garg

2021

Trends in Cardiovascular Medicine

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Pathophysiology of Aortic Valve Stenosis: Is It Both Fibrocalcific and Sex Specific?

et al. 2017

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Our understanding of the fundamental biology and identification of efficacious therapeutic targets in aortic valve stenosis has lagged far behind the fields of atherosclerosis and heart failure. In this review, we highlight the most clinically relevant problems facing men and women with fibrocalcific aortic valve stenosis, discuss the fundamental biology underlying valve calcification and fibrosis, and identify key molecular points of intersection with sex hormone signaling.

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Aortic stenosis. Gender influence on left ventricular geometry and function in patients under 70 years of age

Cited by 4 publications

References 14 publications

Aortic stenosis calcium scoring in a racially mixed sample

Aortic stenosis calcium scoring in a racially mixed sample

Men are from mars, women are from venus: Factors responsible for gender differences in outcomes after surgical and trans-catheter aortic valve replacement

Pathophysiology of Aortic Valve Stenosis: Is It Both Fibrocalcific and Sex Specific?

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